SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zus'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 11 ILE A  38
ILE A  98
PHE A  95
ILE A 111
ILE A  42
 None
 1.02A 1dyrA-3zusA:
undetectable		 1dyrA-3zusA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		6 / 12 THR A 220
HIS A 223
GLU A 224
HIS A 227
GLU A 262
TYR A 366
 None
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
ZN  A1916 (-3.3A)
ZN  A1916 (-2.0A)
None
 0.82A 1j36A-3zusA:
3.9		 1j36A-3zusA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		6 / 12 THR A 220
HIS A 223
GLU A 224
HIS A 227
GLU A 262
TYR A 366
 None
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
ZN  A1916 (-3.3A)
ZN  A1916 (-2.0A)
None
 0.82A 1j36B-3zusA:
2.1		 1j36B-3zusA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 11 HIS A 223
GLU A 224
HIS A 227
GLU A 262
TYR A 366
 ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
ZN  A1916 (-3.3A)
ZN  A1916 (-2.0A)
None
 0.80A 1j37A-3zusA:
2.1		 1j37A-3zusA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 11 HIS A 223
GLU A 224
HIS A 227
GLU A 262
TYR A 366
 ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
ZN  A1916 (-3.3A)
ZN  A1916 (-2.0A)
None
 0.80A 1j37B-3zusA:
2.0		 1j37B-3zusA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 6 TYR A  77
VAL A 379
ILE A 378
LEU A 416
 None
 1.11A 1j96A-3zusA:
undetectable		 1j96A-3zusA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 12 HIS A 223
GLU A 224
HIS A 227
GLU A 262
TYR A 366
 ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
ZN  A1916 (-3.3A)
ZN  A1916 (-2.0A)
None
 0.91A 1o86A-3zusA:
3.3		 1o86A-3zusA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_Q_TRPQ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 10 GLY A 229
HIS A 230
HIS A 227
ILE A 111
THR A 265
 None
None
ZN  A1916 (-3.3A)
None
None
 1.17A 1utdQ-3zusA:
undetectable
1utdR-3zusA:
undetectable		 1utdQ-3zusA:
6.44
1utdR-3zusA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 8 GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
 0.88A 1v7zA-3zusA:
undetectable		 1v7zA-3zusA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 8 GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
 0.88A 1v7zB-3zusA:
undetectable		 1v7zB-3zusA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 8 GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
 0.88A 1v7zC-3zusA:
undetectable		 1v7zC-3zusA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 8 GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
 0.90A 1v7zD-3zusA:
undetectable		 1v7zD-3zusA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 8 GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
 0.90A 1v7zE-3zusA:
undetectable		 1v7zE-3zusA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 8 GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
 0.89A 1v7zF-3zusA:
undetectable		 1v7zF-3zusA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		3 / 3 LYS A 780
ASP A 270
ASN A 368
 None
 1.02A 2bm9A-3zusA:
undetectable		 2bm9A-3zusA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 12 HIS A 223
GLU A 224
HIS A 227
GLU A 262
TYR A 366
 ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
ZN  A1916 (-3.3A)
ZN  A1916 (-2.0A)
None
 0.83A 2c6nA-3zusA:
2.2		 2c6nA-3zusA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 12 HIS A 223
GLU A 224
HIS A 227
GLU A 262
TYR A 366
 ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
ZN  A1916 (-3.3A)
ZN  A1916 (-2.0A)
None
 0.86A 2c6nB-3zusA:
undetectable		 2c6nB-3zusA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		6 / 11 GLY A 704
ALA A 705
ASP A 701
GLY A 688
ILE A 687
ILE A 713
 None
 1.40A 2fxeB-3zusA:
