SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 3zxl HIAXHD3
(Humicola
insolens) 		4 / 6 TRP A 134
GLY A  65
ASN A 362
PRO A  67
 None
 1.11A 1dedA-3zxlA:
undetectable		 1dedA-3zxlA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 3zxl HIAXHD3
(Humicola
insolens) 		4 / 7 PHE A 390
PHE A 427
ALA A 392
PHE A 539
 None
 0.98A 1fxvA-3zxlA:
undetectable
1fxvB-3zxlA:
undetectable		 1fxvA-3zxlA:
16.87
1fxvB-3zxlA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 3zxl HIAXHD3
(Humicola
insolens) 		3 / 3 ALA A 102
VAL A 104
TRP A 108
 None
None
B3P  A1560 (-3.6A)
 1.02A 1gmkC-3zxlA:
undetectable
1gmkD-3zxlA:
undetectable		 1gmkC-3zxlA:
2.92
1gmkD-3zxlA:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3zxl HIAXHD3
(Humicola
insolens) 		4 / 5 GLU A  39
GLY A 402
SER A 342
THR A 343
 None
 1.13A 1icrA-3zxlA:
undetectable
1icrB-3zxlA:
undetectable		 1icrA-3zxlA:
16.57
1icrB-3zxlA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3zxl HIAXHD3
(Humicola
insolens) 		4 / 6 GLU A  39
GLY A 402
SER A 342
THR A 343
 None
 1.12A 1icuA-3zxlA:
undetectable
1icuB-3zxlA:
undetectable		 1icuA-3zxlA:
16.57
1icuB-3zxlA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3zxl HIAXHD3
(Humicola
insolens) 		4 / 5 SER A 342
THR A 343
GLU A  39
GLY A 402
 None
 1.12A 1icvC-3zxlA:
undetectable
1icvD-3zxlA:
undetectable		 1icvC-3zxlA:
16.57
1icvD-3zxlA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3zxl HIAXHD3
(Humicola
insolens) 		4 / 5 GLU A  39
GLY A 402
SER A 342
THR A 343
 None
 1.12A 1icvC-3zxlA:
undetectable
1icvD-3zxlA:
undetectable		 1icvC-3zxlA:
16.57
1icvD-3zxlA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3zxl HIAXHD3
(Humicola
insolens) 		4 / 5 GLU A  39
GLY A 402
SER A 342
THR A 343
 None
 1.17A 1kqbA-3zxlA:
undetectable
1kqbB-3zxlA:
undetectable		 1kqbA-3zxlA:
16.51
1kqbB-3zxlA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3zxl HIAXHD3
(Humicola
insolens) 		4 / 6 GLU A  39
GLY A 402
SER A 342
THR A 343
 None
 1.15A 1kqbC-3zxlA:
undetectable
1kqbD-3zxlA:
undetectable		 1kqbC-3zxlA:
16.51
1kqbD-3zxlA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3zxl HIAXHD3
(Humicola
insolens) 		3 / 3 ALA A 468
VAL A 448
TRP A 437
 None
 0.75A 1kqeA-3zxlA:
undetectable
1kqeE-3zxlA:
undetectable		 1kqeA-3zxlA:
2.00
1kqeE-3zxlA:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 3zxl HIAXHD3
(Humicola
insolens) 		3 / 3 ALA A 468
VAL A 448
TRP A 437
 None
 0.76A 1kqeB-3zxlA:
undetectable
1kqeD-3zxlA:
undetectable		 1kqeB-3zxlA:
2.00
1kqeD-3zxlA:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 3zxl HIAXHD3
(Humicola
insolens) 		3 / 3 TRP A 437
ALA A 468
VAL A 448
 None
 0.78A 1kqeB-3zxlA:
undetectable
1kqeD-3zxlA:
undetectable		 1kqeB-3zxlA:
2.00
1kqeD-3zxlA:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 3zxl HIAXHD3
(Humicola
insolens) 		3 / 3 TRP A 437
ALA A 468
VAL A 448
 None
 0.76A 1kqeA-3zxlA:
undetectable
1kqeE-3zxlA:
undetectable		 1kqeA-3zxlA:
2.00
1kqeE-3zxlA:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_B_RIOB501_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 3zxl HIAXHD3
(Humicola
