SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a11'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8
(Homo
sapiens) 		5 / 12 LEU B 261
ASN B 289
VAL B 211
LYS B 247
ALA B 205
 None
 1.20A 1sa1C-4a11B:
undetectable
1sa1D-4a11B:
undetectable		 1sa1C-4a11B:
21.88
1sa1D-4a11B:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8
(Homo
sapiens) 		4 / 8 TYR B  58
TYR B 350
ARG B  36
VAL B 341
 None
 1.01A 2fl5E-4a11B:
undetectable
2fl5F-4a11B:
undetectable		 2fl5E-4a11B:
20.50
2fl5F-4a11B:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8
(Homo
sapiens) 		5 / 12 ILE B 201
ASP B 215
VAL B 216
ARG B 217
VAL B 159
 None
 0.68A 2qe6A-4a11B:
undetectable		 2qe6A-4a11B:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8
(Homo
sapiens) 		5 / 12 ILE B 201
ASP B 215
VAL B 216
ARG B 217
VAL B 159
 None
 0.83A 2qe6B-4a11B:
undetectable		 2qe6B-4a11B:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8
(Homo
sapiens) 		4 / 5 LEU B 330
GLN B 326
THR B 328
HIS B 333
 None
 1.29A 3ce6B-4a11B:
undetectable		 3ce6B-4a11B:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8
(Homo
sapiens) 		5 / 12 THR B 123
ALA B 135
VAL B 159
ILE B  90
THR B 129
 None
 1.12A 3czhA-4a11B:
undetectable		 3czhA-4a11B:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8
(Homo
sapiens) 		5 / 12 THR B 123
ALA B 135
VAL B 159
ILE B  90
THR B 129
 None
 1.10A 3czhB-4a11B:
undetectable		 3czhB-4a11B:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8
(Homo
sapiens) 		5 / 12 THR B 123
ALA B 135
VAL B 159
ILE B  90
THR B 129
 None
 1.14A 3dl9A-4a11B:
undetectable		 3dl9A-4a11B:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8
(Homo
sapiens) 		5 / 12 LEU B 132
HIS B  94
THR B 134
HIS B  98
PHE B 115
 None
 1.37A 3n58D-4a11B:
undetectable		 3n58D-4a11B:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5V_C_ACTC510_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8
(Homo
sapiens) 		4 / 5 ARG B 354
ASP B 338
LYS B 293
GLU B 103
 None
 1.37A 3v5vC-4a11B:
undetectable
3v5vD-4a11B:
undetectable		 3v5vC-4a11B:
20.39
3v5vD-4a11B:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8
(Homo
sapiens) 		5 / 9 GLY B  66
HIS B  98
SER B  61
VAL B 105
LEU B  60
 None
 1.14A 4qd3A-4a11B:
undetectable		 4qd3A-4a11B:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8
(Homo
sapiens) 		3 / 3 GLY B 176
CYH B 178
CYH B 171
 None
 0.67A 5inzB-4a11B:
undetectable		 5inzB-4a11B:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8
(Homo
sapiens) 		5 / 12 LEU B 226
ALA B 191
SER B 146
LEU B 260
ARG B 270
 None
 1.21A 6ew0F-4a11B:
undetectable		 6ew0F-4a11B:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8
(Homo
sapiens) 		5 / 12 LEU B 226
ALA B 191
SER B 146
LEU B 260
ARG B 270
 None
 1.21A 6ew0G-4a11B:
undetectable		 6ew0G-4a11B:
10.84