SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zyx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 7 THR A 201
THR A 327
GLY A 313
ASP A 329
None
0.76A 1bu5A-3zyxA:
2.3
1bu5A-3zyxA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 8 THR A 201
THR A 327
GLY A 313
ASP A 329
None
0.72A 1bu5B-3zyxA:
2.6
1bu5B-3zyxA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 11 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.83A 1c6yA-3zyxA:
undetectable
1c6yA-3zyxA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 11 ARG A  70
LEU A  71
GLU A 444
ALA A 439
GLY A 434
None
None
None
FAD  A 600 (-3.5A)
FAD  A 600 (-4.3A)
1.34A 1cmaA-3zyxA:
undetectable
1cmaB-3zyxA:
undetectable
1cmaA-3zyxA:
12.23
1cmaB-3zyxA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 10 ALA A 439
GLY A 434
ARG A  70
LEU A  71
GLU A 444
FAD  A 600 (-3.5A)
FAD  A 600 (-4.3A)
None
None
None
1.32A 1cmcA-3zyxA:
undetectable
1cmcB-3zyxA:
undetectable
1cmcA-3zyxA:
12.23
1cmcB-3zyxA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 10 ARG A  70
LEU A  71
GLU A 444
ALA A 439
GLY A 434
None
None
None
FAD  A 600 (-3.5A)
FAD  A 600 (-4.3A)
1.30A 1cmcA-3zyxA:
undetectable
1cmcB-3zyxA:
undetectable
1cmcA-3zyxA:
12.23
1cmcB-3zyxA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 11 LEU A  77
ALA A 429
ALA A 439
VAL A 217
LEU A  71
None
None
FAD  A 600 (-3.5A)
None
None
1.14A 1hbpA-3zyxA:
undetectable
1hbpA-3zyxA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 11 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.93A 1hxwB-3zyxA:
undetectable
1hxwB-3zyxA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 7 GLY A 438
GLN A  65
ILE A  14
VAL A 440
None
FAD  A 600 ( 4.8A)
FAD  A 600 (-4.8A)
None
1.05A 1rxcF-3zyxA:
undetectable
1rxcF-3zyxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 LEU A  22
ALA A 447
LEU A 451
MET A 454
VAL A  30
None
0.98A 1sa1A-3zyxA:
undetectable
1sa1B-3zyxA:
undetectable
1sa1A-3zyxA:
20.70
1sa1B-3zyxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 LEU A  22
ALA A 447
LEU A 451
MET A 454
VAL A  30
None
1.00A 1sa1C-3zyxA:
undetectable
1sa1D-3zyxA:
undetectable
1sa1C-3zyxA:
20.70
1sa1D-3zyxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 11 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.80A 1t7jA-3zyxA:
undetectable
1t7jA-3zyxA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
3 / 3 LEU A 224
HIS A  24
LYS A  21
None
0.95A 1y7iA-3zyxA:
undetectable
1y7iA-3zyxA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 VAL A 189
PHE A 185
THR A 121
LEU A 155
VAL A 169
None
1.22A 2jn3A-3zyxA:
undetectable
2jn3A-3zyxA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.84A 2q64B-3zyxA:
undetectable
2q64B-3zyxA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.87A 2qakA-3zyxA:
undetectable
2qakA-3zyxA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 4 ARG A  67
GLY A 443
GLU A 441
SER A  26
None
1.34A 2xctS-3zyxA:
undetectable
2xctU-3zyxA:
undetectable
2xctS-3zyxA:
21.81
2xctU-3zyxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 4 LEU A 225
ARG A  70
LEU A  75
ALA A  18
None
1.14A 3b9mA-3zyxA:
undetectable
3b9mA-3zyxA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 10 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.85A 3ekpB-3zyxA:
undetectable
3ekpB-3zyxA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 10 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.84A 3ekpC-3zyxA:
undetectable
