SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zyy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 4 HIS X 621
LEU X 532
LEU X 525
LEU X 603
 None
 1.15A 1a4lD-3zyyX:
undetectable		 1a4lD-3zyyX:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 9 GLY X 355
ALA X 322
THR X 299
THR X 302
ILE X 308
 None
 1.15A 1gtfD-3zyyX:
undetectable
1gtfE-3zyyX:
undetectable		 1gtfD-3zyyX:
9.44
1gtfE-3zyyX:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 7 TYR X 600
VAL X 247
ILE X 248
GLU X 602
 None
None
None
BU3  X1638 (-3.3A)
 0.75A 1j96B-3zyyX:
undetectable		 1j96B-3zyyX:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 ILE X 450
ASP X 451
LEU X 559
GLY X 448
LEU X 558
 None
 1.01A 1liiA-3zyyX:
undetectable		 1liiA-3zyyX:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 10 SER X 359
GLY X 297
SER X 574
ASP X 212
ILE X 213
 None
None
None
MG  X 802 ( 4.4A)
None
 1.29A 1pw7A-3zyyX:
undetectable		 1pw7A-3zyyX:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 11 GLY X 577
ALA X 578
ILE X 345
GLY X 355
ILE X 357
 None
 0.81A 2aquB-3zyyX:
undetectable		 2aquB-3zyyX:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 GLY X 577
ALA X 578
ILE X 345
GLY X 355
ILE X 357
 None
 0.85A 2avvB-3zyyX:
undetectable		 2avvB-3zyyX:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 11 GLY X 577
ALA X 578
ILE X 345
GLY X 355
ILE X 357
 None
 0.91A 2fxeB-3zyyX:
undetectable		 2fxeB-3zyyX:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 11 ASN X 381
ILE X 213
ASN X 238
ALA X 296
ASP X 245
 PO4  X 801 (-4.5A)
None
None
None
None
 1.44A 2iyfA-3zyyX:
undetectable		 2iyfA-3zyyX:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 10 GLU X 479
ILE X 477
LYS X 467
GLU X 504
ILE X 468
 None
 1.19A 2j9dD-3zyyX:
undetectable
2j9dE-3zyyX:
undetectable
2j9dF-3zyyX:
undetectable		 2j9dD-3zyyX:
12.14
2j9dE-3zyyX:
12.30
2j9dF-3zyyX:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 GLY X 577
ALA X 578
ILE X 345
GLY X 355
ILE X 357
 None
 0.82A 2nmyA-3zyyX:
undetectable		 2nmyA-3zyyX:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 GLY X 577
ALA X 578
ILE X 345
GLY X 355
ILE X 357
 None
 0.87A 2nmzB-3zyyX:
undetectable		 2nmzB-3zyyX:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 11 GLY X 577
ALA X 578
GLY X 355
ILE X 357
VAL X 219
 None
 0.91A 2nnpA-3zyyX:
undetectable		 2nnpA-3zyyX:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 11 GLY X 577
ALA X 578
ILE X 345
GLY X 355
ILE X 357
 None
 0.80A 2nnpA-3zyyX:
undetectable		 2nnpA-3zyyX:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 GLY X 577
ALA X 578
ILE X 345
GLY X 355
ILE X 357
 None
 0.83A 2o4kB-3zyyX:
undetectable		 2o4kB-3zyyX:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 GLY X 577
ALA X 578
ILE X 345
GLY X 355
ILE X 357
 None
 0.88A 2q5kB-3zyyX:
undetectable		 2q5kB-3zyyX:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 GLY X 577
ALA X 578
ILE X 345
GLY X 355
ILE X 357
 None
 0.79A 2q64B-3zyyX:
undetectable		 2q64B-3zyyX:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 GLY X 577
ALA X 578
ILE X 345
GLY X 355
ILE X 357
 None
 0.78A 2qakA-3zyyX:
undetectable		 2qakA-3zyyX:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 7 GLY X 382
