SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zyp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3zyp CIP1
(Trichoderma
reesei) 		5 / 12 ILE A  87
THR A 153
ILE A 151
LEU A 145
THR A  85
 None
None
None
None
PEG  A1224 (-3.2A)
 1.11A 1ddsA-3zypA:
undetectable		 1ddsA-3zypA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3zyp CIP1
(Trichoderma
reesei) 		5 / 12 ILE A  87
THR A 153
ILE A 151
LEU A 145
THR A  85
 None
None
None
None
PEG  A1224 (-3.2A)
 1.10A 1dyiA-3zypA:
undetectable		 1dyiA-3zypA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3zyp CIP1
(Trichoderma
reesei) 		5 / 12 ILE A  87
THR A 153
ILE A 151
LEU A 145
THR A  85
 None
None
None
None
PEG  A1224 (-3.2A)
 1.12A 1dyiB-3zypA:
undetectable		 1dyiB-3zypA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3zyp CIP1
(Trichoderma
reesei) 		4 / 7 THR A  59
GLY A  58
PHE A  57
ILE A 208
 None
PEG  A1223 (-4.5A)
None
None
 0.81A 2y7wC-3zypA:
undetectable		 2y7wC-3zypA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3zyp CIP1
(Trichoderma
reesei) 		5 / 12 ILE A  88
ILE A  87
VAL A  44
VAL A 203
PHE A  57
 None
 1.15A 2ygpA-3zypA:
undetectable		 2ygpA-3zypA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3zyp CIP1
(Trichoderma
reesei) 		4 / 6 ILE A 151
PHE A  86
PHE A 141
TYR A 143
 None
 1.29A 3elzB-3zypA:
undetectable		 3elzB-3zypA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3zyp CIP1
(Trichoderma
reesei) 		3 / 3 SER A   8
ASP A   5
ASP A  11
 None
 0.73A 3iv6A-3zypA:
undetectable		 3iv6A-3zypA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3zyp CIP1
(Trichoderma
reesei) 		3 / 3 SER A   8
ASP A   5
ASP A  11
 None
 0.76A 3iv6C-3zypA:
undetectable		 3iv6C-3zypA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 3zyp CIP1
(Trichoderma
reesei) 		4 / 7 GLY A 188
PHE A 191
GLY A  58
PHE A  57
 PEG  A1223 (-3.6A)
None
PEG  A1223 (-4.5A)
None
 0.92A 3ko0M-3zypA:
undetectable
3ko0P-3zypA:
undetectable		 3ko0M-3zypA:
16.20
3ko0P-3zypA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3zyp CIP1
(Trichoderma
reesei) 		5 / 12 ILE A  87
THR A 153
ILE A 151
LEU A 145
THR A  85
 None
None
None
None
PEG  A1224 (-3.2A)
 1.13A 4ej1B-3zypA:
undetectable		 4ej1B-3zypA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 3zyp CIP1
(Trichoderma
reesei) 		4 / 7 ASP A 206
ARG A  70
PHE A 138
HIS A  36
 CA  A1220 (-2.2A)
PEG  A1225 (-4.1A)
PEG  A1227 ( 4.6A)
None
 1.39A 4o4dA-3zypA:
undetectable		 4o4dA-3zypA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3zyp CIP1
(Trichoderma
reesei) 		5 / 12 ILE A  87
THR A 153
ILE A 151
LEU A 145
THR A  85
 None
None
None
None
PEG  A1224 (-3.2A)
 1.09A 4pthA-3zypA:
undetectable		 4pthA-3zypA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3zyp CIP1
(Trichoderma
reesei) 		5 / 12 ILE A  87
THR A 153
ILE A 151
LEU A 145
THR A  85
 None
None
None
None
PEG  A1224 (-3.2A)
 1.13A 4qleA-3zypA:
undetectable		 4qleA-3zypA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3zyp CIP1
(Trichoderma
reesei) 		5 / 12 ILE A  87
THR A 153
ILE A 151
LEU A 145
THR A  85
 None
None
None
None
PEG  A1224 (-3.2A)
 1.10A 4qlgB-3zypA:
undetectable		 4qlgB-3zypA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3zyp CIP1
(Trichoderma
reesei) 		5 / 12 ILE A  87
THR A 153
ILE A 151
LEU A 145
THR A  85
 None
None
None
None
PEG  A1224 (-3.2A)
 1.12A 4x5hA-3zypA:
undetectable		 4x5hA-3zypA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3zyp CIP1
(Trichoderma
reesei) 		5 / 12 ILE A  87
THR A 153
ILE A 151
LEU A 145
THR A  85
 None
None
None
None
PEG  A1224 (-3.2A)
 1.07A 5e8qB-3zypA:
undetectable		 5e8qB-3zypA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3zyp CIP1
(Trichoderma
reesei) 		5 / 12 ILE A  87
THR A 153
ILE A 151
LEU A 145
THR A  85
 None
None
None
None
PEG  A1224 (-3.2A)
 1.08A 5eajB-3zypA:
undetectable		 5eajB-3zypA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3zyp CIP1
(Trichoderma
reesei) 		5 / 12 ILE A  87
THR A 153
ILE A 151
LEU A 145
THR A  85
 None
None
None
None
PEG  A1224 (-3.2A)
 1.05A 5ujxB-3zypA:
undetectable		 5ujxB-3zypA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3zyp CIP1
(Trichoderma
reesei) 		4 / 7 ASP A 174
ASP A 121
GLY A 126
ASN A 171
 None
 1.12A 5x7pA-3zypA:
7.1		 5x7pA-3zypA:
11.26