SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2
(Homo
sapiens) 		4 / 6 VAL A 681
ILE A 742
ILE A 599
ASP A 674
 None
 0.73A 1uwhA-3zzwA:
27.6		 1uwhA-3zzwA:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2
(Homo
sapiens) 		4 / 8 THR A 618
VAL A 621
VAL A 623
ASN A 628
 None
 1.15A 2ij7C-3zzwA:
undetectable		 2ij7C-3zzwA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2
(Homo
sapiens) 		5 / 10 LEU A 682
LEU A 565
LEU A 595
VAL A 596
PHE A 686
 None
 0.99A 2w9gA-3zzwA:
undetectable		 2w9gA-3zzwA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2
(Homo
sapiens) 		5 / 10 LEU A 682
LEU A 565
LEU A 595
VAL A 596
PHE A 686
 None
 1.03A 2w9hA-3zzwA:
undetectable		 2w9hA-3zzwA:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2
(Homo
sapiens) 		4 / 6 LEU A 479
LYS A 507
LEU A 622
ASP A 633
 None
 0.79A 3cs9D-3zzwA:
28.0		 3cs9D-3zzwA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2
(Homo
sapiens) 		4 / 6 LEU A 479
VAL A 487
LYS A 507
ASP A 633
 None
 0.89A 3cs9D-3zzwA:
28.0		 3cs9D-3zzwA:
35.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2
(Homo
sapiens) 		5 / 11 LEU A 682
LEU A 565
LEU A 595
VAL A 596
PHE A 686
 None
 0.96A 3frbX-3zzwA:
undetectable		 3frbX-3zzwA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2
(Homo
sapiens) 		5 / 9 LEU A 587
LEU A 627
ILE A 599
PHE A 592
VAL A 685
 None
CL  A1751 (-4.6A)
None
None
None
 0.89A 3tmzA-3zzwA:
undetectable		 3tmzA-3zzwA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2
(Homo
sapiens) 		4 / 8 VAL A 536
VAL A 537
LEU A 622
ILE A 631
 None
 0.43A 3wzeA-3zzwA:
31.7		 3wzeA-3zzwA:
35.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2
(Homo
sapiens) 		4 / 8 ARG A 483
GLU A 520
GLU A 524
ARG A 528
 None
 1.05A 4bqfB-3zzwA:
undetectable		 4bqfB-3zzwA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2
(Homo
sapiens) 		4 / 6 GLY A 689
ASP A 615
ILE A 656
ARG A 657
 None
 0.99A 5iwuA-3zzwA:
6.4		 5iwuA-3zzwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2
(Homo
sapiens) 		5 / 10 PRO A 655
ILE A 675
ARG A 736
PRO A 733
VAL A 612
 None
 1.11A 5m0oA-3zzwA:
undetectable		 5m0oA-3zzwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2
(Homo
sapiens) 		5 / 12 LEU A 479
GLY A 480
VAL A 487
ALA A 505
PHE A 553
 None
 0.59A 5xv7A-3zzwA:
19.4		 5xv7A-3zzwA:
14.45