SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zxs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 4 HIS A 214
LEU A  74
LEU A  52
LEU A 270
 None
 1.24A 1a4lD-3zxsA:
undetectable		 1a4lD-3zxsA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 8 SER A 422
VAL A 421
TYR A 337
VAL A 383
 None
 0.96A 1fduB-3zxsA:
undetectable		 1fduB-3zxsA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		3 / 3 ARG A  89
ARG A  90
ILE A  83
 None
 0.70A 1uobA-3zxsA:
undetectable		 1uobA-3zxsA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 6 LEU A 455
TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
None
SF4  A1510 (-4.5A)
None
 1.36A 1v54A-3zxsA:
undetectable
1v54J-3zxsA:
undetectable		 1v54A-3zxsA:
22.32
1v54J-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 7 LEU A 455
TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
None
SF4  A1510 (-4.5A)
None
 1.33A 1v55A-3zxsA:
undetectable
1v55J-3zxsA:
undetectable		 1v55A-3zxsA:
22.32
1v55J-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 357
ALA A 358
LEU A 263
ARG A 193
THR A 369
 None
None
FAD  A1509 (-4.4A)
None
None
 1.35A 1ya3A-3zxsA:
undetectable		 1ya3A-3zxsA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		3 / 3 TRP A 172
GLU A 148
TYR A 151
 None
 1.26A 2a3aA-3zxsA:
undetectable		 2a3aA-3zxsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 357
ALA A 358
LEU A 263
ARG A 193
THR A 369
 None
None
FAD  A1509 (-4.4A)
None
None
 1.40A 2aa5A-3zxsA:
undetectable		 2aa5A-3zxsA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 357
ALA A 358
LEU A 263
ARG A 193
THR A 369
 None
None
FAD  A1509 (-4.4A)
None
None
 1.41A 2aa5B-3zxsA:
undetectable		 2aa5B-3zxsA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 357
ALA A 358
LEU A 263
ARG A 193
THR A 369
 None
None
FAD  A1509 (-4.4A)
None
None
 1.38A 2aa6A-3zxsA:
undetectable		 2aa6A-3zxsA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 357
ALA A 358
LEU A 263
ARG A 193
THR A 369
 None
None
FAD  A1509 (-4.4A)
None
None
 1.40A 2aa6B-3zxsA:
undetectable		 2aa6B-3zxsA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 9 PHE A 452
LEU A 502
HIS A 503
LEU A 336
ALA A 373
 None
 1.20A 2bxeA-3zxsA:
undetectable		 2bxeA-3zxsA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 7 SER A 431
ARG A 188
LEU A 259
GLU A 248
 None
 1.05A 2cdqB-3zxsA:
3.8		 2cdqB-3zxsA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 6 LEU A 455
TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
None
SF4  A1510 (-4.5A)
None
 1.39A 2dyrA-3zxsA:
undetectable
2dyrJ-3zxsA:
undetectable		 2dyrA-3zxsA:
22.32
2dyrJ-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 6 LEU A 455
TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
None
SF4  A1510 (-4.5A)
None
 1.38A 2dysA-3zxsA:
undetectable
2dysJ-3zxsA:
undetectable		 2dysA-3zxsA:
22.32
2dysJ-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 6 LEU A 455
TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
None
SF4  A1510 (-4.5A)
None
 1.32A 2dysN-3zxsA:
undetectable
2dysW-3zxsA:
undetectable		 2dysN-3zxsA:
22.32
2dysW-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 6 LEU A 455
TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
None
SF4  A1510 (-4.5A)
None
 1.36A 2eijA-3zxsA:
undetectable
2eijJ-3zxsA:
undetectable		 2eijA-3zxsA:
22.32
2eijJ-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 6 LEU A 455
TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
None
SF4  A1510 (-4.5A)
None
 1.32A 2eilA-3zxsA:
undetectable
2eilJ-3zxsA:
undetectable		 2eilA-3zxsA:
22.32
2eilJ-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 5 TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
SF4  A1510 (-4.5A)
None
 1.19A 2eimJ-3zxsA:
undetectable		 2eimJ-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 5 TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
SF4  A1510 (-4.5A)
None
 1.19A 2eimW-3zxsA:
undetectable		 2eimW-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 206
ASP A  76
THR A  79
ARG A  56
GLU A  33
 None
 1.39A 2j1gE-3zxsA:
undetectable
2j1gF-3zxsA:
undetectable		 2j1gE-3zxsA:
15.65
2j1gF-3zxsA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 357
ALA A 358
LEU A 263
ARG A 193
THR A 369
 None
None
FAD  A1509 (-4.4A)
None
None
 1.37A 2oaxF-3zxsA:
undetectable		 2oaxF-3zxsA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 12 ALA A 376
PHE A 452
SER A 423
THR A 342
TYR A 337
 None
 1.02A 2oipC-3zxsA:
2.2		 2oipC-3zxsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 6 LEU A 455
TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
None
SF4  A1510 (-4.5A)
None
 1.42A 3abmA-3zxsA:
undetectable
3abmJ-3zxsA:
undetectable		 3abmA-3zxsA:
22.32
3abmJ-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 5 TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
SF4  A1510 (-4.5A)
None
 1.22A 3ag1J-3zxsA:
undetectable		 3ag1J-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 5 TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
SF4  A1510 (-4.5A)
None
 1.17A 3ag2J-3zxsA:
undetectable		 3ag2J-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 7 LEU A 455
TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
None
SF4  A1510 (-4.5A)
None
 1.34A 3ag3A-3zxsA:
undetectable
3ag3J-3zxsA:
undetectable		 3ag3A-3zxsA:
22.32
3ag3J-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 5 TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
SF4  A1510 (-4.5A)
None
 1.25A 3ag4J-3zxsA:
undetectable		 3ag4J-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 7 LEU A 502
PHE A 498
TYR A 439
MET A 344
 None
None
None
SF4  A1510 (-4.5A)
 1.05A 3ag4N-3zxsA:
undetectable
3ag4W-3zxsA:
undetectable		 3ag4N-3zxsA:
22.32
3ag4W-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 6 LEU A 455
TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
None
SF4  A1510 (-4.5A)
None
 1.38A 3asnA-3zxsA:
undetectable
3asnJ-3zxsA:
undetectable		 3asnA-3zxsA:
22.32
3asnJ-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 6 LEU A 455
TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
None
SF4  A1510 (-4.5A)
None
 1.38A 3asoA-3zxsA:
undetectable
3asoJ-3zxsA:
undetectable		 3asoA-3zxsA:
22.32
3asoJ-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 12 ALA A 376
PHE A 452
SER A 423
THR A 342
TYR A 337
 None
 1.07A 3hj3A-3zxsA:
2.6		 3hj3A-3zxsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 12 ALA A 376
PHE A 452
SER A 423
THR A 342
TYR A 337
 None
 1.04A 3hj3C-3zxsA:
2.4		 3hj3C-3zxsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		3 / 3 SER A 260
ASP A 256
ASP A 247
 None
 0.78A 3iv6A-3zxsA:
1.7		 3iv6A-3zxsA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 8 TYR A 387
ALA A 360
ALA A 350
LEU A 336
 FAD  A1509 (-3.5A)
None
None
None
 1.06A 3l4dD-3zxsA:
undetectable		 3l4dD-3zxsA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 8 GLY A 405
LEU A 414
LEU A 415
ILE A 313
 None
 0.91A 3nbqB-3zxsA:
undetectable		 3nbqB-3zxsA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 11 GLY A 274
GLU A 277
LEU A 231
ARG A 232
LEU A 272
 None
 1.23A 3ndvA-3zxsA:
undetectable
3ndvB-3zxsA:
undetectable		 3ndvA-3zxsA:
24.21
3ndvB-3zxsA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 11 GLY A 274
GLU A 277
LEU A 231
ARG A 232
LEU A 272
 None
 1.24A 3ndvA-3zxsA:
undetectable
3ndvB-3zxsA:
undetectable		 3ndvA-3zxsA:
24.21
3ndvB-3zxsA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 11 GLY A 274
GLU A 277
LEU A 231
ARG A 232
LEU A 272
 None
 1.22A 3ndvC-3zxsA:
undetectable
3ndvD-3zxsA:
undetectable		 3ndvC-3zxsA:
24.21
3ndvD-3zxsA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 8 ILE A 392
GLN A  46
ALA A  49
LEU A  50
 None
 0.54A 3ozwA-3zxsA:
4.5		 3ozwA-3zxsA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		3 / 3 HIS A  43
HIS A 214
ILE A  48
 DLZ  A1511 ( 3.9A)
None
DLZ  A1511 ( 4.6A)
 0.82A 3u52A-3zxsA:
undetectable
3u52C-3zxsA:
undetectable		 3u52A-3zxsA:
18.66
3u52C-3zxsA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 6 PHE A 372
ALA A 376
PRO A 335
LEU A 502
 None
 0.92A 4dtzA-3zxsA:
undetectable		 4dtzA-3zxsA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 6 PHE A 372
ALA A 376
PRO A 335
LEU A 502
 None
 0.88A 4dtzB-3zxsA:
undetectable		 4dtzB-3zxsA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 6 PHE A 372
ALA A 376
PRO A 335
LEU A 502
 None
 0.95A 4dubB-3zxsA:
undetectable		 4dubB-3zxsA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 7 GLN A 353
TYR A 359
LEU A 259
ASP A 256
 None
FAD  A1509 (-4.6A)
None
None
 1.20A 4hxyB-3zxsA:
undetectable		 4hxyB-3zxsA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA608_0