MET X 384
PHE X 613
PHE X 609
 None
 0.82A 2qwxA-3zyyX:
undetectable
2qwxB-3zyyX:
undetectable		 2qwxA-3zyyX:
18.89
2qwxB-3zyyX:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 10 ALA X 515
ALA X 519
GLU X 612
ALA X 616
SER X 615
 None
 1.25A 2r2vC-3zyyX:
undetectable
2r2vF-3zyyX:
undetectable
2r2vG-3zyyX:
undetectable		 2r2vC-3zyyX:
5.35
2r2vF-3zyyX:
5.35
2r2vG-3zyyX:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 7 GLY X 360
SER X 573
ALA X 541
ILE X 594
 None
 0.80A 3a2qA-3zyyX:
undetectable		 3a2qA-3zyyX:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 7 VAL X 487
ILE X 461
GLY X 460
ARG X 458
 None
 0.84A 3bjwB-3zyyX:
undetectable		 3bjwB-3zyyX:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 7 VAL X 487
ILE X 461
GLY X 460
ARG X 458
 None
 0.82A 3bjwF-3zyyX:
undetectable		 3bjwF-3zyyX:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 7 VAL X 487
ILE X 461
GLY X 460
ARG X 458
 None
 0.86A 3bjwH-3zyyX:
undetectable		 3bjwH-3zyyX:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 SER X 573
ILE X 378
LEU X 548
ASN X 572
THR X 215
 None
None
None
None
PO4  X 801 (-4.0A)
 1.18A 3dcjA-3zyyX:
2.0
3dcjB-3zyyX:
undetectable		 3dcjA-3zyyX:
17.74
3dcjB-3zyyX:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 GLY X 577
ALA X 578
ILE X 345
GLY X 355
ILE X 357
 None
 0.82A 3ekqA-3zyyX:
undetectable		 3ekqA-3zyyX:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 GLY X 577
ALA X 578
ILE X 345
GLY X 355
ILE X 357
 None
 0.77A 3el1B-3zyyX:
undetectable		 3el1B-3zyyX:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 GLY X 577
ALA X 578
ILE X 345
GLY X 355
ILE X 357
 None
 0.89A 3el4A-3zyyX:
undetectable		 3el4A-3zyyX:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 10 GLY X 577
ALA X 578
ILE X 345
GLY X 355
ILE X 357
 None
 0.82A 3el9B-3zyyX:
undetectable		 3el9B-3zyyX:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 GLY X 379
GLY X 446
GLY X 543
LEU X 452
ILE X 408
 PO4  X 801 ( 4.0A)
None
None
None
None
 1.04A 3eluA-3zyyX:
undetectable		 3eluA-3zyyX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 11 GLN X 240
THR X 302
VAL X 220
LEU X 275
ILE X 211
 None
 1.41A 3elzB-3zyyX:
undetectable		 3elzB-3zyyX:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 GLN X 240
THR X 302
VAL X 220
LEU X 275
ILE X 211
 None
 1.35A 3elzC-3zyyX:
undetectable		 3elzC-3zyyX:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 7 LEU X 269
VAL X 295
LEU X 306
LEU X 195
 None
 0.88A 3g8iA-3zyyX:
undetectable		 3g8iA-3zyyX:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 LEU X 231
GLY X 232
LEU X 222
ALA X 210
LEU X 583
 None
 0.87A 3gwvA-3zyyX:
undetectable		 3gwvA-3zyyX:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 LEU X  27
ASN X  28
GLY X  31
LEU X  95
ILE X 100
 None
 1.13A 3h52A-3zyyX:
undetectable		 3h52A-3zyyX:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 MET X  24
ASN X  28
GLY X  31
LEU X  95
ILE X 100
 FES  X 800 ( 4.7A)
None
None
None
None
 1.25A 3h52A-3zyyX:
undetectable		 3h52A-3zyyX:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 ASP X 482
ALA X 505
GLY X 407
VAL X 501
ILE X 408
 None
 1.11A 3n3iA-3zyyX:
