SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zyi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		5 / 11 ILE A 208
SER A 226
GLY A 227
ASN A 276
GLY A 204
 None
 1.42A 1ho5A-3zyiA:
undetectable		 1ho5A-3zyiA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		5 / 12 LEU A 104
PHE A  95
LEU A 125
ILE A  87
VAL A 170
 None
 1.19A 1hrkA-3zyiA:
undetectable		 1hrkA-3zyiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		5 / 12 LEU A 104
PHE A  95
LEU A 125
ILE A  87
VAL A 170
 None
 1.23A 1hrkB-3zyiA:
undetectable		 1hrkB-3zyiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		3 / 3 TRP A 310
PHE A 286
TRP A 314
 None
 1.37A 1r15C-3zyiA:
undetectable		 1r15C-3zyiA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		3 / 3 TRP A 310
PHE A 286
TRP A 314
 None
 1.36A 1r15F-3zyiA:
undetectable		 1r15F-3zyiA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		3 / 3 TRP A 310
PHE A 286
TRP A 314
 None
 1.35A 1r15G-3zyiA:
undetectable		 1r15G-3zyiA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		3 / 3 TRP A 310
PHE A 286
TRP A 314
 None
 1.36A 1r15H-3zyiA:
undetectable		 1r15H-3zyiA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		5 / 12 PHE A 230
ILE A 257
VAL A 249
PHE A 262
LEU A 265
 None
 1.28A 2ft9A-3zyiA:
undetectable		 2ft9A-3zyiA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		5 / 12 LEU A 104
PHE A  95
LEU A 125
ILE A  87
VAL A 170
 None
 1.13A 2hrcA-3zyiA:
undetectable		 2hrcA-3zyiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		5 / 12 LEU A 104
PHE A  95
LEU A 125
ILE A  87
VAL A 170
 None
 1.15A 2hrcB-3zyiA:
undetectable		 2hrcB-3zyiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		5 / 12 LEU A 104
PHE A  95
LEU A 125
ILE A  87
VAL A 170
 None
 1.16A 2pnjB-3zyiA:
undetectable		 2pnjB-3zyiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		5 / 12 LEU A 104
PHE A  95
LEU A 125
ILE A  87
VAL A 170
 None
 1.21A 2po7A-3zyiA:
undetectable		 2po7A-3zyiA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		5 / 12 LEU A 104
PHE A  95
LEU A 125
ILE A  87
VAL A 170
 None
 1.23A 2po7B-3zyiA:
undetectable		 2po7B-3zyiA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		4 / 7 ASP A 307
ALA A 430
PRO A 378
THR A 376
 None
 0.92A 2q6oA-3zyiA:
undetectable		 2q6oA-3zyiA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		5 / 12 LEU A 104
PHE A  95
LEU A 125
ILE A  87
VAL A 170
 None
 1.18A 3aqiB-3zyiA:
undetectable		 3aqiB-3zyiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_A_DMOA551_1
(ARGINASE-1)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		5 / 9 HIS A  97
ASN A 120
HIS A  99
GLY A 121
ASP A  93
 None
 1.45A 3gn0A-3zyiA:
undetectable		 3gn0A-3zyiA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_B_DMOB552_1
(ARGINASE-1)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		5 / 9 HIS A  97
ASN A 120
HIS A  99
GLY A 121
ASP A  93
 None
 1.50A 3gn0B-3zyiA:
undetectable		 3gn0B-3zyiA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		4 / 7 PRO A 139
GLY A 141
ALA A 142
ALA A  92
 None
 0.77A 3ur0B-3zyiA:
undetectable		 3ur0B-3zyiA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		5 / 12 LEU A 104
PHE A  95
LEU A 125
ILE A  87
VAL A 170
 None
 1.17A 3w1wA-3zyiA:
undetectable		 3w1wA-3zyiA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		5 / 12 LEU A 104
PHE A  95
LEU A 125
ILE A  87
VAL A 170
 None
 1.20A 3w1wB-3zyiA:
undetectable		 3w1wB-3zyiA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		4 / 7 ASN A  81
GLN A 105
VAL A 103
GLU A 129
 None
 1.18A 4mv7A-3zyiA:
undetectable		 4mv7A-3zyiA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		5 / 12 GLY A 420
LEU A 386
ASN A 440
ARG A 360
LEU A 372
 None
None
None
NAG  A1442 ( 4.7A)
None
 1.45A 5emlA-3zyiA:
undetectable		 5emlA-3zyiA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		3 / 3 THR A  77
THR A  94
LEU A 106
 None
 0.50A 5m66D-3zyiA:
undetectable		 5m66D-3zyiA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A 142
GLY A 141
SER A 140
PHE A 119
LEU A 104
 None
 0.84A 5w7pA-3zyiA:
undetectable		 5w7pA-3zyiA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		4 / 5 ILE A  73
THR A  77
THR A  94
LEU A 106
 None
 0.78A 6f3mD-3zyiA:
undetectable		 6f3mD-3zyiA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens) 		4 / 6 PHE A 262
LEU A 285
ALA A 261
ASN A 276
 None
 1.00A 6f88A-3zyiA:
undetectable		 6f88A-3zyiA:
8.89