SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zuk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 131
GLY A 155
TRP A 289
HIS A 179
 None
 0.78A 1dbbH-3zukA:
undetectable
1dbbL-3zukA:
undetectable		 1dbbH-3zukA:
13.99
1dbbL-3zukA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 5 GLY A 589
LEU A 590
THR A 591
ARG A 595
 None
 1.07A 1ekjF-3zukA:
undetectable
1ekjG-3zukA:
undetectable		 1ekjF-3zukA:
13.93
1ekjG-3zukA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		3 / 3 GLN A 168
ILE A 156
HIS A 213
 None
 0.64A 1fm9A-3zukA:
undetectable		 1fm9A-3zukA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 286
VAL A 203
TRP A 289
 None
 1.06A 1gmkC-3zukA:
undetectable
1gmkD-3zukA:
undetectable		 1gmkC-3zukA:
2.54
1gmkD-3zukA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		3 / 3 GLN A 168
ILE A 156
HIS A 213
 None
 0.63A 1k74A-3zukA:
undetectable		 1k74A-3zukA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 6 TRP A 604
ARG A 628
GLY A 563
ASP A 564
 None
RDF  A1665 (-2.6A)
None
None
 1.32A 1kf6M-3zukA:
undetectable
1kf6N-3zukA:
undetectable		 1kf6M-3zukA:
22.24
1kf6N-3zukA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 4 ASP A 564
HIS A 493
ARG A 628
GLU A 560
 None
ZN  A1664 ( 3.4A)
RDF  A1665 (-2.6A)
ZN  A1664 ( 2.3A)
 0.97A 1lqtA-3zukA:
undetectable		 1lqtA-3zukA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 480
ALA A 574
LEU A 572
LEU A 364
ALA A 489
 None
PEG  A1681 (-3.7A)
None
None
None
 1.13A 1sn5B-3zukA:
undetectable
1sn5D-3zukA:
undetectable		 1sn5B-3zukA:
12.15
1sn5D-3zukA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 364
ALA A 489
GLU A 480
ALA A 574
LEU A 572
 None
None
None
PEG  A1681 (-3.7A)
None
 1.14A 1sn5B-3zukA:
undetectable
1sn5D-3zukA:
undetectable		 1sn5B-3zukA:
12.15
1sn5D-3zukA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.83A 1v7zA-3zukA:
undetectable		 1v7zA-3zukA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.84A 1v7zB-3zukA:
undetectable		 1v7zB-3zukA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.84A 1v7zC-3zukA:
undetectable		 1v7zC-3zukA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.86A 1v7zD-3zukA:
undetectable		 1v7zD-3zukA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.87A 1v7zE-3zukA:
undetectable		 1v7zE-3zukA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.85A 1v7zF-3zukA:
undetectable		 1v7zF-3zukA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 453
HIS A 493
GLU A 494
HIS A 497
GLU A 560
 RDF  A1665 (-4.3A)
ZN  A1664 ( 3.4A)
RDF  A1665 (-2.5A)
ZN  A1664 (-3.1A)
ZN  A1664 ( 2.3A)
 0.37A 2c6nA-3zukA:
4.4		 2c6nA-3zukA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 538
TRP A 604
TYR A 535
HIS A 493
 None
None
None
ZN  A1664 ( 3.4A)
 1.33A 2ha2A-3zukA:
undetectable		 2ha2A-3zukA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 538
TRP A 604
TYR A 535
HIS A 493
 None
None
None
ZN  A1664 ( 3.4A)
 1.33A 2ha2B-3zukA:
undetectable		 2ha2B-3zukA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 8 GLY A 131
GLY A 132
TRP A 275
PHE A 241
PHE A 271
 None
 1.16A 2ha4A-3zukA:
undetectable		 2ha4A-3zukA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 SER A  86
LEU A  83
ASP A 412
ASP A 414
 PEG  A1669 (-4.6A)
None
None
None
 0.96A 2j2pA-3zukA:
undetectable
2j2pB-3zukA:
undetectable		 2j2pA-3zukA:
15.47
2j2pB-3zukA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 6 SER A  86
LEU A  83
ASP A 412
ASP A 414
 PEG  A1669 (-4.6A)
None
None
None
 0.96A 2j2pE-3zukA:
undetectable
2j2pF-3zukA:
undetectable		 2j2pE-3zukA:
15.47
2j2pF-3zukA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 564
ILE A 661
ILE A 562
GLY A 496
ILE A 495
 None
 0.98A 2o4nA-3zukA:
undetectable		 2o4nA-3zukA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 498
GLY A 503
ALA A 222
GLY A 559
ASP A 501
 None
PGE  A1684 ( 3.9A)
PGE  A1684 ( 4.5A)
None
None
 0.96A 2pkkA-3zukA:
undetectable		 2pkkA-3zukA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XUD_A_DMEA1544_1
(ACETYLCHOLINESTERASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 6 TYR A 538
TRP A 604
TYR A 535
HIS A 493
 None
None
None
ZN  A1664 ( 3.4A)
 1.34A 2xudA-3zukA:
0.0		 2xudA-3zukA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.83A 3a6jA-3zukA:
undetectable		 3a6jA-3zukA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.80A 3a6jB-3zukA:
undetectable		 3a6jB-3zukA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.80A 3a6jC-3zukA:
undetectable		 3a6jC-3zukA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.85A 3a6jE-3zukA:
undetectable		 3a6jE-3zukA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.80A 3a6jF-3zukA:
undetectable		 3a6jF-3zukA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 567
ILE A 570
ILE A 495
ASP A 564
 None
 0.93A 3a7eA-3zukA:
undetectable		 3a7eA-3zukA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 210
ILE A 156
LEU A 158
LEU A 173
VAL A 172
 None
 1.24A 3adsB-3zukA:
undetectable		 3adsB-3zukA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 12 GLN A 602
ALA A 481
PHE A 643
GLY A 486
LEU A 568
 PEG  A1667 ( 4.6A)
None
None
None
None
 1.31A 3aodC-3zukA:
undetectable		 3aodC-3zukA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 410
LEU A 409
GLN A 421
TYR A 417
 None
 0.88A 3cldB-3zukA:
undetectable		 3cldB-3zukA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		3 / 3 ASN A 630
MET A 593
PHE A 639
 None
 1.06A 3g4lD-3zukA:
undetectable		 3g4lD-3zukA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 176
GLU A 206
TYR A 311
LEU A 315
 None
 1.04A 3rqwC-3zukA:
undetectable
3rqwD-3zukA:
undetectable		 3rqwC-3zukA:
18.00
3rqwD-3zukA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 206
TYR A 311
LEU A 315
TYR A 176
 None
 1.08A 3rqwF-3zukA:
undetectable
3rqwJ-3zukA:
undetectable		 3rqwF-3zukA:
18.00
3rqwJ-3zukA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 7 PRO A 100
GLY A  97
ALA A  96
ARG A  95
 PEG  A1669 (-4.6A)
None
PEG  A1669 ( 4.0A)
None
 0.88A 3ur0B-3zukA:
0.6		 3ur0B-3zukA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 600
VAL A  28
TRP A 604
 None
 1.23A 3zq8A-3zukA:
undetectable
3zq8B-3zukA:
undetectable		 3zq8A-3zukA:
2.54
3zq8B-3zukA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		6 / 12 GLY A 130
GLY A 131
GLY A 132
SER A 154
PHE A 241
PHE A 271
 ACT  A1692 ( 4.0A)
None
None
ACT  A1692 ( 4.9A)
None
None
 1.48A 4ey6A-3zukA:
undetectable		 4ey6A-3zukA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 303
MET A 183
ASP A 103
 None
 0.80A 4j7xB-3zukA:
undetectable		 4j7xB-3zukA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 9 VAL A 596
ALA A 482
TYR A 484
GLY A 567
GLY A 486
 None
 1.16A 4mm5A-3zukA:
undetectable		 4mm5A-3zukA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 596
ALA A 482
TYR A 484
GLY A 567
GLY A 486
 None
 1.22A 4mm8A-3zukA:
undetectable		 4mm8A-3zukA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 596
ALA A 482
TYR A 484
GLY A 567
GLY A 486
 None
 1.26A 4mm9A-3zukA:
undetectable		 4mm9A-3zukA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 9 VAL A 596
ALA A 482
TYR A 484
GLY A 567
GLY A 486
 None
 1.18A 4mmbA-3zukA:
undetectable		 4mmbA-3zukA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 596
ALA A 482
TYR A 484
GLY A 567
GLY A 486
 None
 1.13A 4mmdA-3zukA:
undetectable		 4mmdA-3zukA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 596
ALA A 482
TYR A 484
GLY A 567
GLY A 486
 None
 1.14A 4mmdB-3zukA:
undetectable		 4mmdB-3zukA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 9 VAL A 596
ALA A 482
TYR A 484
GLY A 567
GLY A 486
 None
 1.15A 4mmeA-3zukA:
1.2		 4mmeA-3zukA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 9 VAL A 596
ALA A 482
TYR A 484
GLY A 567
GLY A 486
 None
 1.14A 4mmeB-3zukA:
2.2		 4mmeB-3zukA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 9 VAL A 596
ALA A 482
TYR A 484
GLY A 567
GLY A 486
 None
 1.19A 4mmfA-3zukA:
undetectable		 4mmfA-3zukA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 9 VAL A 596