undetectable		 2fxeB-3zusA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		3 / 3 ASP A 519
ASN A 520
THR A 765
 None
 0.72A 2q63B-3zusA:
undetectable		 2q63B-3zusA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 6 GLU A 197
MET A 831
LYS A 781
ILE A 827
 None
 1.26A 2w98B-3zusA:
undetectable		 2w98B-3zusA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 11 HIS A 223
GLU A 224
HIS A 227
GLU A 262
TYR A 366
 ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
ZN  A1916 (-3.3A)
ZN  A1916 (-2.0A)
None
 0.87A 2x8zA-3zusA:
3.6		 2x8zA-3zusA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 12 HIS A 223
GLU A 224
HIS A 227
GLU A 262
TYR A 366
 ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
ZN  A1916 (-3.3A)
ZN  A1916 (-2.0A)
None
 0.89A 2x91A-3zusA:
2.2		 2x91A-3zusA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		3 / 3 PHE A 425
ASN A 509
PHE A 587
 None
 1.09A 2zbuD-3zusA:
undetectable		 2zbuD-3zusA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 8 GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
 0.90A 3a6jA-3zusA:
undetectable		 3a6jA-3zusA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 7 GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
 0.88A 3a6jB-3zusA:
undetectable		 3a6jB-3zusA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 8 GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
 0.88A 3a6jC-3zusA:
undetectable		 3a6jC-3zusA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 8 GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
 0.91A 3a6jE-3zusA:
undetectable		 3a6jE-3zusA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 8 GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
 0.88A 3a6jF-3zusA:
undetectable		 3a6jF-3zusA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		6 / 12 GLY A 704
ALA A 705
ASP A 701
GLY A 688
ILE A 687
ILE A 713
 None
 1.39A 3ekqA-3zusA:
undetectable		 3ekqA-3zusA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		3 / 3 THR A 535
LYS A 905
GLU A 529
 None
 1.00A 3ijdB-3zusA:
undetectable		 3ijdB-3zusA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 10 VAL A 202
ASP A 203
SER A 199
ARG A 911
LEU A 838
 None
 1.44A 3j6gB-3zusA:
undetectable		 3j6gB-3zusA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 10 VAL A 202
ASP A 203
SER A 199
ARG A 911
LEU A 838
 None
 1.44A 3j6gD-3zusA:
undetectable		 3j6gD-3zusA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 10 VAL A 202
ASP A 203
SER A 199
ARG A 911
LEU A 838
 None
 1.44A 3j6gF-3zusA:
undetectable		 3j6gF-3zusA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 10 VAL A 202
ASP A 203
SER A 199
ARG A 911
LEU A 838
 None
 1.45A 3j6gH-3zusA:
undetectable		 3j6gH-3zusA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 10 VAL A 202
ASP A 203
SER A 199
ARG A 911
LEU A 838
 None
 1.44A 3j6gJ-3zusA:
undetectable		 3j6gJ-3zusA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 10 VAL A 202
ASP A 203
SER A 199
ARG A 911
LEU A 838
 None
 1.45A 3j6gL-3zusA:
undetectable		 3j6gL-3zusA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 10 VAL A 202
ASP A 203
SER A 199
ARG A 911
LEU A 838
 None
 1.44A 3j6gN-3zusA:
undetectable		 3j6gN-3zusA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 10 VAL A 202
ASP A 203
SER A 199
ARG A 911
LEU A 838
 None
 1.44A 3j6gP-3zusA:
undetectable		 3j6gP-3zusA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 10 VAL A 202
ASP A 203
SER A 199
ARG A 911
LEU A 838
 None
 1.44A 3j6gR-3zusA:
undetectable		 3j6gR-3zusA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		3 / 3 HIS A 223
GLU A 224
HIS A 227
 ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
ZN  A1916 (-3.3A)
 0.19A 3kecB-3zusA:
