SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zzi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_A_STRA1_1
(PROGESTERONE
RECEPTOR)		 3zzi ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 247
LEU A 210
GLN A 244
LEU A 173
THR A 136
 None
 1.41A 1a28A-3zziA:
undetectable		 1a28A-3zziA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 3zzi ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 7 THR A  70
SER A  69
HIS A 125
TYR A 129
LEU A 231
 None
 1.43A 1ibgL-3zziA:
undetectable		 1ibgL-3zziA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 3zzi ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 269
LEU A 133
VAL A 132
ILE A 233
LEU A 113
 None
 1.01A 1s19A-3zziA:
undetectable		 1s19A-3zziA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 3zzi ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 389
VAL A 425
GLU A 384
ASP A 376
 None
 1.22A 1s3zA-3zziA:
10.9
1s3zB-3zziA:
11.2		 1s3zA-3zziA:
16.78
1s3zB-3zziA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 3zzi ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 247
LEU A 210
GLN A 244
LEU A 173
THR A 136
 None
 1.17A 2aa6B-3zziA:
undetectable		 2aa6B-3zziA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 3zzi ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 179
VAL A 188
GLY A 187
ALA A 190
LEU A 231
 None
 1.21A 2bxgA-3zziA:
undetectable		 2bxgA-3zziA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 3zzi ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 393
SER A 396
ASP A 397
ASP A 415
 None
 1.19A 2j2pE-3zziA:
undetectable
2j2pF-3zziA:
undetectable		 2j2pE-3zziA:
19.47
2j2pF-3zziA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3zzi ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 334
LEU A 338
ILE A 108
SER A 325
VAL A 132
 None
 1.09A 2po7A-3zziA:
2.2		 2po7A-3zziA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 3zzi ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  88
ASP A 437
LYS A  89
GLU A  85
 None
 1.13A 2vn1B-3zziA:
undetectable		 2vn1B-3zziA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 3zzi ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 191
GLU A 184
TYR A 124
 None
 0.87A 3k37B-3zziA:
undetectable		 3k37B-3zziA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 3zzi ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A  99
TYR A  87
LEU A 123
PHE A 122
 None
 0.88A 4qopC-3zziA:
undetectable		 4qopC-3zziA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3zzi ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 120
TYR A 124
PRO A 130
LEU A 183
 None
 1.04A 4z4fA-3zziA:
3.4		 4z4fA-3zziA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3zzi ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 9 TYR A 352
GLY A 351
VAL A 435
ASP A 341
ASN A 433
 None
 1.36A 5f8yB-3zziA:
undetectable		 5f8yB-3zziA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3zzi ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 120
TYR A 124
PRO A 130
LEU A 183
 None
 0.91A 5t7bA-3zziA:
3.4		 5t7bA-3zziA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3zzi ACETYLGLUTAMATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 299
LEU A 296
SER A 285
ILE A 284
THR A 280
 None
 1.24A 6debB-3zziA:
2.1		 6debB-3zziA:
10.91