SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zu7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3zu7 DESIGNED ANKYRIN
REPEAT PROTEIN
(synthetic
construct) 		4 / 8 LEU B  86
TRP B  81
ASP B  77
ASP B  79
 None
 0.90A 3n2oC-3zu7B:
undetectable
3n2oD-3zu7B:
undetectable		 3n2oC-3zu7B:
14.24
3n2oD-3zu7B:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 3zu7 DESIGNED ANKYRIN
REPEAT PROTEIN
(synthetic
construct) 		5 / 11 ILE B  62
LEU B  51
HIS B  69
LEU B  67
ALA B  71
 None
 1.06A 4p65E-3zu7B:
undetectable
4p65F-3zu7B:
undetectable
4p65J-3zu7B:
undetectable
4p65L-3zu7B:
undetectable		 4p65E-3zu7B:
5.99
4p65F-3zu7B:
13.51
4p65J-3zu7B:
13.51
4p65L-3zu7B:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 3zu7 DESIGNED ANKYRIN
REPEAT PROTEIN
(synthetic
construct) 		5 / 12 VAL B  30
LEU B  18
LEU B  51
ILE B  62
ALA B  71
 None
 1.02A 4p65B-3zu7B:
undetectable
4p65D-3zu7B:
undetectable
4p65I-3zu7B:
undetectable
4p65J-3zu7B:
undetectable		 4p65B-3zu7B:
13.51
4p65D-3zu7B:
13.51
4p65I-3zu7B:
5.99
4p65J-3zu7B:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3zu7 DESIGNED ANKYRIN
REPEAT PROTEIN
(synthetic
construct) 		6 / 11 ASP B  89
ILE B 128
GLY B  91
LEU B  84
LEU B  99
VAL B  96
 None
 1.44A 5twjD-3zu7B:
undetectable		 5twjD-3zu7B:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 3zu7 DESIGNED ANKYRIN
REPEAT PROTEIN
(synthetic
construct) 		4 / 4 ILE B  62
LEU B  51
HIS B  69
ALA B  71
 None
 0.99A 6ck2C-3zu7B:
undetectable
6ck2D-3zu7B:
undetectable		 6ck2C-3zu7B:
5.99
6ck2D-3zu7B:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3zu7 DESIGNED ANKYRIN
REPEAT PROTEIN
(synthetic
construct) 		5 / 10 LEU B 133
VAL B 129
VAL B 139
ILE B 152
LEU B 161
 None
 1.12A 6h1lA-3zu7B:
undetectable		 6h1lA-3zu7B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3zu7 DESIGNED ANKYRIN
REPEAT PROTEIN
(synthetic
construct) 		4 / 7 HIS B  85
THR B  82
ARG B 123
ASP B  89
 None
 1.36A 6mn4E-3zu7B:
undetectable		 6mn4E-3zu7B:
21.37