SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a1f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 4a1f REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		5 / 10 ASN A 447
SER A 191
GLY A 192
ASN A 445
GLY A 178
 None
 1.31A 1ho5B-4a1fA:
2.0		 1ho5B-4a1fA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 4a1f REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		3 / 3 ASP A 374
LEU A 315
LEU A 317
 None
 0.73A 1ikeA-4a1fA:
undetectable		 1ikeA-4a1fA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 4a1f REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		5 / 12 ILE A 372
THR A 455
VAL A 453
LEU A 212
ILE A 201
 None
 1.28A 1kqwA-4a1fA:
0.9		 1kqwA-4a1fA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 4a1f REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		3 / 3 ASP A 374
LEU A 315
LEU A 317
 None
 0.69A 1np1B-4a1fA:
undetectable		 1np1B-4a1fA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 4a1f REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		3 / 3 TYR A 464
ARG A 204
GLN A 354
 None
 0.96A 1tw4A-4a1fA:
undetectable		 1tw4A-4a1fA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD205_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4a1f REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		5 / 10 MET A 234
GLU A 256
MET A 214
MET A 213
SER A 211
 FLC  A1474 (-4.0A)
None
None
None
FLC  A1474 (-2.9A)
 1.21A 1wrlC-4a1fA:
undetectable
1wrlD-4a1fA:
undetectable		 1wrlC-4a1fA:
15.22
1wrlD-4a1fA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 4a1f REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		4 / 8 ILE A 200
PHE A 387
LEU A 317
LEU A 355
 None
 0.73A 2w98B-4a1fA:
2.3		 2w98B-4a1fA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4a1f REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		4 / 8 ILE A 347
ALA A 310
LEU A 341
ALA A 351
 None
 0.95A 3hrdA-4a1fA:
undetectable
3hrdB-4a1fA:
undetectable		 3hrdA-4a1fA:
20.31
3hrdB-4a1fA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 4a1f REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		5 / 12 LEU A 218
VAL A 227
GLY A 226
LEU A 307
LEU A 275
 None
 1.14A 3ijdB-4a1fA:
undetectable		 3ijdB-4a1fA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 4a1f REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		3 / 3 TYR A 287
TYR A 314
GLU A 326
 None
 0.91A 3pfgA-4a1fA:
3.1		 3pfgA-4a1fA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 4a1f REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		4 / 8 ILE A 384
LYS A 209
ILE A 440
PHE A 387
 None
FLC  A1474 (-3.2A)
None
None
 0.91A 4hdlA-4a1fA:
undetectable		 4hdlA-4a1fA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4a1f REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		3 / 3 GLU A 437
ARG A 456
HIS A 472
 None
 0.85A 4kf9A-4a1fA:
undetectable		 4kf9A-4a1fA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4a1f REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		3 / 3 ILE A 334
ASP A 374
ARG A 289
 None
 0.64A 4pstA-4a1fA:
undetectable		 4pstA-4a1fA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4a1f REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		5 / 12 LEU A 198
ILE A 290
ILE A 200
ALA A 351
ILE A 331
 None
 1.25A 4rp8C-4a1fA:
3.4		 4rp8C-4a1fA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 4a1f REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		3 / 3 ASP A 262
ASN A 267
PHE A 272
 None
 0.71A 5dsgB-4a1fA:
undetectable		 5dsgB-4a1fA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4a1f REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		4 / 6 ASP A 371
ILE A 441
ARG A 366
TYR A 389
 None
 1.02A 5igyA-4a1fA:
undetectable		 5igyA-4a1fA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4a1f REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		4 / 6 ASP A 371
ILE A 441
ARG A 366
TYR A 389
 None
 1.04A 5iwuA-4a1fA:
undetectable		 5iwuA-4a1fA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4a1f REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		5 / 12 ILE A 201
ALA A 203
GLN A 354
ILE A 372
LEU A 352
 None
 1.12A 6a5zD-4a1fA:
undetectable		 6a5zD-4a1fA:
12.30