SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a0h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 6 VAL A 193
GLY A 192
ALA A 231
LEU A 235
 None
 0.78A 1e7bB-4a0hA:
undetectable		 1e7bB-4a0hA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 5 GLU A 129
LEU A  52
LEU A 131
LEU A  51
 None
 1.12A 1np1A-4a0hA:
undetectable		 1np1A-4a0hA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		5 / 12 SER A 109
ILE A  57
THR A 154
ALA A 153
VAL A  91
 None
 1.48A 2gl0D-4a0hA:
undetectable
2gl0E-4a0hA:
undetectable		 2gl0D-4a0hA:
13.09
2gl0E-4a0hA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		3 / 3 SER A 680
TYR A 681
HIS A 679
 None
 0.79A 2r2vD-4a0hA:
undetectable		 2r2vD-4a0hA:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 8 SER A 349
PRO A 374
LEU A 382
THR A 338
 None
 1.15A 2v0zO-4a0hA:
undetectable		 2v0zO-4a0hA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		5 / 9 ILE A 772
GLY A 771
LEU A 764
SER A 762
GLU A 769
 None
 1.13A 3ai9X-4a0hA:
undetectable		 3ai9X-4a0hA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 8 LEU A 764
ILE A 781
PHE A 742
ARG A 804
 None
 0.95A 3b9lA-4a0hA:
2.8		 3b9lA-4a0hA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 4 LEU A 801
ARG A 734
LEU A 746
ALA A 743
 None
 1.05A 3b9mA-4a0hA:
2.5		 3b9mA-4a0hA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 5 ILE A 142
SER A 143
PRO A 144
PRO A 196
 None
 1.39A 3bjwC-4a0hA:
undetectable		 3bjwC-4a0hA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		5 / 12 CYH A 688
ALA A 691
ALA A 692
LEU A 412
LEU A 646
 None
 0.95A 3fc6C-4a0hA:
undetectable		 3fc6C-4a0hA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		5 / 11 GLY A 771
PHE A 773
ALA A 365
ASP A 770
ILE A 772
 None
 1.29A 3id5B-4a0hA:
undetectable		 3id5B-4a0hA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		5 / 11 GLY A 771
PHE A 773
ALA A 365
ASP A 770
ILE A 772
 None
 1.29A 3id5F-4a0hA:
undetectable		 3id5F-4a0hA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 7 TYR A 802
LEU A 767
PHE A 742
VAL A 737
 None
 1.09A 3jwqC-4a0hA:
undetectable		 3jwqC-4a0hA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 7 GLU A 745
VAL A 732
VAL A 736
ALA A 743
 None
 1.04A 3kp6B-4a0hA:
undetectable		 3kp6B-4a0hA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		3 / 3 ASP A 429
ASN A 430
SER A 680
 None
PLP  A1644 (-3.6A)
None
 0.86A 3lslA-4a0hA:
undetectable
3lslD-4a0hA:
0.7		 3lslA-4a0hA:
16.94
3lslD-4a0hA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		3 / 3 SER A 680
ASP A 429
ASN A 430
 None
None
PLP  A1644 (-3.6A)
 0.78A 3lslA-4a0hA:
undetectable
3lslD-4a0hA:
0.7		 3lslA-4a0hA:
16.94
3lslD-4a0hA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		3 / 3 GLN A 494
THR A 490
LEU A 777
 None
 0.65A 3ondA-4a0hA:
2.1		 3ondA-4a0hA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		3 / 3 GLN A 494
THR A 490
LEU A 777
 None
 0.64A 3ondB-4a0hA:
undetectable		 3ondB-4a0hA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		5 / 6 SER A 556
TYR A 555
ALA A 557
ARG A 553
LEU A 596
 None
 1.43A 3ravA-4a0hA:
undetectable		 3ravA-4a0hA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 7 ASP A 429
SER A 682
TYR A 426
HIS A 677
 None
 1.35A 4arcA-4a0hA:
undetectable		 4arcA-4a0hA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 7 THR A 154
ALA A 148
LEU A 146
SER A 143
 None
 0.97A 4d7bA-4a0hA:
undetectable		 4d7bA-4a0hA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 7 PHE A 286
VAL A 274
GLY A  27
PHE A 293
 None
 0.99A 4ejjB-4a0hA:
undetectable		 4ejjB-4a0hA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 6 GLY A 588
GLY A 589
GLU A 581
ILE A 584
 None
None
PLP  A1644 (-3.6A)
None
 0.92A 4fglD-4a0hA:
4.1		 4fglD-4a0hA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 8 MET A 441
ALA A 442
PHE A 614
PHE A 642
 None
 1.01A 4ltwA-4a0hA:
undetectable		 4ltwA-4a0hA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 8 VAL A 780
VAL A 736
TYR A 782
TRP A 370
 None
None
None
KAP  A1808 ( 4.8A)
 1.08A 4pwdC-4a0hA:
2.9		 4pwdC-4a0hA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		5 / 12 LEU A 271
LYS A 294
LEU A 296
ALA A 244
ILE A 215
 None
 1.10A 4x1iD-4a0hA:
3.9		 4x1iD-4a0hA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		5 / 12 LEU A 646
GLY A 431
ALA A 434
THR A 656
VAL A 425
 None
PLP  A1644 (-3.0A)
None
None
None
 1.01A 4xdrA-4a0hA:
undetectable		 4xdrA-4a0hA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 7 VAL A 593
GLN A 598
LEU A 469
SER A 472
 None
 0.92A 4zphA-4a0hA:
undetectable
4zphB-4a0hA:
undetectable		 4zphA-4a0hA:
18.68
4zphB-4a0hA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 6 ALA A 485
SER A 487
ASP A 506
PRO A 507
 None
 1.12A 5c6pA-4a0hA:
undetectable		 5c6pA-4a0hA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 8 ILE A 772
GLY A 771
CYH A 366
ASN A 347
 None
 0.95A 5hieD-4a0hA:
undetectable		 5hieD-4a0hA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		3 / 3 ARG A 796
PRO A   7
ASN A 347
 None
 0.97A 5jwaA-4a0hA:
undetectable
5jwaH-4a0hA:
undetectable		 5jwaA-4a0hA:
20.74
5jwaH-4a0hA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 7 LEU A 102
ILE A  57
THR A 134
TRP A 138
 None
 1.19A 5ljcA-4a0hA:
undetectable		 5ljcA-4a0hA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		5 / 12 VAL A 274
PHE A 293
PHE A 286
LEU A 296
VAL A 292
 None
 1.34A 6a93B-4a0hA:
undetectable		 6a93B-4a0hA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		5 / 11 THR A 477
SER A 428
ALA A 654
THR A 656
ALA A 442
 None
 1.08A 6efnA-4a0hA:
2.6		 6efnA-4a0hA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		3 / 3 LEU A  40
SER A  38
PHE A  39
 None
 0.66A 6fgcA-4a0hA:
undetectable		 6fgcA-4a0hA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 8 SER A 143
GLY A 112
SER A 109
VAL A 155
 None
 1.07A 6giqL-4a0hA:
undetectable
6giqP-4a0hA:
undetectable
6giqT-4a0hA:
undetectable		 6giqL-4a0hA:
20.21
6giqP-4a0hA:
14.39
6giqT-4a0hA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Arabidopsis
thaliana) 		5 / 12 ARG A 599
VAL A 510
ILE A 519
ILE A 554
ILE A 580
 None
 1.14A 6mkeB-4a0hA:
undetectable
6mkeC-4a0hA:
undetectable		 6mkeB-4a0hA:
7.85
6mkeC-4a0hA:
7.85