SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zxe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3zxe GALECTIN-7
(Homo
sapiens) 		4 / 4 LEU A  37
LEU A  48
SER A  63
LEU A 113
 None
 1.12A 1ya3A-3zxeA:
undetectable		 1ya3A-3zxeA:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 3zxe GALECTIN-7
(Homo
sapiens) 		6 / 6 HIS A  49
ASN A  51
ARG A  53
ASN A  62
TRP A  69
GLU A  72
 PGZ  A   1 (-3.9A)
PGZ  A   1 (-3.8A)
PGZ  A   1 (-3.6A)
PGZ  A   1 (-3.8A)
PGZ  A   1 (-4.0A)
PGZ  A   1 (-3.5A)
 0.29A 3galA-3zxeA:
27.1		 3galA-3zxeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 3zxe GALECTIN-7
(Homo
sapiens) 		6 / 6 HIS A  49
ASN A  51
ARG A  53
ASN A  62
TRP A  69
GLU A  72
 PGZ  A   1 (-3.9A)
PGZ  A   1 (-3.8A)
PGZ  A   1 (-3.6A)
PGZ  A   1 (-3.8A)
PGZ  A   1 (-4.0A)
PGZ  A   1 (-3.5A)
 0.32A 3galB-3zxeA:
26.6		 3galB-3zxeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 3zxe GALECTIN-7
(Homo
sapiens) 		4 / 7 ARG A  31
VAL A  60
GLU A  72
ARG A  74
 PGZ  A   1 ( 4.7A)
None
PGZ  A   1 (-3.5A)
None
 1.26A 4mv7A-3zxeA:
undetectable		 4mv7A-3zxeA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 3zxe GALECTIN-7
(Homo
sapiens) 		4 / 5 SER A  63
GLY A  70
GLU A  73
PHE A 109
 None
 1.27A 4r82A-3zxeA:
undetectable
4r82B-3zxeA:
undetectable		 4r82A-3zxeA:
23.66
4r82B-3zxeA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3zxe GALECTIN-7
(Homo
sapiens) 		4 / 6 PRO A  10
ARG A  14
THR A  17
ILE A 134
 None
 1.39A 5ih0A-3zxeA:
undetectable		 5ih0A-3zxeA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 3zxe GALECTIN-7
(Homo
sapiens) 		7 / 7 HIS A  49
ASN A  51
ARG A  53
ASN A  62
TRP A  69
GLU A  72
ARG A  74
 PGZ  A   1 (-3.9A)
PGZ  A   1 (-3.8A)
PGZ  A   1 (-3.6A)
PGZ  A   1 (-3.8A)
PGZ  A   1 (-4.0A)
PGZ  A   1 (-3.5A)
None
 0.62A 6b8kA-3zxeA:
23.1		 6b8kA-3zxeA:
25.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 3zxe GALECTIN-7
(Homo
sapiens) 		6 / 8 HIS A  49
ASN A  51
ARG A  53
ASN A  62
TRP A  69
GLU A  72
 PGZ  A   1 (-3.9A)
PGZ  A   1 (-3.8A)
PGZ  A   1 (-3.6A)
PGZ  A   1 (-3.8A)
PGZ  A   1 (-4.0A)
PGZ  A   1 (-3.5A)
 0.25A 6b94A-3zxeA:
20.2		 6b94A-3zxeA:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 3zxe GALECTIN-7
(Homo
sapiens) 		6 / 8 HIS A  49
ASN A  51
ARG A  53
TRP A  69
GLU A  72
ARG A  74
 PGZ  A   1 (-3.9A)
PGZ  A   1 (-3.8A)
PGZ  A   1 (-3.6A)
PGZ  A   1 (-4.0A)
PGZ  A   1 (-3.5A)
None
 0.62A 6b94A-3zxeA:
20.2		 6b94A-3zxeA:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_B_W9TB201_0
(GALECTIN-1)		 3zxe GALECTIN-7
(Homo
sapiens) 		7 / 10 HIS A  49
ASN A  51
ARG A  53
ASN A  62
TRP A  69
GLU A  72
ARG A  74
 PGZ  A   1 (-3.9A)
PGZ  A   1 (-3.8A)
PGZ  A   1 (-3.6A)
PGZ  A   1 (-3.8A)
PGZ  A   1 (-4.0A)
PGZ  A   1 (-3.5A)
None
 0.63A 6b94A-3zxeA:
20.2
6b94B-3zxeA:
19.5		 6b94A-3zxeA:
38.37
6b94B-3zxeA:
38.37