3ekpC-3zyxA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 10 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.86A 3ekpD-3zyxA:
undetectable
3ekpD-3zyxA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 9 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.85A 3ektA-3zyxA:
undetectable
3ektA-3zyxA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 11 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.84A 3ektC-3zyxA:
undetectable
3ektC-3zyxA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 6 GLY A 438
GLN A  65
ILE A  14
VAL A 440
None
FAD  A 600 ( 4.8A)
FAD  A 600 (-4.8A)
None
1.12A 3kvvA-3zyxA:
undetectable
3kvvA-3zyxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 6 GLY A 438
GLN A  65
ILE A  14
VAL A 440
None
FAD  A 600 ( 4.8A)
FAD  A 600 (-4.8A)
None
1.13A 3kvvB-3zyxA:
undetectable
3kvvB-3zyxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 6 GLY A 438
GLN A  65
ILE A  14
VAL A 440
None
FAD  A 600 ( 4.8A)
FAD  A 600 (-4.8A)
None
1.14A 3kvvC-3zyxA:
undetectable
3kvvC-3zyxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 6 GLY A 438
GLN A  65
ILE A  14
VAL A 440
None
FAD  A 600 ( 4.8A)
FAD  A 600 (-4.8A)
None
1.12A 3kvvD-3zyxA:
undetectable
3kvvD-3zyxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 6 GLY A 438
GLN A  65
ILE A  14
VAL A 440
None
FAD  A 600 ( 4.8A)
FAD  A 600 (-4.8A)
None
1.12A 3kvvE-3zyxA:
undetectable
3kvvE-3zyxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 6 GLY A 438
GLN A  65
ILE A  14
VAL A 440
None
FAD  A 600 ( 4.8A)
FAD  A 600 (-4.8A)
None
1.10A 3kvvF-3zyxA:
undetectable
3kvvF-3zyxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 10 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.78A 3oy4B-3zyxA:
undetectable
3oy4B-3zyxA:
13.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
7 / 8 TYR A  60
LEU A 171
CYH A 172
GLN A 206
PHE A 343
TYR A 398
TYR A 435
FAD  A 600 (-4.4A)
MBT  A 601 (-4.2A)
None
MBT  A 601 (-3.4A)
MBT  A 601 (-4.7A)
MBT  A 601 ( 3.6A)
MBT  A 601 ( 4.6A)
0.19A 3po7A-3zyxA:
65.2
3po7A-3zyxA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PO7_B_ZONB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
8 / 9 TYR A  60
LEU A 171
CYH A 172
ILE A 198
GLN A 206
PHE A 343
TYR A 398
TYR A 435
FAD  A 600 (-4.4A)
MBT  A 601 (-4.2A)
None
None
MBT  A 601 (-3.4A)
MBT  A 601 (-4.7A)
MBT  A 601 ( 3.6A)
MBT  A 601 ( 4.6A)
0.14A 3po7B-3zyxA:
64.8
3po7B-3zyxA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 8 ALA A 442
GLY A 425
THR A 426
ARG A 445
GLU A 427
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
1.38A 3rglA-3zyxA:
undetectable
3rglA-3zyxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 8 GLY A  16
PRO A 265
GLU A 427
ARG A  36
None
FAD  A 600 ( 4.7A)
None
FAD  A 600 (-3.8A)
0.99A 3s3mA-3zyxA:
undetectable
3s3mA-3zyxA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.93A 3so9B-3zyxA:
undetectable
3so9B-3zyxA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 9 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.80A 3spkA-3zyxA:
undetectable
3spkA-3zyxA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.90A 3spkB-3zyxA:
undetectable
3spkB-3zyxA:
11.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
10 / 12 PRO A 104
TRP A 119
LEU A 164
LEU A 171
CYH A 172
GLN A 206
ILE A 316
PHE A 343
TYR A 398
TYR A 435
None
None
None
MBT  A 601 (-4.2A)
None
MBT  A 601 (-3.4A)
MBT  A 601 (-4.6A)
MBT  A 601 (-4.7A)
MBT  A 601 ( 3.6A)
MBT  A 601 ( 4.6A)
0.33A 4a79A-3zyxA:
65.3
