SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zyj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
NETRIN-G1
(Homo
sapiens) 		5 / 9 MET B  82
ARG A 156
GLY A 228
GLU A 181
SER A 227
 None
 1.24A 1pk9B-3zyjB:
undetectable		 1pk9B-3zyjB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
NETRIN-G1
(Homo
sapiens) 		4 / 7 THR A 128
ASN B  90
LEU A  80
GLN A 106
 None
 1.10A 1qzrA-3zyjA:
undetectable		 1qzrA-3zyjA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
NETRIN-G1
(Homo
sapiens) 		4 / 7 THR A 128
ASN B  90
LEU A  80
GLN A 106
 None
 1.02A 1qzrB-3zyjA:
undetectable		 1qzrB-3zyjA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
(Homo
sapiens) 		4 / 8 PHE A 239
LEU A 248
ILE A 296
ILE A 272
 None
 0.88A 1sbrA-3zyjA:
undetectable		 1sbrA-3zyjA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
(Homo
sapiens) 		3 / 3 ASN A 214
TYR A 166
SER A 189
 None
 0.94A 2gvcB-3zyjA:
undetectable		 2gvcB-3zyjA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
(Homo
sapiens) 		3 / 3 ASN A 214
TYR A 166
SER A 189
 None
 0.91A 2gvcE-3zyjA:
undetectable		 2gvcE-3zyjA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
(Homo
sapiens) 		5 / 12 LEU A 248
PHE A 239
LEU A 269
ILE A 255
PRO A 289
 None
 1.35A 2pnjB-3zyjA:
undetectable		 2pnjB-3zyjA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
(Homo
sapiens) 		4 / 8 ILE A 112
LEU A  83
LEU A  81
PHE A 120
 None
 0.85A 2vctA-3zyjA:
undetectable		 2vctA-3zyjA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
(Homo
sapiens) 		5 / 12 GLU A 271
VAL A 270
GLN A 246
TRP A 249
ASP A 222
 None
 1.48A 2vqyA-3zyjA:
undetectable		 2vqyA-3zyjA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
NETRIN-G1
(Homo
sapiens;
Homo
sapiens) 		4 / 8 THR A 128
TYR A 201
TYR B  86
CYH B  88
 None
 1.23A 2xz5A-3zyjA:
undetectable
2xz5C-3zyjA:
undetectable		 2xz5A-3zyjA:
17.82
2xz5C-3zyjA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
NETRIN-G1
(Homo
sapiens) 		4 / 6 HIS A 300
HIS A 276
HIS A 299
ASP B 168
 None
 1.17A 3nvcA-3zyjA:
undetectable		 3nvcA-3zyjA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3zyj NETRIN-G1
(Homo
sapiens) 		4 / 6 GLY B 282
VAL B 281
ASP B 168
THR B 190
 None
 0.92A 3vqrA-3zyjB:
undetectable		 3vqrA-3zyjB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3zyj NETRIN-G1
(Homo
sapiens) 		4 / 5 GLY B 282
VAL B 281
ASP B 168
THR B 190
 None
 0.90A 3vqrB-3zyjB:
undetectable		 3vqrB-3zyjB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
NETRIN-G1
(Homo
sapiens) 		3 / 3 ASN B  84
TRP A 154
ASP A 225
 None
 1.09A 4a7tA-3zyjB:
undetectable
4a7tF-3zyjB:
undetectable		 4a7tA-3zyjB:
16.71
4a7tF-3zyjB:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
NETRIN-G1
(Homo
sapiens) 		5 / 11 MET B  82
ARG A 156
GLY A 228
GLU A 181
SER A 227
 None
 1.29A 4d9hA-3zyjB:
undetectable		 4d9hA-3zyjB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
(Homo
sapiens) 		5 / 12 ILE A  91
LEU A  67
ILE A  74
PRO A  48
LEU A  81
 None
 1.12A 4gh8A-3zyjA:
undetectable		 4gh8A-3zyjA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OMW_D_TE4D202_1
