SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 4a0k DNA DAMAGE-BINDING
PROTEIN 2
(Danio
rerio) 		4 / 8 ASP D 407
VAL D 389
HIS D 366
GLY D 391
 None
 0.91A 1ekjA-4a0kD:
undetectable
1ekjB-4a0kD:
undetectable		 1ekjA-4a0kD:
20.45
1ekjB-4a0kD:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 4a0k CULLIN-4A
(Homo
sapiens) 		4 / 5 LEU A 299
GLU A 297
ALA A 301
LEU A 303
 None
 1.17A 1eta1-4a0kA:
undetectable		 1eta1-4a0kA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 4a0k CULLIN-4A
(Homo
sapiens) 		4 / 6 LEU A 299
GLU A 297
ALA A 301
LEU A 303
 None
 1.18A 1etb1-4a0kA:
undetectable		 1etb1-4a0kA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 4a0k CULLIN-4A
(Homo
sapiens) 		3 / 3 ALA A 320
VAL A 375
TRP A 340
 None
 0.93A 1gmkC-4a0kA:
undetectable
1gmkD-4a0kA:
undetectable		 1gmkC-4a0kA:
6.47
1gmkD-4a0kA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4a0k CULLIN-4A
(Homo
sapiens) 		4 / 7 LEU A 126
SER A 128
PHE A 131
LEU A 132
 None
 0.83A 1j8uA-4a0kA:
undetectable		 1j8uA-4a0kA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 4a0k CULLIN-4A
(Homo
sapiens) 		4 / 8 PHE A 449
HIS A 412
LEU A 366
MET A 361
 None
 1.15A 1x8vA-4a0kA:
3.5		 1x8vA-4a0kA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 4a0k DNA DAMAGE-BINDING
PROTEIN 2
(Danio
rerio) 		4 / 8 GLY D 197
THR D 375
ILE D 195
SER D 152
 None
 0.85A 2a8tB-4a0kD:
undetectable		 2a8tB-4a0kD:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 4a0k DNA DAMAGE-BINDING
PROTEIN 2
(Danio
rerio) 		3 / 3 ASP D 147
THR D 375
PRO D 376
 None
 0.71A 2qakB-4a0kD:
undetectable		 2qakB-4a0kD:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 4a0k CULLIN-4A
(Homo
sapiens) 		4 / 6 ARG A 742
ASP A 697
ILE A 696
GLN A 722
 None
 1.26A 2ya7C-4a0kA:
undetectable		 2ya7C-4a0kA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 4a0k CULLIN-4A
(Homo
sapiens) 		3 / 3 MET A 498
GLU A 472
ASP A 414
 None
 0.93A 3a25A-4a0kA:
undetectable		 3a25A-4a0kA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 4a0k CULLIN-4A
(Homo
sapiens) 		5 / 12 MET A 704
LEU A 710
ASN A 751
ILE A 736
VAL A 727
 None
 1.35A 3a51B-4a0kA:
2.3		 3a51B-4a0kA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4a0k CULLIN-4A
(Homo
sapiens) 		4 / 5 ASP A 434
THR A 432
LEU A 433
LYS A 478
 None
 1.24A 4a3pA-4a0kA:
undetectable		 4a3pA-4a0kA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 4a0k CULLIN-4A
E3 UBIQUITIN-PROTEIN
LIGASE RBX1
(Homo
sapiens;
Mus
musculus) 		4 / 4 TRP B  27
LEU A 543
LEU A 597
THR A 596
 None
 0.92A 4bboD-4a0kB:
undetectable		 4bboD-4a0kB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 4a0k CULLIN-4A
(Homo
sapiens) 		3 / 3 LYS A 411
LEU A 408
ALA A 410
 None
 0.74A 4ikiA-4a0kA:
undetectable		 4ikiA-4a0kA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4a0k DNA DAMAGE-BINDING
PROTEIN 2
(Danio
rerio) 		5 / 12 GLN D 127
LEU D 387
VAL D 389
ILE D 408
LEU D 420
 None
 1.50A 4k38B-4a0kD:
undetectable		 4k38B-4a0kD:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 4a0k CULLIN-4A
(Homo
sapiens) 		3 / 3 TYR A 536
GLN A 673
TRP A 569
 None
 1.05A 4kn2C-4a0kA:
undetectable		 4kn2C-4a0kA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_A_ACTA404_0
(PROTON-GATED ION
CHANNEL)		 4a0k DNA DAMAGE-BINDING
PROTEIN 2
(Danio
rerio) 		4 / 4 LEU D 416
ILE D 364
ARG D 392
TYR D 409
 None
 1.28A 4zzbA-4a0kD:
undetectable		 4zzbA-4a0kD:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA406_0
(PROTON-GATED ION
CHANNEL)		 4a0k DNA DAMAGE-BINDING