4a79A-3zyxA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
10 / 12 PRO A 104
TRP A 119
LEU A 164
LEU A 171
CYH A 172
GLN A 206
ILE A 316
PHE A 343
TYR A 398
TYR A 435
None
None
None
MBT  A 601 (-4.2A)
None
MBT  A 601 (-3.4A)
MBT  A 601 (-4.6A)
MBT  A 601 (-4.7A)
MBT  A 601 ( 3.6A)
MBT  A 601 ( 4.6A)
0.43A 4a79B-3zyxA:
64.7
4a79B-3zyxA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
9 / 11 TYR A  60
LEU A 164
LEU A 171
CYH A 172
GLN A 206
ILE A 316
PHE A 343
TYR A 398
TYR A 435
FAD  A 600 (-4.4A)
None
MBT  A 601 (-4.2A)
None
MBT  A 601 (-3.4A)
MBT  A 601 (-4.6A)
MBT  A 601 (-4.7A)
MBT  A 601 ( 3.6A)
MBT  A 601 ( 4.6A)
0.20A 4a7aA-3zyxA:
65.3
4a7aA-3zyxA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
10 / 12 PRO A 104
LEU A 164
LEU A 167
LEU A 171
CYH A 172
GLN A 206
ILE A 316
PHE A 343
TYR A 398
TYR A 435
None
None
None
MBT  A 601 (-4.2A)
None
MBT  A 601 (-3.4A)
MBT  A 601 (-4.6A)
MBT  A 601 (-4.7A)
MBT  A 601 ( 3.6A)
MBT  A 601 ( 4.6A)
0.42A 4a7aB-3zyxA:
64.9
4a7aB-3zyxA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 6 GLU A 366
LYS A 362
PRO A 380
GLU A 379
None
1.36A 4a7tF-3zyxA:
undetectable
4a7tF-3zyxA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 10 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.81A 4dqbB-3zyxA:
undetectable
4dqbB-3zyxA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 9 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.83A 4dqcB-3zyxA:
undetectable
4dqcB-3zyxA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 10 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.81A 4dqeB-3zyxA:
undetectable
4dqeB-3zyxA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 10 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.81A 4dqhB-3zyxA:
undetectable
4dqhB-3zyxA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 7 GLY A 438
GLN A  65
ILE A  14
VAL A 440
None
FAD  A 600 ( 4.8A)
FAD  A 600 (-4.8A)
None
1.08A 4e1vB-3zyxA:
undetectable
4e1vB-3zyxA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 6 GLY A 438
GLN A  65
ILE A  14
VAL A 440
None
FAD  A 600 ( 4.8A)
FAD  A 600 (-4.8A)
None
1.07A 4e1vF-3zyxA:
undetectable
4e1vF-3zyxA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 10 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.88A 4ll3B-3zyxA:
undetectable
4ll3B-3zyxA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 10 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.82A 4njtB-3zyxA:
undetectable
4njtB-3zyxA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.94A 4njuA-3zyxA:
undetectable
4njuA-3zyxA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.95A 4njuC-3zyxA:
undetectable
4njuC-3zyxA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 VAL A 294
GLY A  57
PHE A 343
GLY A 342
ASP A 330
None
FAD  A 600 ( 3.8A)
MBT  A 601 (-4.7A)
None
None
1.35A 4pevB-3zyxA:
2.5
4pevB-3zyxA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 8 TYR A 300
TRP A 306
GLY A 342
ILE A 344
None
1.00A 4qoiA-3zyxA:
undetectable
4qoiB-3zyxA:
undetectable
4qoiA-3zyxA:
19.21
4qoiB-3zyxA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 ALA A 424
GLY A 425
THR A 426
ALA A 429
THR A 428
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
0.98A 4qvpH-3zyxA:
undetectable
4qvpI-3zyxA:
undetectable
4qvpH-3zyxA:
17.68
4qvpI-3zyxA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 ALA A 424
GLY A 425
THR A 426
ALA A 429
THR A 428
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
0.98A 4qvpV-3zyxA:
undetectable
