SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 12 LEU A 101
ALA A 149
THR A 217
THR A 221
TYR A 190
 None
 0.90A 1cbsA-3zxyA:
undetectable		 1cbsA-3zxyA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 12 ALA A 150
THR A 124
LEU A 133
TYR A 190
THR A 221
 None
 1.17A 1dhfA-3zxyA:
undetectable		 1dhfA-3zxyA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 12 ALA A 150
THR A 124
LEU A 133
TYR A 190
THR A 221
 None
 1.11A 1dhfB-3zxyA:
undetectable		 1dhfB-3zxyA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 12 ALA A 150
THR A 124
LEU A 133
TYR A 190
THR A 221
 None
 1.10A 1dyiB-3zxyA:
undetectable		 1dyiB-3zxyA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		4 / 8 PHE A  67
SER A 225
ALA A 229
ILE A 115
 None
 1.16A 1gm7A-3zxyA:
undetectable
1gm7B-3zxyA:
undetectable		 1gm7A-3zxyA:
23.47
1gm7B-3zxyA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		4 / 8 PHE A  67
SER A 225
ALA A 229
ILE A 115
 None
 1.20A 1pnlA-3zxyA:
undetectable
1pnlB-3zxyA:
undetectable		 1pnlA-3zxyA:
23.47
1pnlB-3zxyA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 12 GLY A  59
HIS A  58
GLY A  53
ASP A  91
VAL A  26
 None
 1.17A 1qu2A-3zxyA:
undetectable		 1qu2A-3zxyA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 11 VAL A 137
VAL A 168
GLU A 106
LEU A  22
ILE A 118
 None
 1.27A 1t6zA-3zxyA:
undetectable		 1t6zA-3zxyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 11 VAL A 137
VAL A 168
GLU A 106
LEU A  22
ILE A 118
 None
 1.33A 1t6zB-3zxyA:
undetectable		 1t6zB-3zxyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		4 / 8 ARG A 238
ASN A  16
HIS A 114
VAL A 236
 None
 1.13A 1u1jA-3zxyA:
2.2		 1u1jA-3zxyA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 12 ALA A 197
ILE A 195
ILE A 223
VAL A 227
ILE A 115
 None
 1.11A 1xozA-3zxyA:
undetectable		 1xozA-3zxyA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 12 LEU A 101
ALA A 149
THR A 217
THR A 221
TYR A 190
 None
 0.86A 2fr3A-3zxyA:
undetectable		 2fr3A-3zxyA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 12 ILE A  65
VAL A 227
ALA A 228
LEU A 169
ILE A 115
 None
 1.15A 2h42B-3zxyA:
undetectable		 2h42B-3zxyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 10 ALA A 150
THR A 124
LEU A 133
TYR A 190
THR A 221
 None
 1.14A 2w3aB-3zxyA:
undetectable		 2w3aB-3zxyA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		3 / 3 ASN A 117
ASP A  23
ARG A 213
 None
 0.80A 3k13C-3zxyA:
undetectable		 3k13C-3zxyA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 12 ALA A 150
THR A 124
LEU A 133
TYR A 190
THR A 221
 None
 1.24A 4cd2A-3zxyA:
undetectable		 4cd2A-3zxyA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 12 ALA A 150
THR A 124
LEU A 133
TYR A 190
THR A 221
 None
 1.14A 4ej1B-3zxyA:
undetectable		 4ej1B-3zxyA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 12 ALA A 150
THR A 124
LEU A 133
TYR A 190
THR A 221
 None
 1.09A 4pstA-3zxyA:
undetectable		 4pstA-3zxyA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 12 ALA A 150
THR A 124
LEU A 133
TYR A 190
THR A 221
 None
 1.07A 4pthA-3zxyA:
undetectable		 4pthA-3zxyA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 12 ALA A 150
THR A 124
LEU A 133
TYR A 190
THR A 221
 None
 1.11A 4qleA-3zxyA:
undetectable		 4qleA-3zxyA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 12 ALA A 150
THR A 124
LEU A 133
TYR A 190
THR A 221
 None
 1.11A 4x5fA-3zxyA:
undetectable		 4x5fA-3zxyA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 12 ALA A 150
THR A 124
LEU A 133
TYR A 190
THR A 221
 None
 1.12A 4x5fB-3zxyA:
undetectable		 4x5fB-3zxyA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 12 ALA A 150
THR A 124
LEU A 133
TYR A 190
THR A 221
 None
 1.13A 4x5gA-3zxyA:
undetectable		 4x5gA-3zxyA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		5 / 10 LEU A 146
ALA A 228
SER A 254
LEU A 282
ALA A 279
 None
 1.12A 4zbrA-3zxyA:
undetectable		 4zbrA-3zxyA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		4 / 6 VAL A 168
LEU A 101
ILE A 118
ALA A 149
 None
 0.73A 4zf8A-3zxyA:
undetectable		 4zf8A-3zxyA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		4 / 8 ILE A  88
ALA A 108
VAL A 109
ARG A 107
 None
 0.90A 6hu9a-3zxyA:
undetectable
6hu9e-3zxyA:
undetectable		 6hu9a-3zxyA:
20.86
6hu9e-3zxyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3zxy SUBTILISIN-LIKE
PROTEIN
(Prochloron
didemni) 		3 / 3 ASN A 144
PRO A 244
GLN A 235
 None
 0.96A 6jogA-3zxyA:
undetectable		 6jogA-3zxyA:
23.61