SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a14'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4a14 KINESIN-LIKE PROTEIN
KIF7
(Homo
sapiens) 		4 / 8 LEU A 286
GLU A  10
ILE A 296
TYR A 298
 None
 1.08A 1qvtA-4a14A:
undetectable		 1qvtA-4a14A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4a14 KINESIN-LIKE PROTEIN
KIF7
(Homo
sapiens) 		3 / 3 SER A 253
ASP A 329
CYH A  34
 None
 1.00A 2br4E-4a14A:
undetectable		 2br4E-4a14A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4a14 KINESIN-LIKE PROTEIN
KIF7
(Homo
sapiens) 		4 / 8 THR A 336
SER A 253
SER A  95
CYH A 322
 None
None
ADP  A1345 (-3.5A)
None
 1.23A 2xz5C-4a14A:
undetectable
2xz5D-4a14A:
undetectable		 2xz5C-4a14A:
17.85
2xz5D-4a14A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4a14 KINESIN-LIKE PROTEIN
KIF7
(Homo
sapiens) 		4 / 6 LEU A  41
GLU A  38
PRO A  39
HIS A  51
 None
 1.50A 3ltwA-4a14A:
undetectable		 3ltwA-4a14A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4a14 KINESIN-LIKE PROTEIN
KIF7
(Homo
sapiens) 		5 / 12 MET A 101
ALA A 120
GLU A 123
LEU A  76
ILE A 320
 None
 0.91A 3olsB-4a14A:
undetectable		 3olsB-4a14A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 4a14 KINESIN-LIKE PROTEIN
KIF7
(Homo
sapiens) 		4 / 6 HIS A  31
GLU A  26
LEU A  22
ASP A 329
 None
 1.50A 4cevA-4a14A:
undetectable
4cevB-4a14A:
undetectable		 4cevA-4a14A:
23.92
4cevB-4a14A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 4a14 KINESIN-LIKE PROTEIN
KIF7
(Homo
sapiens) 		4 / 6 ASP A 329
HIS A  31
GLU A  26
LEU A  22
 None
 1.50A 4cevA-4a14A:
1.7
4cevC-4a14A:
1.7		 4cevA-4a14A:
23.92
4cevC-4a14A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 4a14 KINESIN-LIKE PROTEIN
KIF7
(Homo
sapiens) 		4 / 6 HIS A  31
GLU A  26
LEU A  22
ASP A 329
 None
 1.49A 4cevD-4a14A:
undetectable
4cevE-4a14A:
undetectable		 4cevD-4a14A:
23.92
4cevE-4a14A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 4a14 KINESIN-LIKE PROTEIN
KIF7
(Homo
sapiens) 		4 / 6 HIS A  31
GLU A  26
LEU A  22
ASP A 329
 None
 1.50A 4cevE-4a14A:
undetectable
4cevF-4a14A:
undetectable		 4cevE-4a14A:
23.92
4cevF-4a14A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4a14 KINESIN-LIKE PROTEIN
KIF7
(Homo
sapiens) 		4 / 7 GLU A  65
ARG A  18
GLY A 115
ARG A 119
 None
ADP  A1345 (-3.6A)
None
None
 1.07A 4fgzA-4a14A:
undetectable		 4fgzA-4a14A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 4a14 KINESIN-LIKE PROTEIN
KIF7
(Homo
sapiens) 		3 / 3 ASP A 135
ASN A 131
PHE A  79
 None
 0.79A 5dsgB-4a14A:
undetectable		 5dsgB-4a14A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4a14 KINESIN-LIKE PROTEIN
KIF7
(Homo
sapiens) 		5 / 12 ALA A 321
LEU A 337
ALA A  89
GLY A  91
SER A 253
 None
 1.42A 5jglA-4a14A:
undetectable		 5jglA-4a14A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4a14 KINESIN-LIKE PROTEIN
KIF7
(Homo
sapiens) 		4 / 7 VAL A 318
ILE A 320
VAL A  56
ALA A  16
 None
 0.66A 5osrA-4a14A:
undetectable		 5osrA-4a14A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4a14 KINESIN-LIKE PROTEIN
KIF7
(Homo
sapiens) 		4 / 8 HIS A 215
VAL A 217
VAL A 248
LEU A 307
 None
 0.85A 5tt3F-4a14A:
undetectable		 5tt3F-4a14A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4a14 KINESIN-LIKE PROTEIN
KIF7
(Homo
sapiens) 		6 / 12 SER A 310
VAL A 145
PHE A  88
LEU A 276
LEU A 250
VAL A 248
 None
 1.43A 5tudA-4a14A:
undetectable		 5tudA-4a14A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 4a14 KINESIN-LIKE PROTEIN
KIF7
(Homo
sapiens) 		5 / 12 VAL A  13
VAL A  56
ALA A  70
PHE A  88
LEU A 250
 None
 1.36A 6a7pB-4a14A:
undetectable		 6a7pB-4a14A:
20.44