SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zwf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		4 / 5 HIS A  67
HIS A 182
HIS A 313
ASP A  66
 ZN  A1363 (-3.4A)
ZN  A1364 ( 3.5A)
ZN  A1363 ( 3.4A)
ZN  A1363 ( 2.6A)
 0.90A 1e9yB-3zwfA:
undetectable		 1e9yB-3zwfA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A  75
LEU A  74
HIS A 121
TYR A 118
ILE A  91
 None
None
None
EDO  A1368 (-3.5A)
None
 1.35A 1fmlA-3zwfA:
undetectable		 1fmlA-3zwfA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 10 PRO A  72
GLY A  73
LEU A  34
THR A  41
GLY A  38
 None
 1.31A 1h4oA-3zwfA:
undetectable
1h4oB-3zwfA:
undetectable		 1h4oA-3zwfA:
21.37
1h4oB-3zwfA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A  79
THR A 106
MET A 107
LEU A 114
 None
 0.80A 1lhvA-3zwfA:
undetectable		 1lhvA-3zwfA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 11 GLU A 275
HIS A  67
LEU A 123
HIS A  62
PRO A 185
 None
ZN  A1363 (-3.4A)
None
ZN  A1364 (-3.5A)
None
 1.45A 1mjqA-3zwfA:
undetectable
1mjqB-3zwfA:
undetectable		 1mjqA-3zwfA:
13.20
1mjqB-3zwfA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A 300
PHE A 178
VAL A 192
ALA A 306
ALA A 269
 None
 1.33A 1q23A-3zwfA:
undetectable
1q23B-3zwfA:
undetectable		 1q23A-3zwfA:
20.05
1q23B-3zwfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 11 GLY A 188
ALA A 177
ILE A 156
GLY A  95
ILE A  60
 None
 0.92A 2nnpA-3zwfA:
undetectable		 2nnpA-3zwfA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 12 THR A  61
LEU A  34
LEU A  71
GLY A  65
HIS A  64
 None
None
None
None
ZN  A1364 ( 3.2A)
 1.07A 2ouzA-3zwfA:
undetectable		 2ouzA-3zwfA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 11 ASP A  66
HIS A  67
HIS A 182
ASP A 253
HIS A 313
 ZN  A1363 ( 2.6A)
ZN  A1363 (-3.4A)
ZN  A1364 ( 3.5A)
ZN  A1363 (-2.5A)
ZN  A1363 ( 3.4A)
 0.67A 2q0jB-3zwfA:
9.7		 2q0jB-3zwfA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 11 HIS A  67
HIS A 182
ASP A 253
HIS A 313
SER A 315
 ZN  A1363 (-3.4A)
ZN  A1364 ( 3.5A)
ZN  A1363 (-2.5A)
ZN  A1363 ( 3.4A)
None
 0.93A 2q0jB-3zwfA:
9.7		 2q0jB-3zwfA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 188
ALA A 177
ILE A 156
GLY A  95
ILE A  60
 None
 0.89A 2q5kB-3zwfA:
undetectable		 2q5kB-3zwfA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 11 HIS A 313
HIS A 291
HIS A  64
HIS A  62
PRO A 131
 ZN  A1363 ( 3.4A)
PO4  A1365 (-3.8A)
ZN  A1364 ( 3.2A)
ZN  A1364 (-3.5A)
None
 1.48A 2zweA-3zwfA:
undetectable
2zweB-3zwfA:
undetectable		 2zweA-3zwfA:
21.16
2zweB-3zwfA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		4 / 6 HIS A  62
THR A  61
PHE A 187
LEU A 180
 ZN  A1364 (-3.5A)
None
None
None
 1.18A 3bgdA-3zwfA:
undetectable		 3bgdA-3zwfA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 8 HIS A  67
HIS A  62
ASP A  66
HIS A  64
GLY A  65
 ZN  A1363 (-3.4A)
ZN  A1364 (-3.5A)
ZN  A1363 ( 2.6A)
ZN  A1364 ( 3.2A)
None
 1.29A 3c0zB-3zwfA:
undetectable		 3c0zB-3zwfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 10 GLY A 188
ALA A 177
ILE A 156
GLY A  95
ILE A  60
 None
 0.89A 3el9B-3zwfA:
undetectable		 3el9B-3zwfA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 10 THR A  41
GLY A  73
GLU A  39
LEU A  74
LEU A  75
 None
 1.34A 3kvrA-3zwfA:
undetectable		 3kvrA-3zwfA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 10 THR A  41
GLY A  73
GLU A  39
LEU A  74
LEU A  75
 None
 1.33A 3kvrB-3zwfA:
undetectable		 3kvrB-3zwfA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 10 GLY A 188
ALA A 177
ILE A 156
GLY A  95
ILE A  60
 None
