SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zuz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3zuz PROTEIN SHQ1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 338
LEU A 434
ILE A 180
LEU A 285
PRO A 286
 None
 1.11A 2pnjA-3zuzA:
undetectable		 2pnjA-3zuzA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 3zuz PROTEIN SHQ1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 377
ARG A 374
ALA A 376
ILE A 466
 None
 0.97A 2qhfA-3zuzA:
undetectable		 2qhfA-3zuzA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3zuz PROTEIN SHQ1
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 192
ASP A 189
TYR A 423
 None
 0.79A 2yvlB-3zuzA:
undetectable		 2yvlB-3zuzA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 3zuz PROTEIN SHQ1
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 409
ILE A 271
GLY A 402
VAL A 252
ILE A 251
 None
 0.98A 3em3B-3zuzA:
undetectable		 3em3B-3zuzA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 3zuz PROTEIN SHQ1
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 409
ILE A 271
GLY A 402
VAL A 252
ILE A 251
 None
 1.02A 3nujA-3zuzA:
undetectable		 3nujA-3zuzA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 3zuz PROTEIN SHQ1
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 409
ILE A 271
GLY A 402
VAL A 252
ILE A 251
 None
 1.03A 3nuoA-3zuzA:
undetectable		 3nuoA-3zuzA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3zuz PROTEIN SHQ1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 273
GLY A 402
GLY A 401
GLU A 444
ILE A 447
 None
 1.40A 3owxA-3zuzA:
undetectable
3owxB-3zuzA:
undetectable		 3owxA-3zuzA:
22.01
3owxB-3zuzA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3zuz PROTEIN SHQ1
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 487
TYR A 225
GLU A 496
ILE A 493
 IPA  A1506 (-3.3A)
None
None
None
 0.64A 3q5sA-3zuzA:
undetectable		 3q5sA-3zuzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 3zuz PROTEIN SHQ1
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 306
SER A 304
LEU A 450
LEU A 410
 None
 1.01A 4n09A-3zuzA:
undetectable		 4n09A-3zuzA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3zuz PROTEIN SHQ1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 399
LEU A 303
THR A 371
ALA A 391
ILE A 369
 None
 0.98A 4x20B-3zuzA:
undetectable		 4x20B-3zuzA:
23.16