undetectable		 3n3iA-3zyyX:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 11 GLY X 577
ALA X 578
ILE X 345
GLY X 355
ILE X 357
 None
 0.88A 3ndxB-3zyyX:
undetectable		 3ndxB-3zyyX:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 11 PHE X 613
PHE X 609
GLY X 382
MET X 384
ILE X 378
 None
 0.96A 3owxA-3zyyX:
undetectable
3owxB-3zyyX:
undetectable		 3owxA-3zyyX:
18.89
3owxB-3zyyX:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 GLY X 577
ALA X 578
ILE X 345
GLY X 355
ILE X 357
 None
 0.81A 3oxcB-3zyyX:
undetectable		 3oxcB-3zyyX:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		6 / 10 GLY X 297
ALA X 296
ASP X 212
VAL X 294
GLY X 360
VAL X 361
 None
None
MG  X 802 ( 4.4A)
None
None
None
 1.38A 3oxwA-3zyyX:
undetectable		 3oxwA-3zyyX:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 8 GLY X 360
ALA X 541
SER X 573
TYR X 363
 None
 0.77A 3u9hA-3zyyX:
undetectable		 3u9hA-3zyyX:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 8 GLY X 360
ALA X 541
SER X 573
TYR X 363
 None
 0.74A 3u9hB-3zyyX:
undetectable		 3u9hB-3zyyX:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 8 GLY X 360
ALA X 541
SER X 573
TYR X 363
 None
 0.75A 4bjcA-3zyyX:
undetectable		 4bjcA-3zyyX:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 7 LEU X 116
THR X 364
ILE X 539
GLY X 571
 None
 0.90A 4eq4A-3zyyX:
undetectable		 4eq4A-3zyyX:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 7 LEU X 116
THR X 364
ILE X 539
GLY X 571
 None
 0.91A 4eqlA-3zyyX:
undetectable		 4eqlA-3zyyX:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 7 LEU X 116
THR X 364
ILE X 539
GLY X 571
 None
 0.92A 4eqlB-3zyyX:
undetectable		 4eqlB-3zyyX:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 GLY X 382
MET X 384
ILE X 378
PHE X 613
PHE X 609
 None
 0.99A 4fglA-3zyyX:
undetectable
4fglB-3zyyX:
undetectable		 4fglA-3zyyX:
18.89
4fglB-3zyyX:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 7 GLY X 360
ALA X 541
SER X 573
TYR X 363
 None
 0.81A 4hyfA-3zyyX:
undetectable		 4hyfA-3zyyX:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 8 GLY X 360
ALA X 541
SER X 573
TYR X 363
 None
 0.78A 4hyfB-3zyyX:
undetectable		 4hyfB-3zyyX:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 8 GLY X 360
ALA X 541
SER X 573
TYR X 363
 None
 0.80A 4hyfC-3zyyX:
undetectable		 4hyfC-3zyyX:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 ILE X 507
THR X 471
VAL X 472
ILE X 461
GLU X 426
 None
 1.19A 4i41A-3zyyX:
undetectable		 4i41A-3zyyX:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 7 LEU X 116
THR X 364
ILE X 539
GLY X 571
 None
 0.90A 4l39B-3zyyX:
undetectable		 4l39B-3zyyX:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 9 MET X 346
SER X 359
ARG X 579
LEU X 582
ALA X 210
 None
 1.49A 4rkuB-3zyyX:
0.9		 4rkuB-3zyyX:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 11 GLN X  97
GLY X 360
ALA X 541
SER X 573
TYR X 363
 None
 1.50A 4rv6A-3zyyX:
undetectable		 4rv6A-3zyyX:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 11 GLN X  99
GLY X 360
ALA X 541
SER X 573
TYR X 363
 None
 1.28A 4rv6A-3zyyX:
undetectable		 4rv6A-3zyyX:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 11 GLN X  97
GLY X 360