(SERUM ALBUMIN)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 4 PRO A  17
ASP A  15
LEU A  16
ARG A 127
 None
 1.39A 4luhA-3zxsA:
0.0		 4luhA-3zxsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 12 ALA A  18
GLN A  11
VAL A  34
LEU A 109
LEU A 113
 None
None
DLZ  A1511 (-4.5A)
None
None
 1.05A 4qzuC-3zxsA:
undetectable		 4qzuC-3zxsA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		3 / 3 ARG A 488
ASP A 481
TRP A 480
 None
 1.21A 4xdqA-3zxsA:
undetectable		 4xdqA-3zxsA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 12 THR A 354
LEU A 357
ALA A 358
LEU A 263
ARG A 193
 None
None
None
FAD  A1509 (-4.4A)
None
 1.00A 4xi3C-3zxsA:
undetectable		 4xi3C-3zxsA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 7 LEU A 455
TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
None
SF4  A1510 (-4.5A)
None
 1.37A 5b1aA-3zxsA:
undetectable
5b1aJ-3zxsA:
undetectable		 5b1aA-3zxsA:
22.32
5b1aJ-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 7 PHE A 498
TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
None
SF4  A1510 (-4.5A)
None
 1.30A 5b1bN-3zxsA:
undetectable
5b1bW-3zxsA:
undetectable		 5b1bN-3zxsA:
22.32
5b1bW-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 7 LEU A 455
TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
None
SF4  A1510 (-4.5A)
None
 1.37A 5b3sA-3zxsA:
undetectable
5b3sJ-3zxsA:
undetectable		 5b3sA-3zxsA:
22.32
5b3sJ-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 7 PHE A 498
TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
None
SF4  A1510 (-4.5A)
None
 1.26A 5b3sN-3zxsA:
undetectable
5b3sW-3zxsA:
undetectable		 5b3sN-3zxsA:
22.32
5b3sW-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 7 TYR A 387
GLY A 370
SER A 407
LEU A 366
 FAD  A1509 (-3.5A)
None
FAD  A1509 ( 4.4A)
FAD  A1509 ( 4.2A)
 1.14A 5bphB-3zxsA:
2.6		 5bphB-3zxsA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 9 LEU A 129
THR A 158
LEU A 160
ILE A 300
LEU A 161
 None
 1.32A 5g48B-3zxsA:
undetectable		 5g48B-3zxsA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 12 THR A 354
LEU A 357
ALA A 358
LEU A 263
ARG A 193
 None
None
None
FAD  A1509 (-4.4A)
None
 0.98A 5gs4A-3zxsA:
undetectable		 5gs4A-3zxsA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 113
ALA A 101
ILE A  51
ILE A  83
LEU A 395
 None
None
DLZ  A1511 (-4.0A)
None
DLZ  A1511 ( 4.4A)
 1.16A 5h8tA-3zxsA:
undetectable		 5h8tA-3zxsA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 7 PHE A 498
TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
None
SF4  A1510 (-4.5A)
None
 1.32A 5iy5N-3zxsA:
undetectable
5iy5W-3zxsA:
undetectable		 5iy5N-3zxsA:
22.32
5iy5W-3zxsA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		3 / 3 PRO A 189
ARG A 244
GLU A 240
 None
 0.97A 5j6hA-3zxsA:
undetectable		 5j6hA-3zxsA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 12 GLU A 177
LEU A 293
ASP A 247
GLY A 246
LYS A 171
 None
 1.41A 5kc4A-3zxsA:
undetectable		 5kc4A-3zxsA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 5 ASP A 106
ARG A 108
LEU A  52
MET A  55
 None
None
None
DLZ  A1511 ( 3.7A)
 1.15A 5tuiB-3zxsA:
undetectable		 5tuiB-3zxsA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 5 TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
SF4  A1510 (-4.5A)
None
 1.15A 5w97J-3zxsA:
undetectable		 5w97J-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 5 TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
SF4  A1510 (-4.5A)
None
 1.20A 5wauJ-3zxsA:
undetectable		 5wauJ-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 5 TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
SF4  A1510 (-4.5A)
None
 1.25A 5x1fW-3zxsA:
undetectable		 5x1fW-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 12 TYR A 151
GLY A 298
GLY A 305
ASN A 178
ASP A 247
 None
 1.38A 5yn6A-3zxsA:
undetectable		 5yn6A-3zxsA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		3 / 3 ASP A  10
PHE A 128
ARG A 307
 DLZ  A1511 (-2.5A)
None
None
 1.15A 5yw0A-3zxsA:
undetectable		 5yw0A-3zxsA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zxs CRYPTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 5 TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
SF4  A1510 (-4.5A)
None
 1.15A 5z86J-3zxsA:
undetectable		 5z86J-3zxsA:
8.48