 0.97A 3lzvA-3zwfA:
undetectable		 3lzvA-3zwfA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 9 THR A  41
GLY A  73
GLU A  39
LEU A  74
LEU A  75
 None
 1.29A 3nbqA-3zwfA:
undetectable		 3nbqA-3zwfA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A 168
GLU A  92
ILE A  91
PHE A 116
THR A  56
 None
 1.17A 3ndiA-3zwfA:
undetectable		 3ndiA-3zwfA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 180
HIS A 313
GLU A 275
HIS A 291
 None
ZN  A1363 ( 3.4A)
None
PO4  A1365 (-3.8A)
 1.26A 4a7bB-3zwfA:
undetectable		 4a7bB-3zwfA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 10 HIS A  67
HIS A  62
ASP A  66
HIS A  64
GLY A  65
 ZN  A1363 (-3.4A)
ZN  A1364 (-3.5A)
ZN  A1363 ( 2.6A)
ZN  A1364 ( 3.2A)
None
 1.33A 4bz6A-3zwfA:
undetectable		 4bz6A-3zwfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 12 HIS A  67
HIS A  62
ASP A  66
HIS A  64
GLY A  65
 ZN  A1363 (-3.4A)
ZN  A1364 (-3.5A)
ZN  A1363 ( 2.6A)
ZN  A1364 ( 3.2A)
None
 1.34A 4bz6A-3zwfA:
undetectable
4bz6B-3zwfA:
undetectable		 4bz6A-3zwfA:
21.68
4bz6B-3zwfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 10 HIS A  67
HIS A  62
ASP A  66
HIS A  64
GLY A  65
 ZN  A1363 (-3.4A)
ZN  A1364 (-3.5A)
ZN  A1363 ( 2.6A)
ZN  A1364 ( 3.2A)
None
 1.33A 4bz6D-3zwfA:
undetectable		 4bz6D-3zwfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 10 HIS A  62
HIS A  64
ASP A  66
HIS A 182
HIS A 313
 ZN  A1364 (-3.5A)
ZN  A1364 ( 3.2A)
ZN  A1363 ( 2.6A)
ZN  A1364 ( 3.5A)
ZN  A1363 ( 3.4A)
 0.80A 4c1dB-3zwfA:
8.8		 4c1dB-3zwfA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 11 HIS A  62
HIS A  64
ASP A  66
HIS A 182
HIS A 313
 ZN  A1364 (-3.5A)
ZN  A1364 ( 3.2A)
ZN  A1363 ( 2.6A)
ZN  A1364 ( 3.5A)
ZN  A1363 ( 3.4A)
 0.80A 4c1fA-3zwfA:
9.4
4c1fB-3zwfA:
9.1		 4c1fA-3zwfA:
23.08
4c1fB-3zwfA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 9 HIS A  62
HIS A  64
ASP A  66
HIS A 182
HIS A 313
 ZN  A1364 (-3.5A)
ZN  A1364 ( 3.2A)
ZN  A1363 ( 2.6A)
ZN  A1364 ( 3.5A)
ZN  A1363 ( 3.4A)
 0.81A 4c1hA-3zwfA:
9.1		 4c1hA-3zwfA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 10 VAL A  24
ASP A 353
PHE A 354
VAL A  25
THR A  10
 None
 1.50A 4eilD-3zwfA:
undetectable		 4eilD-3zwfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		4 / 8 HIS A  64
ASP A  66
HIS A 182
HIS A 313
 ZN  A1364 ( 3.2A)
ZN  A1363 ( 2.6A)
ZN  A1364 ( 3.5A)
ZN  A1363 ( 3.4A)
 0.74A 4exsB-3zwfA:
9.5		 4exsB-3zwfA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		4 / 5 HIS A  67
HIS A 182
HIS A 313
ASP A  66
 ZN  A1363 (-3.4A)
ZN  A1364 ( 3.5A)
ZN  A1363 ( 3.4A)
ZN  A1363 ( 2.6A)
 0.92A 4h9mA-3zwfA:
undetectable		 4h9mA-3zwfA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 11 HIS A  67
HIS A  62
ASP A  66
HIS A  64
GLY A  65
 ZN  A1363 (-3.4A)
ZN  A1364 (-3.5A)
ZN  A1363 ( 2.6A)
ZN  A1364 ( 3.2A)
None
 1.32A 4lxzB-3zwfA:
undetectable		 4lxzB-3zwfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 12 CYH A 254
LEU A 309
GLY A 188
CYH A 249
GLY A 261
 None
 1.01A 4n09B-3zwfA:
undetectable		 4n09B-3zwfA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		4 / 7 HIS A 291
HIS A 313
HIS A  62
HIS A  64
 PO4  A1365 (-3.8A)
ZN  A1363 ( 3.4A)
ZN  A1364 (-3.5A)
ZN  A1364 ( 3.2A)
 0.94A 4p6sB-3zwfA:
undetectable		 4p6sB-3zwfA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 11 HIS A  67
HIS A  62
ASP A  66
HIS A  64
GLY A  65
 ZN  A1363 (-3.4A)
ZN  A1364 (-3.5A)
ZN  A1363 ( 2.6A)
ZN  A1364 ( 3.2A)
None
 1.34A 4qa0B-3zwfA:
undetectable		 4qa0B-3zwfA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		4 / 8 HIS A  64
