SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a0w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		5 / 12 LEU A 270
ALA A 294
PRO A 216
GLY A 273
ILE A 274
 None
 1.17A 1kglA-4a0wA:
undetectable		 1kglA-4a0wA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		5 / 11 ILE A 369
LEU A 370
HIS A 162
SER A 376
GLU A 372
 None
 1.50A 1kyvA-4a0wA:
undetectable
1kyvB-4a0wA:
undetectable		 1kyvA-4a0wA:
16.41
1kyvB-4a0wA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		4 / 7 GLU A  95
ALA A  19
LEU A  71
ALA A 497
 None
 1.01A 1sn0B-4a0wA:
undetectable
1sn0D-4a0wA:
undetectable		 1sn0B-4a0wA:
15.81
1sn0D-4a0wA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_A_ACTA4901_0
(PYRANOSE OXIDASE)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		4 / 6 THR A 229
PHE A 322
PHE A 277
ASN A 279
 None
 1.46A 1tt0A-4a0wA:
undetectable		 1tt0A-4a0wA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_B_ACTB3901_0
(PYRANOSE OXIDASE)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		4 / 6 THR A 229
PHE A 322
PHE A 277
ASN A 279
 None
 1.45A 1tt0B-4a0wA:
undetectable		 1tt0B-4a0wA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		4 / 6 THR A 229
PHE A 322
PHE A 277
ASN A 279
 None
 1.45A 1tt0C-4a0wA:
undetectable		 1tt0C-4a0wA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_D_ACTD5901_0
(PYRANOSE OXIDASE)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		4 / 6 THR A 229
PHE A 322
PHE A 277
ASN A 279
 None
 1.46A 1tt0D-4a0wA:
undetectable		 1tt0D-4a0wA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		5 / 10 ARG A 375
GLY A  34
THR A 160
GLU A 372
SER A  28
 None
 1.46A 1z35A-4a0wA:
undetectable		 1z35A-4a0wA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		4 / 7 ALA A 120
THR A 121
ALA A 124
ARG A 488
 None
 0.94A 2ql8A-4a0wA:
undetectable
2ql8B-4a0wA:
undetectable		 2ql8A-4a0wA:
15.05
2ql8B-4a0wA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		5 / 11 GLY A 473
ALA A 455
ASP A 466
ILE A 472
GLN A 451
 None
 1.31A 3id5B-4a0wA:
undetectable		 3id5B-4a0wA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		5 / 11 GLY A 473
ALA A 455
ASP A 466
ILE A 472
GLN A 451
 None
 1.31A 3id5F-4a0wA:
undetectable		 3id5F-4a0wA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		5 / 12 VAL A 383
ALA A 385
LEU A 384
ILE A 360
LEU A 377
 None
 1.04A 3mb5A-4a0wA:
undetectable		 3mb5A-4a0wA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		3 / 3 ARG A 375
VAL A 383
THR A 153
 None
 0.79A 3ndtA-4a0wA:
undetectable		 3ndtA-4a0wA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		5 / 10 LEU A  58
LEU A  25
ILE A  22
ALA A  21
VAL A  63
 None
 1.23A 3r9cA-4a0wA:
undetectable		 3r9cA-4a0wA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		4 / 6 GLY A  31
ASN A 440
GLU A 482
ILE A 480
 None
 0.64A 4fglD-4a0wA:
undetectable		 4fglD-4a0wA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJH_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		5 / 12 GLU A 482
GLU A  95
GLU A 401
LYS A 487
ASP A  84
 None
 1.48A 4njhA-4a0wA:
1.2		 4njhA-4a0wA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJI_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		5 / 12 GLU A 482
GLU A  95
GLU A 401
LYS A 487
ASP A  84
 None
 1.48A 4njiA-4a0wA:
1.3		 4njiA-4a0wA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJK_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		5 / 12 GLU A 482
GLU A  95
GLU A 401
LYS A 487
ASP A  84
 None
 1.50A 4njkA-4a0wA:
1.3		 4njkA-4a0wA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJK_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		5 / 12 GLU A 482
GLU A  95
GLU A 401
LYS A 487
ASP A  84
 None
 1.48A 4njkB-4a0wA:
1.2		 4njkB-4a0wA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		5 / 9 THR A  29
THR A  86
ILE A  57
ALA A  55
ASP A  79
 None
 1.19A 4qvqK-4a0wA:
undetectable
4qvqL-4a0wA:
undetectable		 4qvqK-4a0wA:
18.90
4qvqL-4a0wA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		4 / 7 GLU A 317
THR A 314
GLY A 316
HIS A 272
 None
 0.88A 4qwpB-4a0wA:
undetectable		 4qwpB-4a0wA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		4 / 7 THR A  29
LEU A  30
THR A  90
THR A  87
 None
 0.96A 4z91F-4a0wA:
undetectable
4z91G-4a0wA:
undetectable
4z91H-4a0wA:
undetectable
4z91I-4a0wA:
undetectable
4z91J-4a0wA:
undetectable		 4z91F-4a0wA:
20.68
4z91G-4a0wA:
20.68
4z91H-4a0wA:
20.68
4z91I-4a0wA:
20.68
4z91J-4a0wA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		5 / 9 THR A 481
ILE A 480
GLY A  85
LEU A 384
LEU A 146
 None
 1.31A 4ze0A-4a0wA:
undetectable		 4ze0A-4a0wA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		4 / 6 GLU A 337
GLY A 364
ASP A 198
GLY A 193
 None
 0.93A 5cdnC-4a0wA:
undetectable
5cdnD-4a0wA:
undetectable		 5cdnC-4a0wA:
24.09
5cdnD-4a0wA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		4 / 7 LEU A 128
ILE A 480
THR A 481
MET A 475
 None
 1.43A 5ljcA-4a0wA:
undetectable		 5ljcA-4a0wA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		5 / 9 LEU A 465
MET A 467
MET A  35
GLY A  31
LEU A  30
 None
 1.49A 5wgqA-4a0wA:
undetectable		 5wgqA-4a0wA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Bos
taurus) 		5 / 10 ASN A 279
GLU A 288
PHE A 277
ALA A 227
ILE A 269
 None
 1.25A 6bniB-4a0wA:
undetectable		 6bniB-4a0wA:
9.34