SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zvk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 3zvk TOXIN OF
TOXIN-ANTITOXIN
SYSTEM
(Rickettsia
felis) 		5 / 12 ILE A  34
GLY A   6
SER A  37
GLU A  69
ALA A 106
 None
 1.01A 1sg9C-3zvkA:
undetectable		 1sg9C-3zvkA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 3zvk TOXIN OF
TOXIN-ANTITOXIN
SYSTEM
(Rickettsia
felis) 		6 / 12 LEU A  84
LEU A 100
ILE A 102
PHE A 121
LEU A 127
LEU A  88
 None
 1.46A 1xdkF-3zvkA:
undetectable		 1xdkF-3zvkA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_A_SAMA500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 3zvk TOXIN OF
TOXIN-ANTITOXIN
SYSTEM
ANTITOXIN OF
TOXIN-ANTITOXIN
SYSTEM VAPB
(Rickettsia
felis;
Rickettsia
felis) 		5 / 10 SER A  59
SER A  66
SER E  29
LEU E  33
GLN A  58
 None
 1.40A 2c2bA-3zvkA:
0.5
2c2bB-3zvkA:
0.6		 2c2bA-3zvkA:
12.88
2c2bB-3zvkA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_B_SAMB500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 3zvk TOXIN OF
TOXIN-ANTITOXIN
SYSTEM
ANTITOXIN OF
TOXIN-ANTITOXIN
SYSTEM VAPB
(Rickettsia
felis;
Rickettsia
felis) 		5 / 10 LEU E  33
GLN A  58
SER A  59
SER A  66
SER E  29
 None
 1.36A 2c2bA-3zvkE:
0.0
2c2bB-3zvkE:
0.0		 2c2bA-3zvkE:
10.42
2c2bB-3zvkE:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_C_SAMC500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 3zvk TOXIN OF
TOXIN-ANTITOXIN
SYSTEM
ANTITOXIN OF
TOXIN-ANTITOXIN
SYSTEM VAPB
(Rickettsia
felis;
Rickettsia
felis) 		5 / 10 SER A  59
SER A  66
SER E  29
LEU E  33
GLN A  58
 None
 1.40A 2c2bC-3zvkA:
0.5
2c2bD-3zvkA:
0.6		 2c2bC-3zvkA:
12.88
2c2bD-3zvkA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_E_SAME500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 3zvk TOXIN OF
TOXIN-ANTITOXIN
SYSTEM
ANTITOXIN OF
TOXIN-ANTITOXIN
SYSTEM VAPB
(Rickettsia
felis;
Rickettsia
felis) 		5 / 11 SER A  59
SER A  66
SER E  29
LEU E  33
GLN A  58
 None
 1.39A 2c2bE-3zvkA:
undetectable
2c2bF-3zvkA:
3.1		 2c2bE-3zvkA:
12.88
2c2bF-3zvkA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_F_SAMF500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 3zvk TOXIN OF
TOXIN-ANTITOXIN
SYSTEM
ANTITOXIN OF
TOXIN-ANTITOXIN
SYSTEM VAPB
(Rickettsia
felis;
Rickettsia
felis) 		5 / 10 LEU E  33
GLN A  58
SER A  59
SER A  66
SER E  29
 None
 1.39A 2c2bE-3zvkE:
0.0
2c2bF-3zvkE:
0.0		 2c2bE-3zvkE:
10.42
2c2bF-3zvkE:
10.42