ALA X 541
SER X 573
TYR X 363
 None
 1.48A 4rv6B-3zyyX:
undetectable		 4rv6B-3zyyX:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 11 GLN X  99
GLY X 360
ALA X 541
SER X 573
TYR X 363
 None
 1.27A 4rv6B-3zyyX:
undetectable		 4rv6B-3zyyX:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 9 MET X 346
SER X 359
ARG X 579
LEU X 582
ALA X 210
 None
 1.46A 4y28B-3zyyX:
0.9		 4y28B-3zyyX:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 5 PHE X 375
GLY X 577
ASP X 377
ILE X 357
 None
None
MG  X 802 ( 4.0A)
None
 0.84A 5ik1A-3zyyX:
undetectable		 5ik1A-3zyyX:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 5 GLY X 354
THR X 299
GLY X 228
LEU X 575
 None
 0.89A 5jlcA-3zyyX:
undetectable		 5jlcA-3zyyX:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 7 GLY X 577
ALA X 578
GLY X 355
ILE X 357
 None
 0.62A 5kqyB-3zyyX:
undetectable		 5kqyB-3zyyX:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 8 GLY X 577
ALA X 578
GLY X 355
ILE X 357
 None
 0.62A 5kr1B-3zyyX:
undetectable		 5kr1B-3zyyX:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 ALA X 296
SER X 359
VAL X 294
ILE X 345
PRO X 347
 None
 1.44A 5mlmA-3zyyX:
undetectable		 5mlmA-3zyyX:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 9 ASP X 212
ILE X 357
GLY X 542
SER X 574
GLY X 360
 MG  X 802 ( 4.4A)
None
None
None
None
 1.35A 6awoA-3zyyX:
undetectable		 6awoA-3zyyX:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 9 ASP X 212
ILE X 357
GLY X 542
SER X 574
GLY X 360
 MG  X 802 ( 4.4A)
None
None
None
None
 1.35A 6awqA-3zyyX:
undetectable		 6awqA-3zyyX:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		6 / 10 GLY X  62
LEU X  64
THR X  79
VAL X  49
VAL X  58
LEU X  48
 None
 1.40A 6czmA-3zyyX:
undetectable
6czmC-3zyyX:
undetectable		 6czmA-3zyyX:
21.98
6czmC-3zyyX:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		6 / 9 VAL X  49
VAL X  58
LEU X  48
GLY X  62
LEU X  64
THR X  79
 None
 1.39A 6czmA-3zyyX:
undetectable
6czmB-3zyyX:
undetectable		 6czmA-3zyyX:
21.98
6czmB-3zyyX:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		6 / 9 VAL X  49
VAL X  58
LEU X  48
GLY X  62
LEU X  64
THR X  79
 None
 1.41A 6czmB-3zyyX:
undetectable
6czmC-3zyyX:
undetectable		 6czmB-3zyyX:
21.98
6czmC-3zyyX:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		6 / 9 VAL X  49
VAL X  58
LEU X  48
GLY X  62
LEU X  64
THR X  79
 None
 1.38A 6czmD-3zyyX:
undetectable
6czmE-3zyyX:
undetectable		 6czmD-3zyyX:
21.98
6czmE-3zyyX:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 10 VAL X  49
VAL X  58
GLY X  62
LEU X  64
THR X  79
 None
 1.30A 6czmE-3zyyX:
undetectable
6czmF-3zyyX:
undetectable		 6czmE-3zyyX:
21.98
6czmF-3zyyX:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 10 VAL X  49
VAL X  58
LEU X  48
GLY X  62
LEU X  64
 None
 1.15A 6czmE-3zyyX:
undetectable
6czmF-3zyyX:
undetectable		 6czmE-3zyyX:
21.98
6czmF-3zyyX:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		3 / 3 LYS X 198
SER X 180
SER X 201
 None
 1.15A 6gbfA-3zyyX:
undetectable		 6gbfA-3zyyX:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 9 MET X 346
SER X 359
ARG X 579
LEU X 582
ALA X 210
 None
 1.47A 6hqbB-3zyyX:
undetectable		 6hqbB-3zyyX:
9.06