PROTEIN 2
(Danio
rerio) 		4 / 4 LEU D 416
ILE D 364
ARG D 392
TYR D 409
 None
 1.19A 4zzcA-4a0kD:
undetectable		 4zzcA-4a0kD:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB406_0
(PROTON-GATED ION
CHANNEL)		 4a0k DNA DAMAGE-BINDING
PROTEIN 2
(Danio
rerio) 		4 / 4 LEU D 416
ILE D 364
ARG D 392
TYR D 409
 None
 1.18A 4zzcB-4a0kD:
undetectable		 4zzcB-4a0kD:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4a0k DNA DAMAGE-BINDING
PROTEIN 2
(Danio
rerio) 		4 / 6 LEU D 450
SER D 144
PRO D 145
PHE D 447
 None
 1.17A 5b8iA-4a0kD:
undetectable		 5b8iA-4a0kD:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4a0k DNA DAMAGE-BINDING
PROTEIN 2
(Danio
rerio) 		4 / 6 GLU D 324
GLY D 391
ASP D 407
ARG D 392
 None
 0.74A 5cdnA-4a0kD:
undetectable
5cdnB-4a0kD:
undetectable		 5cdnA-4a0kD:
19.59
5cdnB-4a0kD:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4a0k DNA DAMAGE-BINDING
PROTEIN 2
(Danio
rerio) 		4 / 6 GLU D 324
GLY D 391
ASP D 407
ARG D 392
 None
 0.92A 5cdnR-4a0kD:
undetectable
5cdnS-4a0kD:
undetectable		 5cdnR-4a0kD:
19.59
5cdnS-4a0kD:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4a0k CULLIN-4A
(Homo
sapiens) 		4 / 6 TYR A 103
MET A 146
ILE A 170
ASP A 157
 None
 1.21A 5iwuA-4a0kA:
undetectable		 5iwuA-4a0kA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 4a0k CULLIN-4A
(Homo
sapiens) 		5 / 11 ILE A 376
PHE A 380
TRP A 340
VAL A 316
LEU A 311
 None
 1.24A 5jkwA-4a0kA:
undetectable		 5jkwA-4a0kA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 4a0k CULLIN-4A
(Homo
sapiens) 		4 / 6 GLU A 450
PHE A 689
THR A 685
PHE A 487
 None
 1.10A 5lrbA-4a0kA:
undetectable		 5lrbA-4a0kA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4a0k DNA DAMAGE-BINDING
PROTEIN 2
(Danio
rerio) 		5 / 12 ILE D 195
GLY D 170
GLY D 188
LEU D 208
VAL D 210
 None
 0.91A 5twjA-4a0kD:
undetectable		 5twjA-4a0kD:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4a0k DNA DAMAGE-BINDING
PROTEIN 2
(Danio
rerio) 		5 / 10 ILE D 195
GLY D 170
GLY D 188
LEU D 208
VAL D 210
 None
 0.92A 5twjB-4a0kD:
undetectable		 5twjB-4a0kD:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4a0k DNA DAMAGE-BINDING
PROTEIN 2
(Danio
rerio) 		5 / 11 ILE D 195
GLY D 170
GLY D 188
LEU D 208
VAL D 210
 None
 0.92A 5twjD-4a0kD:
undetectable		 5twjD-4a0kD:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 4a0k DNA DAMAGE-BINDING
PROTEIN 2
(Danio
rerio) 		5 / 10 GLY D 170
GLY D 169
ALA D 194
THR D 196
GLY D 166
 None
 1.09A 6e5zA-4a0kD:
undetectable		 6e5zA-4a0kD:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4a0k CULLIN-4A
(Homo
sapiens) 		3 / 3 ALA A 406
PHE A 452
GLN A 681
 None
 0.79A 6eceA-4a0kA:
undetectable		 6eceA-4a0kA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4a0k DNA DAMAGE-BINDING
PROTEIN 2
(Danio
rerio) 		4 / 5 GLY D 255
THR D 254
SER D 212
SER D 211
 None
 0.95A 6jmjA-4a0kD:
undetectable		 6jmjA-4a0kD:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4a0k DNA DAMAGE-BINDING
PROTEIN 2
(Danio
rerio) 		4 / 7 GLY D 255
THR D 254
SER D 212
SER D 211
 None
 0.96A 6jnhA-4a0kD:
undetectable		 6jnhA-4a0kD:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4a0k DNA DAMAGE-BINDING
PROTEIN 2
(Danio
rerio) 		4 / 6 GLY D 255
THR D 254
SER D 212
SER D 211
 None
 0.95A 6jogA-4a0kD:
undetectable		 6jogA-4a0kD:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 4a0k CULLIN-4A
(Homo
sapiens) 		4 / 8 GLY A 331
LEU A 295
GLY A 296
LEU A 299
 None
 0.78A 6mdqA-4a0kA:
undetectable		 6mdqA-4a0kA:
8.62