SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		4 / 8 PHE A 314
GLY A 329
VAL A 379
PHE A 364
 None
 1.05A 1gsfA-4a05A:
1.3		 1gsfA-4a05A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		4 / 8 PHE A 314
GLY A 329
VAL A 379
PHE A 364
 None
 1.05A 1gsfB-4a05A:
1.2		 1gsfB-4a05A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		4 / 8 PHE A 314
GLY A 329
VAL A 379
PHE A 364
 None
 1.05A 1gsfD-4a05A:
1.3		 1gsfD-4a05A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		4 / 7 LEU A 281
LEU A 254
LEU A 330
GLY A 329
 None
 0.88A 1n13D-4a05A:
undetectable
1n13E-4a05A:
undetectable		 1n13D-4a05A:
13.46
1n13E-4a05A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		3 / 3 VAL A 327
ALA A 326
HIS A 288
 None
 0.78A 1q23C-4a05A:
undetectable		 1q23C-4a05A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		3 / 3 VAL A 327
ALA A 326
HIS A 288
 None
 0.75A 1q23H-4a05A:
undetectable		 1q23H-4a05A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		3 / 3 VAL A 327
ALA A 326
HIS A 288
 None
 0.74A 1q23G-4a05A:
undetectable		 1q23G-4a05A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		3 / 3 VAL A 327
ALA A 326
HIS A 288
 None
 0.68A 1q23J-4a05A:
undetectable		 1q23J-4a05A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		5 / 12 TYR A 348
ASP A 431
ASN A 333
HIS A 297
ILE A 342
 None
None
None
CTT  A 503 (-4.1A)
None
 1.34A 1xvaB-4a05A:
undetectable		 1xvaB-4a05A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		5 / 11 ASN A 129
ILE A 196
GLY A 195
THR A 245
LEU A 164
 None
 1.06A 1z11A-4a05A:
undetectable		 1z11A-4a05A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		5 / 11 ASN A 129
ILE A 196
GLY A 195
THR A 245
LEU A 164
 None
 1.06A 1z11B-4a05A:
undetectable		 1z11B-4a05A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		5 / 10 ASN A 129
ILE A 196
GLY A 195
THR A 245
LEU A 164
 None
 1.00A 1z11C-4a05A:
undetectable		 1z11C-4a05A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		5 / 10 ASN A 129
ILE A 196
GLY A 195
THR A 245
LEU A 164
 None
 1.07A 1z11D-4a05A:
undetectable		 1z11D-4a05A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		4 / 6 ASP A 165
TYR A 200
PHE A 174
LEU A 247
 CBI  A 502 (-3.0A)
None
None
None
 1.04A 2w98A-4a05A:
undetectable
2w98B-4a05A:
undetectable		 2w98A-4a05A:
20.79
2w98B-4a05A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		4 / 6 GLN A 467
ALA A 450
THR A 452
PHE A 461
 None
 1.04A 2xfhA-4a05A:
undetectable		 2xfhA-4a05A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		5 / 12 THR A 332
GLY A 296
GLY A 329
ASN A 333
LEU A 301
 None
 1.17A 3eeyD-4a05A:
undetectable		 3eeyD-4a05A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		5 / 12 LEU A 469
GLY A 428
GLY A 427
PRO A 426
ALA A 140
 None
None
None
CBI  A 502 (-4.3A)
None
 1.22A 3i5uA-4a05A:
undetectable		 3i5uA-4a05A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		5 / 12 LEU A 469
GLY A 428
GLY A 427
PRO A 426
ALA A 140
 None
None
None
CBI  A 502 (-4.3A)
None
 1.21A 3i5uB-4a05A:
undetectable		 3i5uB-4a05A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		5 / 11 ILE A 233
ASP A 171
PHE A 174
ILE A 243
LEU A 237
 None
NAG  A 500 (-3.6A)
None
None
None
 1.12A 3qg2B-4a05A:
undetectable		 3qg2B-4a05A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		4 / 5 ASN A 185
ALA A 189
PRO A 192
ALA A 194
 None
 1.09A 3twpD-4a05A:
undetectable		 3twpD-4a05A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		5 / 10 ALA A 331
ILE A 378
PRO A 120
LEU A 126
ILE A 246
 None
 1.24A 4dtaA-4a05A:
undetectable		 4dtaA-4a05A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		4 / 7 GLY A 427
GLY A 428
TYR A 464
ASN A 399
 None
 1.04A 4fgkB-4a05A:
undetectable		 4fgkB-4a05A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		4 / 7 LEU A 469
ALA A 150
LEU A 148
SER A 145
 None
 1.09A 4iklA-4a05A:
undetectable
4iklB-4a05A:
undetectable		 4iklA-4a05A:
14.48
4iklB-4a05A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		3 / 3 TYR A 279
ARG A 228
LYS A 227
 None
 1.44A 4wq5B-4a05A:
undetectable		 4wq5B-4a05A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4a05 CELLOBIOHYDROLASE
FAMILY 6
(Chaetomium
thermophilum) 		5 / 12 GLU A 250
ASP A 294
LEU A 330
ALA A 310
ASP A 206
 None
None
None
None
CTT  A 503 (-3.1A)
 1.08A 4xe5A-4a05A:
undetectable		 4xe5A-4a05A:
16.67