SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '487d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 487d PROTEIN (50S L2
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		5 / 11 LEU I 153
ALA I 161
ILE I 134
ILE I 172
ILE I 143
 None
 0.95A 1c6yA-487dI:
undetectable		 1c6yA-487dI:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 487d PROTEIN (50S L14
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		5 / 9 VAL M  69
GLY M  68
THR M  65
VAL M  62
ASP M  37
 None
 1.27A 1dz8A-487dM:
undetectable		 1dz8A-487dM:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 487d PROTEIN (50S L2
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		5 / 9 GLY I 112
ILE I 103
GLY I 126
ILE I 125
ILE I  80
 None
 0.86A 1hpvA-487dI:
undetectable		 1hpvA-487dI:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 487d PROTEIN (50S L14
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		5 / 10 SER M  14
VAL M  52
ALA M  16
CYH M  84
VAL M  19
 None
 1.27A 1td2A-487dM:
undetectable		 1td2A-487dM:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 487d PROTEIN (50S L2
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		5 / 10 ILE I 123
ALA I 128
LEU I 131
ILE I 134
SER I 160
 None
 1.10A 2w9sD-487dI:
undetectable		 2w9sD-487dI:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 487d PROTEIN (50S L2
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		5 / 10 ILE I 123
ALA I 128
LEU I 131
ILE I 134
SER I 160
 None
 1.11A 2w9sF-487dI:
undetectable		 2w9sF-487dI:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 487d PROTEIN (50S L9
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		5 / 10 ILE K 121
THR K 127
VAL K 145
ILE K  98
SER K  95
 None
 1.33A 3kpbD-487dK:
undetectable		 3kpbD-487dK:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 487d PROTEIN (50S L9
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		5 / 11 ILE K 121
THR K 127
VAL K 145
ILE K  98
SER K  95
 None
 1.25A 3kpcA-487dK:
undetectable		 3kpcA-487dK:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 487d PROTEIN (50S L9
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		6 / 12 ILE K 121
THR K 127
VAL K 145
ILE K  79
ILE K  98
SER K  95
 None
 1.36A 3kpdB-487dK:
undetectable		 3kpdB-487dK:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 487d PROTEIN (50S L9
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		6 / 12 ILE K 121
THR K 127
VAL K 145
ILE K  79
ILE K  98
SER K  95
 None
 1.25A 3kpdC-487dK:
undetectable		 3kpdC-487dK:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 487d PROTEIN (50S L2
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		5 / 12 LEU I 153
ALA I 161
ILE I 134
ILE I 172
ILE I 143
 None
 0.92A 3oxcB-487dI:
undetectable		 3oxcB-487dI:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 487d PROTEIN (50S L6
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		5 / 12 ILE J 161
VAL J 106
LEU J 104
ILE J 114
LEU J 143
 None
 1.07A 3w67D-487dJ:
undetectable		 3w67D-487dJ:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 487d PROTEIN (50S L6
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		4 / 8 HIS J  60
PRO J  54
ALA J  62
ASP J  39
 None
 1.06A 4k0bB-487dJ:
undetectable		 4k0bB-487dJ:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 487d PROTEIN (50S L2
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		5 / 11 LEU I 153
ALA I 161
ILE I 134
ILE I 172
ILE I 143
 None
 0.94A 4qgiB-487dI:
undetectable		 4qgiB-487dI:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 487d PROTEIN (50S L9
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		5 / 12 LEU K 141
ALA K 139
LEU K  68
LEU K 133
HIS K 106
 None
 1.17A 4zn7A-487dK:
undetectable		 4zn7A-487dK:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 487d PROTEIN (50S L9
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		5 / 11 LEU K 141
ALA K 139
LEU K  68
LEU K 133
HIS K 106
 None
 1.17A 4zn7B-487dK:
undetectable		 4zn7B-487dK:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 487d PROTEIN (50S L9
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		4 / 8 ILE K  98
LEU K 102
ILE K 115
LEU K 110
 None
 0.79A 4zvcA-487dK:
undetectable
4zvcB-487dK:
undetectable		 4zvcA-487dK:
19.89
4zvcB-487dK:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 487d PROTEIN (50S L9
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		4 / 8 ILE K 115
LEU K 110
ILE K  98
LEU K 102
 None
 0.79A 4zvcA-487dK:
undetectable
4zvcB-487dK:
undetectable		 4zvcA-487dK:
19.89
4zvcB-487dK:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 487d PROTEIN (50S L14
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		5 / 10 GLY M  36
ALA M  83
VAL M  62
ASP M 108
ILE M  35
 None
 1.23A 5i3cB-487dM:
undetectable		 5i3cB-487dM:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 487d PROTEIN (50S L6
RIBOSOMAL PROTEIN)
(Geobacillus
stearothermophil
us) 		4 / 4 ASP J  39
HIS J  60
HIS J  59
HIS J  37
 None
 1.27A 5ncdD-487dJ:
undetectable		 5ncdD-487dJ:
23.11