SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zy3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 3zy3 PUTATIVE GDP-FUCOSE
PROTEIN
O-FUCOSYLTRANSFERASE
1
(Caenorhabditis
elegans) 		4 / 5 VAL A 354
ASN A 352
VAL A 248
ILE A 252
 None
 0.76A 1z2bC-3zy3A:
undetectable		 1z2bC-3zy3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 3zy3 PUTATIVE GDP-FUCOSE
PROTEIN
O-FUCOSYLTRANSFERASE
1
(Caenorhabditis
elegans) 		4 / 8 GLY A 165
PHE A 192
ILE A 163
SER A 174
 None
 1.03A 2a8tB-3zy3A:
undetectable		 2a8tB-3zy3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 3zy3 PUTATIVE GDP-FUCOSE
PROTEIN
O-FUCOSYLTRANSFERASE
1
(Caenorhabditis
elegans) 		4 / 6 LYS A 285
GLN A 287
LEU A 289
GLU A 290
 None
 1.07A 3h5gB-3zy3A:
undetectable
3h5gC-3zy3A:
undetectable		 3h5gB-3zy3A:
6.69
3h5gC-3zy3A:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 3zy3 PUTATIVE GDP-FUCOSE
PROTEIN
O-FUCOSYLTRANSFERASE
1
(Caenorhabditis
elegans) 		4 / 8 GLY A 156
PHE A  54
PHE A 118
PHE A 192
 None
 1.07A 3ko0D-3zy3A:
undetectable
3ko0E-3zy3A:
undetectable		 3ko0D-3zy3A:
16.10
3ko0E-3zy3A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 3zy3 PUTATIVE GDP-FUCOSE
PROTEIN
O-FUCOSYLTRANSFERASE
1
(Caenorhabditis
elegans) 		4 / 8 PHE A 118
PHE A 192
GLY A 156
PHE A  54
 None
 1.06A 3ko0B-3zy3A:
undetectable
3ko0J-3zy3A:
undetectable		 3ko0B-3zy3A:
16.10
3ko0J-3zy3A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 3zy3 PUTATIVE GDP-FUCOSE
PROTEIN
O-FUCOSYLTRANSFERASE
1
(Caenorhabditis
elegans) 		4 / 7 GLY A 156
PHE A  54
PHE A 118
PHE A 192
 None
 1.11A 3ko0L-3zy3A:
undetectable
3ko0N-3zy3A:
undetectable		 3ko0L-3zy3A:
16.10
3ko0N-3zy3A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 3zy3 PUTATIVE GDP-FUCOSE
PROTEIN
O-FUCOSYLTRANSFERASE
1
(Caenorhabditis
elegans) 		4 / 7 PHE A 118
PHE A 192
GLY A 156
PHE A  54
 None
 1.09A 3ko0K-3zy3A:
undetectable
3ko0S-3zy3A:
undetectable		 3ko0K-3zy3A:
16.10
3ko0S-3zy3A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 3zy3 PUTATIVE GDP-FUCOSE
PROTEIN
O-FUCOSYLTRANSFERASE
1
(Caenorhabditis
elegans) 		4 / 7 PHE A 118
PHE A 192
GLY A 156
PHE A  54
 None
 1.12A 3ko0R-3zy3A:
undetectable
3ko0T-3zy3A:
undetectable		 3ko0R-3zy3A:
16.10
3ko0T-3zy3A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zy3 PUTATIVE GDP-FUCOSE
PROTEIN
O-FUCOSYLTRANSFERASE
1
(Caenorhabditis
elegans) 		4 / 8 ASN A 318
GLU A 316
ILE A 317
ASP A 311
 None
 1.10A 4d39A-3zy3A:
undetectable		 4d39A-3zy3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 3zy3 PUTATIVE GDP-FUCOSE
PROTEIN
O-FUCOSYLTRANSFERASE
1
(Caenorhabditis
elegans) 		4 / 6 THR A 356
GLY A  42
PHE A  41
ILE A  68
 GDP  A1384 (-2.9A)
GDP  A1384 (-3.1A)
None
None
 0.95A 5kmfA-3zy3A:
undetectable
5kmfC-3zy3A:
undetectable		 5kmfA-3zy3A:
20.77
5kmfC-3zy3A:
20.77