insolens) 		5 / 9 ASP A  43
GLU A 358
GLY A  65
SER A  56
ASP A  40
 B3P  A1560 (-2.7A)
None
None
None
None
 1.27A 1m4gB-3zxlA:
undetectable		 1m4gB-3zxlA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 3zxl HIAXHD3
(Humicola
insolens) 		4 / 7 TYR A 326
TRP A 322
HIS A 272
GLY A 269
 None
None
B3P  A1560 ( 4.7A)
None
 1.23A 1mxgA-3zxlA:
undetectable		 1mxgA-3zxlA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 3zxl HIAXHD3
(Humicola
insolens) 		4 / 7 ALA A 218
ASP A 167
GLY A 275
ILE A 276
 None
B3P  A1560 (-2.9A)
None
None
 0.76A 1t7iB-3zxlA:
undetectable		 1t7iB-3zxlA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 3zxl HIAXHD3
(Humicola
insolens) 		4 / 7 ALA A 218
ASP A 167
GLY A 275
ILE A 276
 None
B3P  A1560 (-2.9A)
None
None
 0.76A 1t7jB-3zxlA:
undetectable		 1t7jB-3zxlA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 3zxl HIAXHD3
(Humicola
insolens) 		5 / 12 LEU A 380
VAL A 413
GLY A 435
VAL A 550
VAL A 548
 None
 0.74A 2ieoB-3zxlA:
undetectable		 2ieoB-3zxlA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 3zxl HIAXHD3
(Humicola
insolens) 		5 / 11 LEU A 380
VAL A 413
GLY A 435
VAL A 550
VAL A 548
 None
 0.73A 2nnpB-3zxlA:
undetectable		 2nnpB-3zxlA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 3zxl HIAXHD3
(Humicola
insolens) 		4 / 5 LEU A 389
LEU A 426
MET A 447
THR A 460
 None
 1.42A 2oaxD-3zxlA:
undetectable		 2oaxD-3zxlA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 3zxl HIAXHD3
(Humicola
insolens) 		3 / 3 LEU A 265
MET A 290
MET A 522
 None
 1.05A 2vavF-3zxlA:
undetectable		 2vavF-3zxlA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 3zxl HIAXHD3
(Humicola
insolens) 		4 / 5 VAL A  36
VAL A 300
PHE A  53
ARG A 297
 None
None
None
B3P  A1560 (-2.8A)
 1.34A 3bjwH-3zxlA:
undetectable		 3bjwH-3zxlA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3zxl HIAXHD3
(Humicola
insolens) 		3 / 3 VAL A  68
SER A  83
LEU A 112
 None
 0.71A 3n8xA-3zxlA:
undetectable		 3n8xA-3zxlA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3zxl HIAXHD3
(Humicola
insolens) 		3 / 3 TYR A  62
ASP A  40
ASP A 291
 None
None
B3P  A1560 (-2.7A)
 0.87A 3ou6B-3zxlA:
undetectable		 3ou6B-3zxlA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 3zxl HIAXHD3
(Humicola
insolens) 		5 / 12 LEU A 241
GLY A 217
ALA A 218
GLY A 275
ILE A 229
 None
 1.04A 3oxxC-3zxlA:
undetectable		 3oxxC-3zxlA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 3zxl HIAXHD3
(Humicola
insolens) 		5 / 10 ALA A 218
ASP A 167
GLY A 275
ILE A 276
LEU A 171
 None
B3P  A1560 (-2.9A)
None
None
None
 0.96A 3ttpA-3zxlA:
undetectable		 3ttpA-3zxlA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 3zxl HIAXHD3
(Humicola
insolens) 		5 / 10 ALA A 218
ASP A 167
GLY A 275
ILE A 276
LEU A 171
 None
B3P  A1560 (-2.9A)
None
None
None
 0.91A 3ttpB-3zxlA:
undetectable		 3ttpB-3zxlA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 3zxl HIAXHD3
(Humicola
insolens) 		5 / 9 ALA A 218
ASP A 167
GLY A 275
ILE A 276
LEU A 171
 None
B3P  A1560 (-2.9A)
None
None
None
 0.99A 3u7sB-3zxlA:
undetectable		 3u7sB-3zxlA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 3zxl HIAXHD3