undetectable		 3kecB-3zusA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 7 LEU A 208
LEU A 361
ASN A 405
THR A 193
 None
 0.78A 3lm8B-3zusA:
undetectable
3lm8D-3zusA:
undetectable		 3lm8B-3zusA:
13.58
3lm8D-3zusA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		3 / 3 GLU A 538
GLU A 279
ASN A 280
 None
 0.89A 3lp9B-3zusA:
undetectable
3lp9D-3zusA:
undetectable		 3lp9B-3zusA:
14.29
3lp9D-3zusA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		3 / 3 GLU A 758
GLU A 279
ASN A 280
 None
 0.84A 3lp9B-3zusA:
undetectable
3lp9D-3zusA:
undetectable		 3lp9B-3zusA:
14.29
3lp9D-3zusA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		3 / 3 HIS A 227
HIS A 230
ILE A 226
 ZN  A1916 (-3.3A)
None
None
 0.86A 3u52A-3zusA:
undetectable
3u52C-3zusA:
undetectable		 3u52A-3zusA:
21.29
3u52C-3zusA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 6 ASP A 270
GLY A 268
ASP A 352
THR A 350
 None
 1.13A 3vqrA-3zusA:
undetectable		 3vqrA-3zusA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 5 ASP A 270
GLY A 268
ASP A 352
THR A 350
 None
 1.16A 3vqrB-3zusA:
undetectable		 3vqrB-3zusA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 11 HIS A 223
GLU A 224
HIS A 227
GLU A 262
TYR A 366
 ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
ZN  A1916 (-3.3A)
ZN  A1916 (-2.0A)
None
 0.83A 4c2pA-3zusA:
2.1		 4c2pA-3zusA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 12 ILE A 154
LEU A 225
LEU A 151
ILE A 153
TYR A  87
 None
 1.08A 4m2xE-3zusA:
undetectable		 4m2xE-3zusA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 12 LEU A 103
LEU A 108
LEU A 225
ILE A 226
PHE A 354
 None
 0.99A 4odrA-3zusA:
undetectable
4odrB-3zusA:
undetectable		 4odrA-3zusA:
7.99
4odrB-3zusA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 11 LEU A 103
LEU A 108
LEU A 225
ILE A 226
PHE A 354
 None
 1.07A 4odrA-3zusA:
undetectable
4odrB-3zusA:
undetectable		 4odrA-3zusA:
7.99
4odrB-3zusA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		3 / 3 THR A 101
ASN A 391
PHE A 390
 None
 0.46A 4pd9A-3zusA:
2.4		 4pd9A-3zusA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		3 / 3 ALA A  35
TRP A  43
VAL A  44
 None
 0.19A 4w9nC-3zusA:
undetectable		 4w9nC-3zusA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 12 LEU A 225
LEU A 107
ILE A 111
GLU A 148
PHE A   3
 None
 1.04A 4y0rA-3zusA:
undetectable		 4y0rA-3zusA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 7 LEU A 345
GLY A 234
GLY A 179
ILE A 293
 None
 0.74A 4yjiA-3zusA:
undetectable		 4yjiA-3zusA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 12 VAL A 355
ASP A 352
GLU A 351
LEU A 208
PHE A 196
 None
 1.32A 5hnzB-3zusA:
undetectable		 5hnzB-3zusA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		5 / 10 ILE A 834
ILE A 687
ILE A 683
ILE A 682
ILE A 680
 None
 1.07A 5murE-3zusA:
2.9		 5murE-3zusA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		3 / 3 ASP A 275
PHE A 282
ARG A 241
 None
 1.10A 5yw0A-3zusA:
undetectable		 5yw0A-3zusA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		3 / 3 ASP A 511
PHE A 423
ARG A 605
 None
 0.75A 5yw0A-3zusA:
undetectable		 5yw0A-3zusA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 8 ILE A 130
THR A 132
LYS A  37
SER A 146
 None
 1.12A 6c06C-3zusA:
undetectable		 6c06C-3zusA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 4 LEU A  94
ASP A 216
PRO A 217
ARG A  97
 None
 1.41A 6fgdA-3zusA:
undetectable		 6fgdA-3zusA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 7 ARG A 264
TYR A 286
LEU A 284
TYR A 342
 None
 1.29A 6g2pA-3zusA:
undetectable		 6g2pA-3zusA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens) 		4 / 5 GLY A 181
LEU A 175
SER A 167
GLN A 184
 None
 1.02A 6ji6A-3zusA:
undetectable		 6ji6A-3zusA:
14.11