4qvpW-3zyxA:
undetectable
4qvpV-3zyxA:
17.68
4qvpW-3zyxA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 11 ALA A 424
GLY A 425
THR A 426
ALA A 429
THR A 428
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
0.99A 4qvvH-3zyxA:
undetectable
4qvvH-3zyxA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 11 ALA A 424
GLY A 425
THR A 426
ALA A 429
THR A 428
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
0.99A 4qvvV-3zyxA:
undetectable
4qvvV-3zyxA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 11 ALA A 424
GLY A 425
THR A 426
ALA A 429
THR A 428
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
0.99A 4qvyH-3zyxA:
undetectable
4qvyH-3zyxA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 ALA A 424
GLY A 425
THR A 426
ALA A 429
THR A 428
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
0.99A 4qvyV-3zyxA:
undetectable
4qvyW-3zyxA:
undetectable
4qvyV-3zyxA:
17.68
4qvyW-3zyxA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 11 ALA A 424
GLY A 425
THR A 426
ALA A 429
THR A 428
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
1.00A 4qw0H-3zyxA:
undetectable
4qw0I-3zyxA:
undetectable
4qw0H-3zyxA:
17.68
4qw0I-3zyxA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 11 ALA A 424
GLY A 425
THR A 426
ALA A 429
THR A 428
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
0.99A 4qw0V-3zyxA:
undetectable
4qw0W-3zyxA:
undetectable
4qw0V-3zyxA:
17.68
4qw0W-3zyxA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 ALA A 424
GLY A 425
THR A 426
ALA A 429
THR A 428
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
0.97A 4qw1H-3zyxA:
undetectable
4qw1I-3zyxA:
undetectable
4qw1H-3zyxA:
17.68
4qw1I-3zyxA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 ALA A 424
GLY A 425
THR A 426
ALA A 429
THR A 428
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
0.98A 4qw1V-3zyxA:
undetectable
4qw1W-3zyxA:
undetectable
4qw1V-3zyxA:
17.68
4qw1W-3zyxA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 ASN A  66
GLY A 438
ARG A  70
GLU A 441
GLU A 466
None
1.21A 4xt8A-3zyxA:
undetectable
4xt8A-3zyxA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 7 SER A  26
ARG A  67
GLY A 443
THR A 430
GLU A 441
None
1.48A 5btaA-3zyxA:
undetectable
5btaC-3zyxA:
undetectable
5btaD-3zyxA:
undetectable
5btaA-3zyxA:
22.90
5btaC-3zyxA:
22.90
5btaD-3zyxA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 6 SER A  26
ARG A  67
GLY A 443
THR A 430
GLU A 441
None
1.48A 5btaA-3zyxA:
0.0
5btaB-3zyxA:
undetectable
5btaC-3zyxA:
undetectable
5btaA-3zyxA:
22.90
5btaB-3zyxA:
20.64
5btaC-3zyxA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 6 SER A  26
ARG A  67
GLY A 443
THR A 430
GLU A 441
None
1.47A 5btcA-3zyxA:
0.2
5btcC-3zyxA:
undetectable
5btcD-3zyxA:
undetectable
5btcA-3zyxA:
22.90
5btcC-3zyxA:
22.90
5btcD-3zyxA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 6 SER A  26
ARG A  67
GLY A 443
THR A 430
GLU A 441
None
1.49A 5btcA-3zyxA:
0.2
5btcB-3zyxA:
undetectable
5btcC-3zyxA:
undetectable
5btcA-3zyxA:
22.90
5btcB-3zyxA:
20.64
5btcC-3zyxA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 5 SER A  26
ARG A  67
GLY A 443
THR A 430
None
1.14A 5btiA-3zyxA:
undetectable
5btiB-3zyxA:
undetectable
5btiA-3zyxA:
22.90
5btiB-3zyxA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 5 SER A  26
ARG A  67
GLY A 443
THR A 430
None
1.08A 5btiC-3zyxA:
undetectable
5btiD-3zyxA:
undetectable
5btiC-3zyxA:
22.90
5btiD-3zyxA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 11 ALA A 424