ASP A  66
HIS A 182
HIS A 313
 ZN  A1364 ( 3.2A)
ZN  A1363 ( 2.6A)
ZN  A1364 ( 3.5A)
ZN  A1363 ( 3.4A)
 0.72A 5a5zA-3zwfA:
9.6		 5a5zA-3zwfA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		6 / 11 HIS A  62
HIS A  64
ASP A  66
HIS A  67
HIS A 182
HIS A 313
 ZN  A1364 (-3.5A)
ZN  A1364 ( 3.2A)
ZN  A1363 ( 2.6A)
ZN  A1363 (-3.4A)
ZN  A1364 ( 3.5A)
ZN  A1363 ( 3.4A)
 0.35A 5ayaA-3zwfA:
9.9		 5ayaA-3zwfA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 12 HIS A  67
HIS A  62
ASP A  66
HIS A  64
GLY A  65
 ZN  A1363 (-3.4A)
ZN  A1364 (-3.5A)
ZN  A1363 ( 2.6A)
ZN  A1364 ( 3.2A)
None
 1.32A 5eenA-3zwfA:
undetectable		 5eenA-3zwfA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		4 / 7 ILE A  58
THR A  77
ILE A  78
LEU A  71
 None
 0.73A 5fukA-3zwfA:
undetectable
5fukB-3zwfA:
undetectable		 5fukA-3zwfA:
18.97
5fukB-3zwfA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 12 ASP A 253
ILE A  60
SER A 186
LEU A 123
GLY A  70
 ZN  A1363 (-2.5A)
None
None
None
None
 0.89A 5i75A-3zwfA:
undetectable		 5i75A-3zwfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 359
VAL A 310
GLY A 252
THR A  61
PHE A  59
 None
 1.11A 5igiA-3zwfA:
undetectable		 5igiA-3zwfA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 12 SER A 292
HIS A 291
GLY A 252
HIS A 182
GLY A 188
 None
PO4  A1365 (-3.8A)
None
ZN  A1364 ( 3.5A)
None
 1.18A 5l6eA-3zwfA:
undetectable		 5l6eA-3zwfA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		4 / 8 ASP A 253
HIS A 313
HIS A 291
HIS A  62
 ZN  A1363 (-2.5A)
ZN  A1363 ( 3.4A)
PO4  A1365 (-3.8A)
ZN  A1364 (-3.5A)
 0.93A 5nekD-3zwfA:
undetectable		 5nekD-3zwfA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		6 / 10 HIS A  62
HIS A  64
HIS A  67
HIS A 182
ASP A 253
HIS A 291
 ZN  A1364 (-3.5A)
ZN  A1364 ( 3.2A)
ZN  A1363 (-3.4A)
ZN  A1364 ( 3.5A)
ZN  A1363 (-2.5A)
PO4  A1365 (-3.8A)
 0.30A 5nzwA-3zwfA:
10.2		 5nzwA-3zwfA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 10 HIS A  67
HIS A 313
HIS A  62
ASP A 253
HIS A 182
 ZN  A1363 (-3.4A)
ZN  A1363 ( 3.4A)
ZN  A1364 (-3.5A)
ZN  A1363 (-2.5A)
ZN  A1364 ( 3.5A)
 1.08A 5nzwA-3zwfA:
10.2		 5nzwA-3zwfA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		5 / 10 HIS A 182
HIS A  62
HIS A 291
ASP A 253
HIS A 313
 ZN  A1364 ( 3.5A)
ZN  A1364 (-3.5A)
PO4  A1365 (-3.8A)
ZN  A1363 (-2.5A)
ZN  A1363 ( 3.4A)
 0.97A 5nzwA-3zwfA:
10.2		 5nzwA-3zwfA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		3 / 3 HIS A  67
ASP A 253
HIS A 313
 ZN  A1363 (-3.4A)
ZN  A1363 (-2.5A)
ZN  A1363 ( 3.4A)
 0.81A 5oexA-3zwfA:
undetectable		 5oexA-3zwfA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		3 / 3 THR A 277
GLU A 275
HIS A 182
 None
None
ZN  A1364 ( 3.5A)
 0.79A 5xioA-3zwfA:
undetectable		 5xioA-3zwfA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		3 / 3 THR A 277
GLU A 275
HIS A 182
 None
None
ZN  A1364 ( 3.5A)
 0.82A 5xiqB-3zwfA:
undetectable		 5xiqB-3zwfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		3 / 3 THR A 277
GLU A 275
HIS A 182
 None
None
ZN  A1364 ( 3.5A)
 0.82A 5xiqD-3zwfA:
undetectable		 5xiqD-3zwfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		4 / 8 HIS A  64
ASP A  66
HIS A 182
HIS A 313
 ZN  A1364 ( 3.2A)
ZN  A1363 ( 2.6A)
ZN  A1364 ( 3.5A)
ZN  A1363 ( 3.4A)
 0.79A 5zj8A-3zwfA:
9.5		 5zj8A-3zwfA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens) 		3 / 3 HIS A  62
HIS A 182
ARG A 183
 ZN  A1364 (-3.5A)
ZN  A1364 ( 3.5A)
PO4  A1365 (-2.8A)
 1.12A 6b58A-3zwfA:
undetectable		 6b58A-3zwfA:
21.96