(Humicola
insolens) 		5 / 9 ALA A 218
ASP A 167
GLY A 275
ILE A 276
LEU A 171
 None
B3P  A1560 (-2.9A)
None
None
None
 0.99A 3u7sB-3zxlA:
undetectable		 3u7sB-3zxlA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3zxl HIAXHD3
(Humicola
insolens) 		5 / 11 VAL A 548
PHE A 537
LEU A 483
VAL A 413
THR A 382
 None
 1.44A 4eilA-3zxlA:
undetectable		 4eilA-3zxlA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3zxl HIAXHD3
(Humicola
insolens) 		5 / 11 VAL A 548
PHE A 537
LEU A 483
VAL A 413
THR A 382
 None
 1.45A 4eilC-3zxlA:
undetectable		 4eilC-3zxlA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3zxl HIAXHD3
(Humicola
insolens) 		5 / 11 VAL A 548
PHE A 537
LEU A 483
VAL A 413
THR A 382
 None
 1.44A 4eilE-3zxlA:
undetectable		 4eilE-3zxlA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 3zxl HIAXHD3
(Humicola
insolens) 		3 / 3 LYS A 551
ARG A 410
TRP A 482
 None
 1.19A 4i90A-3zxlA:
undetectable		 4i90A-3zxlA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3zxl HIAXHD3
(Humicola
insolens) 		4 / 5 LEU A 171
VAL A 206
VAL A 231
TYR A 227
 None
 0.97A 4r7iA-3zxlA:
undetectable		 4r7iA-3zxlA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y9T_A_PA1A401_1
(ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN)		 3zxl HIAXHD3
(Humicola
insolens) 		5 / 12 ASP A 291
PHE A 289
ASP A  43
ALA A 235
GLN A 273
 B3P  A1560 (-2.7A)
None
B3P  A1560 (-2.7A)
B3P  A1560 (-2.2A)
B3P  A1560 ( 4.1A)
 1.11A 4y9tA-3zxlA:
undetectable		 4y9tA-3zxlA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3zxl HIAXHD3
(Humicola
insolens) 		4 / 5 SER A  58
ARG A 527
GLU A 455
ARG A 297
 B3P  A1560 ( 3.9A)
None
None
B3P  A1560 (-2.8A)
 1.09A 5cdqR-3zxlA:
undetectable
5cdqS-3zxlA:
undetectable
5cdqT-3zxlA:
undetectable		 5cdqR-3zxlA:
19.93
5cdqS-3zxlA:
14.34
5cdqT-3zxlA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 3zxl HIAXHD3
(Humicola
insolens) 		4 / 7 SER A  58
PHE A  60
TRP A 458
TYR A 293
 B3P  A1560 ( 3.9A)
B3P  A1560 (-4.2A)
None
B3P  A1560 (-4.1A)
 1.31A 5dlvB-3zxlA:
undetectable		 5dlvB-3zxlA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 3zxl HIAXHD3
(Humicola
insolens) 		4 / 5 GLY A 531
ASP A  40
ARG A 533
MET A 557
 None
 1.39A 5gwkA-3zxlA:
undetectable		 5gwkA-3zxlA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 3zxl HIAXHD3
(Humicola
insolens) 		4 / 5 SER A  83
VAL A  84
GLY A  65
ALA A  66
 None
 0.90A 5k50A-3zxlA:
undetectable		 5k50A-3zxlA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3zxl HIAXHD3
(Humicola
insolens) 		3 / 3 ARG A 515
ILE A 485
PHE A 503
 None
 0.73A 5kirA-3zxlA:
undetectable		 5kirA-3zxlA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 3zxl HIAXHD3
(Humicola
insolens) 		4 / 8 THR A 501
THR A 502
TYR A 504
PRO A 403
 None
 1.27A 5x2sI-3zxlA:
undetectable
5x2sJ-3zxlA:
undetectable
5x2sK-3zxlA:
undetectable		 5x2sI-3zxlA:
12.41
5x2sJ-3zxlA:
13.79
5x2sK-3zxlA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 3zxl HIAXHD3
(Humicola
insolens) 		5 / 12 LEU A 380
VAL A 413
GLY A 435
VAL A 550
VAL A 548
 None
 0.87A 6dh0A-3zxlA:
undetectable		 6dh0A-3zxlA:
10.44