SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a0l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 4a0l CULLIN-4B
(Homo
sapiens) 		4 / 5 LEU E 421
ASP E 426
LEU E 475
HIS E 416
 None
 1.19A 2jfaA-4a0lE:
undetectable		 2jfaA-4a0lE:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 4a0l CULLIN-4B
(Homo
sapiens) 		5 / 9 THR E 781
LEU E 747
LEU E 754
LEU E 778
THR E 771
 None
 1.27A 2npnA-4a0lE:
undetectable		 2npnA-4a0lE:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 4a0l CULLIN-4B
(Homo
sapiens) 		4 / 6 ARG E 555
PHE E 551
ILE E 552
PHE E 548
 None
 1.15A 2qeiA-4a0lE:
2.7		 2qeiA-4a0lE:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4a0l CULLIN-4B
(Homo
sapiens) 		3 / 3 SER E 282
GLU E 355
ASP E 348
 None
 0.83A 2zthA-4a0lE:
undetectable		 2zthA-4a0lE:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 4a0l CULLIN-4B
(Homo
sapiens) 		3 / 3 MET E 652
GLU E 626
ASP E 568
 None
 1.06A 3a25A-4a0lE:
undetectable		 3a25A-4a0lE:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 4a0l CULLIN-4B
(Homo
sapiens) 		4 / 6 SER E 282
ILE E 354
GLU E 355
ASP E 348
 None
 0.69A 3a7eA-4a0lE:
undetectable		 3a7eA-4a0lE:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4a0l CULLIN-4B
(Homo
sapiens) 		3 / 3 SER E 282
GLU E 355
ASP E 348
 None
 0.87A 3bwmA-4a0lE:
undetectable		 3bwmA-4a0lE:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4a0l CULLIN-4B
(Homo
sapiens) 		3 / 3 TYR E 235
GLU E 225
ASP E 266
 None
 0.86A 3bxoA-4a0lE:
undetectable		 3bxoA-4a0lE:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4a0l CULLIN-4B
(Homo
sapiens) 		3 / 3 TYR E 235
GLU E 225
ASP E 266
 None
 0.86A 3bxoB-4a0lE:
undetectable		 3bxoB-4a0lE:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4a0l CULLIN-4B
(Homo
sapiens) 		3 / 3 CYH E 787
PRO E 797
ASP E 801
 None
 0.91A 3hlwB-4a0lE:
undetectable		 3hlwB-4a0lE:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 4a0l CULLIN-4B
(Homo
sapiens) 		3 / 3 ARG E 369
ILE E 350
THR E 393
 None
 0.71A 3ia4D-4a0lE:
undetectable		 3ia4D-4a0lE:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 4a0l CULLIN-4B
(Homo
sapiens) 		4 / 6 LEU E 375
SER E 384
PHE E 385
ILE E 350
 None
 1.00A 3ko0B-4a0lE:
undetectable		 3ko0B-4a0lE:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 4a0l CULLIN-4B
(Homo
sapiens) 		3 / 3 ARG E 889
TYR E 598
ASN E 557
 None
 0.84A 4ffwB-4a0lE:
undetectable		 4ffwB-4a0lE:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 4a0l CULLIN-4B
(Homo
sapiens) 		3 / 3 TYR E 690
GLN E 827
TRP E 723
 None
 1.13A 4kn2C-4a0lE:
undetectable		 4kn2C-4a0lE:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 4a0l CULLIN-4B
(Homo
sapiens) 		5 / 11 ARG E 779
LEU E 782
ASP E 806
LEU E 764
LEU E 793
 None
 1.28A 4or0A-4a0lE:
undetectable		 4or0A-4a0lE:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 4a0l CULLIN-4B
(Homo
sapiens) 		3 / 3 CYH E 787
PRO E 797
ASP E 801
 None
 0.86A 4pm5A-4a0lE:
undetectable		 4pm5A-4a0lE:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_ACTA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4a0l CULLIN-4B
(Homo
sapiens) 		4 / 4 ALA E 612
LYS E 613
TYR E 690
GLU E 834
 None
 1.14A 4rvdA-4a0lE:
0.0		 4rvdA-4a0lE:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_ACTA504_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4a0l CULLIN-4B
(Homo
sapiens) 		4 / 4 ALA E 612
LYS E 613
TYR E 690
GLU E 834
 None
 1.20A 4rvgA-4a0lE:
0.0		 4rvgA-4a0lE:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4a0l CULLIN-4B
(Homo
sapiens) 		3 / 3 GLU E 423
TYR E 397
GLU E 400
 None
 0.70A 4ryaA-4a0lE:
undetectable		 4ryaA-4a0lE:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4a0l CULLIN-4B
(Homo
sapiens) 		3 / 3 MET E 586
ASP E 521
PHE E 522
 None
 0.94A 4xeyA-4a0lE:
undetectable		 4xeyA-4a0lE:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4a0l CULLIN-4B
(Homo
sapiens) 		3 / 3 MET E 586
ASP E 521
PHE E 522
 None
 0.90A 4xeyB-4a0lE:
undetectable		 4xeyB-4a0lE:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4a0l CULLIN-4B
(Homo
sapiens) 		4 / 4 SER E 622
GLU E 584
SER E 631
ASP E 624
 None
 1.11A 4xucA-4a0lE:
undetectable		 4xucA-4a0lE:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4a0l CULLIN-4B
(Homo
sapiens) 		3 / 3 SER E 282
GLU E 355
ASP E 348
 None
 0.83A 4xudA-4a0lE:
undetectable		 4xudA-4a0lE:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 4a0l CULLIN-4B
(Homo
sapiens) 		4 / 6 GLU E 604
PHE E 843
THR E 839
PHE E 641
 None
 1.29A 5lrbA-4a0lE:
undetectable		 5lrbA-4a0lE:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 4a0l CULLIN-4B
(Homo
sapiens) 		4 / 7 SER E 282
ILE E 354
GLU E 355
ASP E 348
 None
 0.73A 5n5dA-4a0lE:
undetectable		 5n5dA-4a0lE:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4a0l CULLIN-4B
(Homo
sapiens) 		3 / 3 LYS E 882
PRO E 883
LYS E 887
 None
 1.30A 5y9yA-4a0lE:
undetectable		 5y9yA-4a0lE:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4a0l CULLIN-4B
(Homo
sapiens) 		5 / 6 SER E 282
GLY E 349
THR E 346
ILE E 337
PHE E 332
 None
 1.45A 6f8cA-4a0lE:
undetectable		 6f8cA-4a0lE:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4a0l CULLIN-4B
(Homo
sapiens) 		4 / 7 ASP E 512
ARG E 555
LYS E 565
GLN E 835
 None
 1.26A 6g31A-4a0lE:
undetectable		 6g31A-4a0lE:
7.73