SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zzf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_A_STRA1_1
(PROGESTERONE
RECEPTOR)		 3zzf ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 247
LEU A 210
GLN A 244
LEU A 173
THR A 136
 NLG  A1360 (-2.8A)
None
None
None
NLG  A1360 (-4.9A)
 1.45A 1a28A-3zzfA:
undetectable		 1a28A-3zzfA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 3zzf ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 338
TYR A  87
PHE A 122
LEU A 123
 None
None
None
HG  A1358 ( 4.5A)
 0.89A 3i45A-3zzfA:
2.7		 3i45A-3zzfA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3zzf ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 105
GLY A 106
PRO A 130
VAL A 188
LEU A 231
 EDO  A1355 ( 4.5A)
NLG  A1360 ( 4.9A)
None
None
None
 1.00A 3m6wA-3zzfA:
2.9		 3m6wA-3zzfA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 3zzf ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 7 PRO A 138
LEU A 113
GLY A 105
ALA A 107
 None
None
EDO  A1355 ( 4.5A)
None
 0.98A 3tehB-3zzfA:
undetectable		 3tehB-3zzfA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3zzf ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 337
TYR A  90
LEU A 128
PHE A 339
 EDO  A1354 (-3.0A)
None
None
None
 0.95A 4twdF-3zzfA:
undetectable
4twdJ-3zzfA:
undetectable		 4twdF-3zzfA:
19.94
4twdJ-3zzfA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3zzf ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 120
TYR A 124
PRO A 130
LEU A 183
 None
 0.99A 4z4fA-3zzfA:
undetectable		 4z4fA-3zzfA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3zzf ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 255
ILE A 313
LEU A 317
ILE A 266
GLY A 135
 None
None
None
EDO  A1354 (-4.7A)
NLG  A1360 (-3.2A)
 0.97A 5d4uC-3zzfA:
undetectable		 5d4uC-3zzfA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3zzf ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 255
ILE A 313
LEU A 317
ILE A 266
GLY A 135
 None
None
None
EDO  A1354 (-4.7A)
NLG  A1360 (-3.2A)
 0.95A 5d4uD-3zzfA:
undetectable		 5d4uD-3zzfA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3zzf ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 120
TYR A 124
PRO A 130
LEU A 183
 None
 0.87A 5t7bA-3zzfA:
3.5		 5t7bA-3zzfA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 3zzf ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 237
ALA A 250
ASP A 251
GLY A 106
ILE A 109
VAL A 168
 None
NLG  A1360 (-3.3A)
None
NLG  A1360 ( 4.9A)
None
None
 1.48A 6dilA-3zzfA:
undetectable		 6dilA-3zzfA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 3zzf ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 193
THR A 194
PRO A 221
 None
 0.49A 6ncsA-3zzfA:
undetectable		 6ncsA-3zzfA:
21.24