(BETA-LACTOGLOBULIN)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
(Homo
sapiens) 		5 / 9 ASN A 208
ASN A 229
ALA A 205
GLN A 252
SER A 253
 None
 1.38A 4omwD-3zyjA:
undetectable		 4omwD-3zyjA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 3zyj NETRIN-G1
(Homo
sapiens) 		5 / 12 LEU B  65
ILE B 274
ILE B 160
VAL B 142
ILE B 144
 None
 0.85A 4q1xB-3zyjB:
undetectable		 4q1xB-3zyjB:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
(Homo
sapiens) 		4 / 4 THR A  76
GLY A  73
ASP A  72
SER A  75
 None
 1.30A 4rfqA-3zyjA:
undetectable		 4rfqA-3zyjA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 3zyj NETRIN-G1
(Homo
sapiens) 		5 / 12 ASP B 237
PHE B 266
PHE B 267
ILE B 235
PHE B 233
 None
 1.37A 4wh5A-3zyjB:
undetectable		 4wh5A-3zyjB:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
NETRIN-G1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 SER B 228
GLU B 283
GLU A 223
 None
 0.86A 4ymgB-3zyjB:
undetectable		 4ymgB-3zyjB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
(Homo
sapiens) 		4 / 6 GLY A 180
GLU A 181
ARG A 156
ASN A 157
 None
 1.24A 4zbqA-3zyjA:
undetectable		 4zbqA-3zyjA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zyj NETRIN-G1
(Homo
sapiens) 		4 / 7 ILE B 160
ARG B 275
THR B 145
LEU B 146
 None
NAG  B1370 (-3.2A)
None
None
 0.99A 5b3sA-3zyjB:
undetectable
5b3sJ-3zyjB:
undetectable		 5b3sA-3zyjB:
22.06
5b3sJ-3zyjB:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
(Homo
sapiens) 		5 / 12 GLY A 180
GLU A 194
PHE A 144
SER A 189
ILE A 188
 None
 1.18A 5igyA-3zyjA:
undetectable		 5igyA-3zyjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
(Homo
sapiens) 		5 / 12 GLY A 180
GLU A 194
PHE A 144
SER A 189
ILE A 188
 None
 1.12A 5ih0A-3zyjA:
undetectable		 5ih0A-3zyjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 3zyj NETRIN-G1
(Homo
sapiens) 		4 / 6 TYR B 178
THR B 151
ASP B 271
GLY B 179
 None
 1.20A 5mraA-3zyjB:
undetectable
5mraB-3zyjB:
undetectable		 5mraA-3zyjB:
18.90
5mraB-3zyjB:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
(Homo
sapiens) 		4 / 6 PHE A 263
ILE A 212
LEU A 215
PHE A 193
 None
 1.05A 5vkqA-3zyjA:
undetectable
5vkqD-3zyjA:
undetectable		 5vkqA-3zyjA:
13.73
5vkqD-3zyjA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zyj NETRIN-G1
(Homo
sapiens) 		4 / 7 ILE B 160
ARG B 275
THR B 145
LEU B 146
 None
NAG  B1370 (-3.2A)
None
None
 0.85A 5xdqA-3zyjB:
undetectable
5xdqJ-3zyjB:
undetectable		 5xdqA-3zyjB:
22.06
5xdqJ-3zyjB:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
(Homo
sapiens) 		5 / 12 ASN A 277
ASN A 301
LEU A 274
ASN A 273
GLY A 228
 None
 1.18A 6dwnA-3zyjA:
undetectable		 6dwnA-3zyjA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
NETRIN-G1
(Homo
sapiens;
Homo
sapiens) 		5 / 12 SER B 228
ASN A 277
ASN A 301
LEU A 274
GLY A 228
 None
 1.24A 6dwnA-3zyjB:
undetectable		 6dwnA-3zyjB:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
NETRIN-G1
(Homo
sapiens;
Homo
sapiens) 		4 / 6 VAL A  63
ASN A  82
ASN B  89
GLU A 130
 None
 1.24A 6h7uA-3zyjA:
undetectable		 6h7uA-3zyjA:
22.79