ALA A 482
TYR A 484
GLY A 567
GLY A 486
 None
 1.16A 4mmfB-3zukA:
undetectable		 4mmfB-3zukA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 331
ASP A 415
VAL A 426
ALA A 425
 None
None
None
PEG  A1674 ( 4.3A)
 1.13A 4nkvC-3zukA:
undetectable		 4nkvC-3zukA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 531
HIS A 497
HIS A 493
GLU A 560
 None
ZN  A1664 (-3.1A)
ZN  A1664 ( 3.4A)
ZN  A1664 ( 2.3A)
 1.13A 4pahA-3zukA:
undetectable		 4pahA-3zukA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		3 / 3 THR A 557
ASN A 630
PHE A  25
 None
 0.70A 4pd9A-3zukA:
0.6		 4pd9A-3zukA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 6 TYR A 163
GLU A 612
THR A 316
LEU A 315
 None
SO4  A1694 ( 4.4A)
None
None
 1.49A 4qztA-3zukA:
undetectable		 4qztA-3zukA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 367
VAL A 596
TYR A 484
GLY A 567
GLY A 486
 None
 1.11A 4xp4A-3zukA:
undetectable		 4xp4A-3zukA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 11 GLN A 502
PHE A 524
TRP A 516
GLY A 498
GLY A 496
 None
ACT  A1690 ( 4.9A)
ACT  A1690 (-3.7A)
None
None
 1.45A 4zvmA-3zukA:
undetectable
4zvmB-3zukA:
2.5		 4zvmA-3zukA:
15.44
4zvmB-3zukA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 570
GLY A 492
LEU A  24
ASP A 564
 None
 0.82A 5hieB-3zukA:
undetectable		 5hieB-3zukA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 500
GLY A 563
ASP A 501
ASN A 561
 PGE  A1684 ( 3.8A)
None
None
None
 0.96A 5nnwD-3zukA:
undetectable		 5nnwD-3zukA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 500
GLY A 563
ASP A 501
ASN A 561
 PGE  A1684 ( 3.8A)
None
None
None
 0.97A 5no9D-3zukA:
undetectable		 5no9D-3zukA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 568
GLY A 566
GLY A 563
VAL A 490
ALA A 571
 None
None
None
RDF  A1665 ( 4.3A)
None
 1.07A 5o96C-3zukA:
undetectable
5o96D-3zukA:
undetectable		 5o96C-3zukA:
19.17
5o96D-3zukA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 568
GLY A 566
GLY A 563
VAL A 490
ALA A 571
 None
None
None
RDF  A1665 ( 4.3A)
None
 1.05A 5o96E-3zukA:
undetectable
5o96F-3zukA:
undetectable		 5o96E-3zukA:
19.17
5o96F-3zukA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 568
GLY A 566
GLY A 563
VAL A 490
ALA A 571
 None
None
None
RDF  A1665 ( 4.3A)
None
 1.08A 5o96G-3zukA:
undetectable
5o96H-3zukA:
undetectable		 5o96G-3zukA:
19.17
5o96H-3zukA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 357
ILE A 487
ALA A 489
ILE A 570
ALA A 367
 None
 1.08A 5vceA-3zukA:
undetectable		 5vceA-3zukA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 492
ILE A 487
GLN A 602
TYR A 484
 None
None
PEG  A1667 ( 4.6A)
None
 1.14A 5vlmC-3zukA:
2.1		 5vlmC-3zukA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 500
GLY A 496
GLU A 494
ASN A 452
HIS A 493
 PGE  A1684 ( 3.8A)
None
RDF  A1665 (-2.5A)
RDF  A1665 (-3.2A)
ZN  A1664 ( 3.4A)
 1.32A 5x7pB-3zukA:
0.7		 5x7pB-3zukA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		3 / 3 GLN A 168
ILE A 156
HIS A 213
 None
 0.69A 5z12B-3zukA:
undetectable		 5z12B-3zukA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 ASP A 501
ILE A 562
ARG A 220
ASN A 635
 None
 1.09A 6hisA-3zukA:
undetectable
6hisB-3zukA:
undetectable		 6hisA-3zukA:
8.24
6hisB-3zukA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 ASP A 501
ILE A 562
ARG A 220
ASN A 635
 None
 1.09A 6hisB-3zukA:
undetectable
6hisC-3zukA:
undetectable		 6hisB-3zukA:
8.24
6hisC-3zukA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 ASP A 501
ILE A 562
ARG A 220
ASN A 635
 None
 1.09A 6hisC-3zukA:
undetectable
6hisD-3zukA:
undetectable		 6hisC-3zukA:
8.24
6hisD-3zukA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 ASP A 501
ILE A 562
ARG A 220
ASN A 635
 None
 1.07A 6hisD-3zukA:
undetectable
6hisE-3zukA:
undetectable		 6hisD-3zukA:
8.24
6hisE-3zukA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 635
ASP A 501
ILE A 562
ARG A 220
 None
 1.10A 6hisA-3zukA:
undetectable
6hisE-3zukA:
undetectable		 6hisA-3zukA:
8.24
6hisE-3zukA:
8.24