SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 4a04 T-BOX TRANSCRIPTION
FACTOR TBX1
(Homo
sapiens) 		5 / 10 ASP A 121
GLU A 122
ALA A 287
PRO A 290
ALA A 292
 None
 1.41A 1mskA-4a04A:
undetectable		 1mskA-4a04A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 4a04 T-BOX TRANSCRIPTION
FACTOR TBX1
(Homo
sapiens) 		3 / 3 LYS A 134
ASP A 224
ILE A 131
 None
 0.83A 5kc4E-4a04A:
undetectable		 5kc4E-4a04A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 4a04 T-BOX TRANSCRIPTION
FACTOR TBX1
(Homo
sapiens) 		3 / 3 TYR A 245
ASP A 155
ASP A 151
 None
 0.86A 5x6yA-4a04A:
undetectable		 5x6yA-4a04A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 4a04 T-BOX TRANSCRIPTION
FACTOR TBX1
(Homo
sapiens) 		5 / 11 ASP A 121
GLU A 122
ALA A 287
PRO A 290
ALA A 292
 None
 1.46A 6bm5A-4a04A:
undetectable		 6bm5A-4a04A:
18.29