SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zuv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3zuv DESIGNED ANKYRIN
REPEAT PROTEIN
(synthetic
construct) 		4 / 4 LEU B  57
LEU B  51
GLN B  26
GLU B  61
 None
 1.23A 4i41A-3zuvB:
undetectable		 4i41A-3zuvB:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3zuv DESIGNED ANKYRIN
REPEAT PROTEIN
(synthetic
construct) 		4 / 8 ARG B  23
ASP B  46
LEU B  48
ILE B  81
 None
 1.05A 4k0bA-3zuvB:
undetectable		 4k0bA-3zuvB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3zuv DESIGNED ANKYRIN
REPEAT PROTEIN
(synthetic
construct) 		4 / 8 ARG B  23
ASP B  46
LEU B  48
ILE B  81
 None
 0.98A 4l7iA-3zuvB:
undetectable		 4l7iA-3zuvB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 3zuv DESIGNED ANKYRIN
REPEAT PROTEIN
(synthetic
construct) 		5 / 11 ILE B  95
LEU B  84
HIS B 102
LEU B 100
ALA B 104
 None
 1.12A 4p65E-3zuvB:
undetectable
4p65F-3zuvB:
undetectable
4p65J-3zuvB:
undetectable
4p65L-3zuvB:
undetectable		 4p65E-3zuvB:
7.46
4p65F-3zuvB:
13.08
4p65J-3zuvB:
13.08
4p65L-3zuvB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 3zuv DESIGNED ANKYRIN
REPEAT PROTEIN
(synthetic
construct) 		5 / 12 VAL B  30
LEU B  18
LEU B  51
ILE B  62
ALA B  71
 None
 1.02A 4p65B-3zuvB:
undetectable
4p65D-3zuvB:
undetectable
4p65I-3zuvB:
undetectable
4p65J-3zuvB:
undetectable		 4p65B-3zuvB:
13.08
4p65D-3zuvB:
13.08
4p65I-3zuvB:
7.46
4p65J-3zuvB:
13.08