SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 10 THR A 153
ALA A 155
PHE A 132
LEU A 191
ILE A 172
 None
 1.20A 1claA-3zyoA:
undetectable		 1claA-3zyoA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		4 / 8 LEU A 405
LEU A 399
SER A 450
THR A 452
 None
 0.79A 1dvtA-3zyoA:
undetectable
1dvtB-3zyoA:
3.0		 1dvtA-3zyoA:
14.36
1dvtB-3zyoA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 12 ILE A 116
LEU A 143
LEU A 162
ASN A 122
VAL A 124
 None
 1.26A 1mrlB-3zyoA:
undetectable
1mrlC-3zyoA:
undetectable		 1mrlB-3zyoA:
16.43
1mrlC-3zyoA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		3 / 3 TRP A 323
PHE A 299
TRP A 327
 None
 1.22A 1r15C-3zyoA:
undetectable		 1r15C-3zyoA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		3 / 3 TRP A 323
PHE A 299
TRP A 327
 None
 1.20A 1r15F-3zyoA:
undetectable		 1r15F-3zyoA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		3 / 3 TRP A 323
PHE A 299
TRP A 327
 None
 1.20A 1r15G-3zyoA:
undetectable		 1r15G-3zyoA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		3 / 3 TRP A 323
PHE A 299
TRP A 327
 None
 1.21A 1r15H-3zyoA:
undetectable		 1r15H-3zyoA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		4 / 6 THR A 391
SER A 293
ASP A 320
PRO A 295
 None
 1.30A 2hdnI-3zyoA:
undetectable
2hdnJ-3zyoA:
undetectable
2hdnL-3zyoA:
undetectable		 2hdnI-3zyoA:
7.19
2hdnJ-3zyoA:
21.12
2hdnL-3zyoA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		4 / 6 THR A 391
SER A 293
ASP A 320
PRO A 295
 None
 1.30A 2hdnJ-3zyoA:
undetectable
2hdnK-3zyoA:
undetectable
2hdnL-3zyoA:
undetectable		 2hdnJ-3zyoA:
21.12
2hdnK-3zyoA:
7.19
2hdnL-3zyoA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		6 / 10 LEU A 305
LEU A 324
LEU A 310
VAL A 308
ILE A 270
THR A 331
 None
 1.48A 2w9gA-3zyoA:
undetectable		 2w9gA-3zyoA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 12 LEU A 214
ASN A 241
ILE A 175
THR A 153
LEU A 167
 None
 1.45A 3a51B-3zyoA:
undetectable		 3a51B-3zyoA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		6 / 11 LEU A 305
LEU A 324
LEU A 310
VAL A 308
ILE A 270
THR A 331
 None
 1.45A 3frbX-3zyoA:
undetectable		 3frbX-3zyoA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		3 / 3 ASP A 190
GLU A 235
SER A 120
 None
 0.85A 3p2kA-3zyoA:
undetectable		 3p2kA-3zyoA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 10 LEU A 143
LEU A 167
LEU A 191
ILE A 127
VAL A 183
 None
 1.39A 4mk4A-3zyoA:
undetectable		 4mk4A-3zyoA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 12 PHE A 299
ILE A 270
LEU A 291
LEU A 328
LEU A 324
 None
 1.19A 4qynB-3zyoA:
undetectable		 4qynB-3zyoA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 11 GLY A 403
ILE A 415
LEU A 423
LEU A 385
MET A 439
 None
 1.17A 4xumB-3zyoA:
undetectable		 4xumB-3zyoA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 11 LEU A 324
LEU A 262
LEU A 281
LEU A 305
LEU A 260
 None
 1.03A 4zowA-3zyoA:
undetectable		 4zowA-3zyoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 12 LEU A 284
LEU A 236
LEU A 262
ASN A 241
ILE A 246
 None
 1.14A 5eypB-3zyoA:
undetectable		 5eypB-3zyoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 12 LEU A 284
LEU A 236
LEU A 262
ASN A 241
ILE A 246
 None
 1.18A 5nm5B-3zyoA:
undetectable		 5nm5B-3zyoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		3 / 3 THR A 391
THR A 394
ARG A 272
 None
 0.94A 5wm2A-3zyoA:
undetectable		 5wm2A-3zyoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 12 ALA A 131
VAL A 151
ALA A 179
LEU A 189
LEU A 167
 None
 1.09A 5xxiA-3zyoA:
undetectable		 5xxiA-3zyoA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		5 / 12 ASN A 289
ASN A 313
LEU A 286
ASN A 285
GLY A 240
 None
 1.23A 6dwnA-3zyoA:
undetectable		 6dwnA-3zyoA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B
(Mus
musculus) 		4 / 5 ILE A  86
THR A  90
THR A 107
LEU A 119
 None
 0.92A 6f3mD-3zyoA:
undetectable		 6f3mD-3zyoA:
20.91