GLY A 425
THR A 426
ALA A 429
THR A 428
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
0.98A 5bxnH-3zyxA:
undetectable
5bxnI-3zyxA:
undetectable
5bxnH-3zyxA:
17.68
5bxnI-3zyxA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 ALA A 424
GLY A 425
THR A 426
ALA A 429
THR A 428
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
0.99A 5cz7V-3zyxA:
undetectable
5cz7W-3zyxA:
undetectable
5cz7V-3zyxA:
17.68
5cz7W-3zyxA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 11 ALA A 424
GLY A 425
THR A 426
ALA A 429
THR A 428
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
0.99A 5d0xV-3zyxA:
undetectable
5d0xV-3zyxA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 9 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.83A 5kr0B-3zyxA:
undetectable
5kr0B-3zyxA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 ALA A 424
GLY A 425
THR A 426
ALA A 429
THR A 428
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
0.99A 5l5fH-3zyxA:
undetectable
5l5fI-3zyxA:
undetectable
5l5fH-3zyxA:
17.68
5l5fI-3zyxA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 ALA A 424
GLY A 425
THR A 426
ALA A 429
THR A 428
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
0.98A 5l5fV-3zyxA:
undetectable
5l5fW-3zyxA:
undetectable
5l5fV-3zyxA:
17.68
5l5fW-3zyxA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 ALA A 424
GLY A 425
THR A 426
ALA A 429
THR A 428
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
0.99A 5l66H-3zyxA:
undetectable
5l66I-3zyxA:
undetectable
5l66H-3zyxA:
17.68
5l66I-3zyxA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 ALA A 424
GLY A 425
THR A 426
ALA A 429
THR A 428
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
0.99A 5l66V-3zyxA:
undetectable
5l66W-3zyxA:
undetectable
5l66V-3zyxA:
17.68
5l66W-3zyxA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 6 GLU A 179
PHE A 402
THR A 400
TYR A 401
None
0.98A 5lrbA-3zyxA:
undetectable
5lrbA-3zyxA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 LEU A 224
ALA A  20
VAL A 229
GLY A  13
ILE A  14
None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-4.8A)
0.83A 5t2zB-3zyxA:
undetectable
5t2zB-3zyxA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 5 GLY A 194
ARG A 197
ASP A 123
MET A 122
None
1.35A 5ubbA-3zyxA:
1.5
5ubbA-3zyxA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 LEU A 414
VAL A 289
PRO A 266
THR A  43
GLY A  41
None
None
None
FAD  A 600 (-4.0A)
FAD  A 600 (-3.2A)
1.25A 5xiqA-3zyxA:
undetectable
5xiqA-3zyxA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 5 PHE A 185
THR A 147
ASP A 153
ASN A 117
None
1.50A 5ybbA-3zyxA:
undetectable
5ybbA-3zyxA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
4 / 7 ALA A 424
GLY A  16
GLY A  11
THR A 428
None
None
FAD  A 600 (-3.1A)
None
0.75A 5ybbB-3zyxA:
undetectable
5ybbB-3zyxA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 11 PHE A 423
ILE A 261
LEU A 414
ILE A 286
MET A 285
None
1.40A 6fgdA-3zyxA:
2.7
6fgdA-3zyxA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 12 ALA A 424
GLY A 425
THR A 426
ALA A 429
THR A 428
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
0.99A 6hwdH-3zyxA:
undetectable
6hwdI-3zyxA:
undetectable
6hwdH-3zyxA:
14.38
6hwdI-3zyxA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo
sapiens)
5 / 11 ALA A 424
GLY A 425
THR A 426
ALA A 429
THR A 428
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
0.99A 6hwdV-3zyxA:
undetectable
6hwdV-3zyxA:
14.38