SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zxo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 3zxo REDOX SENSOR
HISTIDINE KINASE
RESPONSE REGULATOR
DEVS
(Mycobacterium
tuberculosis) 		5 / 12 GLN A 492
GLY A 555
GLN A 578
PHE A 557
ALA A 574
 None
 1.02A 3t7sA-3zxoA:
undetectable		 3t7sA-3zxoA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3zxo REDOX SENSOR
HISTIDINE KINASE
RESPONSE REGULATOR
DEVS
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 485
LEU A 456
LEU A 482
ILE A 525
 None
None
None
OCS  A 524 ( 4.0A)
 0.87A 3u5kA-3zxoA:
undetectable		 3u5kA-3zxoA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3zxo REDOX SENSOR
HISTIDINE KINASE
RESPONSE REGULATOR
DEVS
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 485
LEU A 456
LEU A 482
ILE A 525
 None
None
None
OCS  A 524 ( 4.0A)
 0.87A 3u5kC-3zxoA:
undetectable		 3u5kC-3zxoA:
16.67