SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zyn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 12 ILE A 116
LEU A 143
LEU A 162
ASN A 122
VAL A 124
 None
 1.30A 1mrlB-3zynA:
undetectable
1mrlC-3zynA:
undetectable		 1mrlB-3zynA:
18.27
1mrlC-3zynA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 12 LEU A 302
VAL A 267
LEU A 284
LEU A 262
LEU A 291
 None
 1.32A 1mx1E-3zynA:
undetectable		 1mx1E-3zynA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		3 / 3 TRP A 323
PHE A 299
TRP A 327
 None
 1.09A 1r15C-3zynA:
undetectable		 1r15C-3zynA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		3 / 3 TRP A 323
PHE A 299
TRP A 327
 None
 1.07A 1r15F-3zynA:
undetectable		 1r15F-3zynA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		3 / 3 TRP A 323
PHE A 299
TRP A 327
 None
 1.07A 1r15G-3zynA:
undetectable		 1r15G-3zynA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		3 / 3 TRP A 323
PHE A 299
TRP A 327
 None
 1.08A 1r15H-3zynA:
undetectable		 1r15H-3zynA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		4 / 4 GLN A 154
GLU A 128
ILE A 127
PRO A 152
 None
 1.34A 2fcnA-3zynA:
undetectable		 2fcnA-3zynA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 12 PHE A 275
LEU A 214
LEU A 236
ILE A 200
THR A 228
 None
 1.01A 2v0mC-3zynA:
undetectable		 2v0mC-3zynA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		6 / 10 LEU A 305
LEU A 324
LEU A 310
VAL A 308
ILE A 270
THR A 331
 None
 1.43A 2w9gA-3zynA:
undetectable		 2w9gA-3zynA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		4 / 6 PRO A 152
ILE A 175
ASN A 170
LEU A 194
 None
 1.16A 2wekB-3zynA:
undetectable		 2wekB-3zynA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 12 ILE A 246
LEU A 243
LEU A 236
ASN A 215
LEU A 284
 None
 0.99A 3a50D-3zynA:
undetectable		 3a50D-3zynA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		6 / 11 LEU A 305
LEU A 324
LEU A 310
VAL A 308
ILE A 270
THR A 331
 None
 1.41A 3frbX-3zynA:
undetectable		 3frbX-3zynA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		4 / 8 SER A 325
ASP A 320
ASP A 357
TYR A 364
 None
 1.27A 3havA-3zynA:
undetectable		 3havA-3zynA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 10 VAL A 183
LEU A 135
PHE A 132
GLN A  96
LEU A 143
 None
 1.23A 3j6gB-3zynA:
undetectable		 3j6gB-3zynA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 10 VAL A 183
LEU A 135
PHE A 132
GLN A  96
LEU A 143
 None
 1.23A 3j6gD-3zynA:
undetectable		 3j6gD-3zynA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 10 VAL A 183
LEU A 135
PHE A 132
GLN A  96
LEU A 143
 None
 1.23A 3j6gF-3zynA:
undetectable		 3j6gF-3zynA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 10 VAL A 183
LEU A 135
PHE A 132
GLN A  96
LEU A 143
 None
 1.23A 3j6gH-3zynA:
undetectable		 3j6gH-3zynA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 10 VAL A 183
LEU A 135
PHE A 132
GLN A  96
LEU A 143
 None
 1.23A 3j6gJ-3zynA:
undetectable		 3j6gJ-3zynA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 10 VAL A 183
LEU A 135
PHE A 132
GLN A  96
LEU A 143
 None
 1.23A 3j6gL-3zynA:
undetectable		 3j6gL-3zynA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 10 VAL A 183
LEU A 135
PHE A 132
GLN A  96
LEU A 143
 None
 1.23A 3j6gN-3zynA:
undetectable		 3j6gN-3zynA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 10 VAL A 183
LEU A 135
PHE A 132
GLN A  96
LEU A 143
 None
 1.23A 3j6gP-3zynA:
undetectable		 3j6gP-3zynA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 10 VAL A 183
LEU A 135
PHE A 132
GLN A  96
LEU A 143
 None
 1.23A 3j6gR-3zynA:
undetectable		 3j6gR-3zynA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		3 / 3 ASP A 190
GLU A 235
SER A 120
 None
 0.83A 3p2kA-3zynA:
undetectable		 3p2kA-3zynA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		3 / 3 HIS A 296
SER A 325
ASN A 318
 None
 0.76A 3s8pB-3zynA:
undetectable		 3s8pB-3zynA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 12 LEU A 278
LEU A 236
LEU A 254
THR A 255
ARG A 304
 None
 1.17A 5hnwB-3zynA:
undetectable		 5hnwB-3zynA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 12 LEU A 278
LEU A 236
LEU A 254
THR A 255
ARG A 304
 None
 1.23A 5hnyB-3zynA:
undetectable		 5hnyB-3zynA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 12 LEU A 284
LEU A 236
LEU A 262
ASN A 241
ILE A 246
 None
 1.06A 5itzB-3zynA:
undetectable		 5itzB-3zynA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		3 / 3 THR A  90
THR A 107
LEU A 119
 None
 0.58A 5m66D-3zynA:
undetectable		 5m66D-3zynA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 12 LEU A 284
LEU A 236
LEU A 262
ASN A 241
ILE A 246
 None
 1.10A 5mioB-3zynA:
undetectable		 5mioB-3zynA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 12 ASN A 289
ASN A 313
LEU A 286
ASN A 285
GLY A 240
 None
 1.18A 6dwnA-3zynA:
undetectable		 6dwnA-3zynA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		4 / 5 ILE A  86
THR A  90
THR A 107
LEU A 119
 None
 0.75A 6f3mD-3zynA:
undetectable		 6f3mD-3zynA:
21.02