SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a1o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  14
VAL A 108
VAL A  78
HIS A  79
LEU A  74
 None
None
None
None
JLN  A1528 (-4.1A)
 1.07A 1db1A-4a1oA:
undetectable		 1db1A-4a1oA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 267
LEU A 361
THR A 336
ILE A 358
LEU A 352
 None
 0.96A 1ddrA-4a1oA:
undetectable		 1ddrA-4a1oA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 352
GLY A 315
ILE A 281
VAL A 360
ILE A 358
 None
 0.91A 1ohrB-4a1oA:
undetectable		 1ohrB-4a1oA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 164
GLY A  29
LEU A  26
ILE A  37
 None
 0.96A 1yajF-4a1oA:
undetectable		 1yajF-4a1oA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 5 ALA A 363
ALA A 271
ALA A 280
VAL A 316
 None
 0.93A 2nyrB-4a1oA:
5.1		 2nyrB-4a1oA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 154
ASP A 153
SER A 114
ASP A  19
 None
 1.22A 2obvA-4a1oA:
undetectable		 2obvA-4a1oA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 5 SER A 385
GLY A 369
HIS A 274
ASP A 389
 None
 1.12A 2oxtB-4a1oA:
undetectable		 2oxtB-4a1oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 154
ASP A 153
SER A 114
ASP A  19
 None
 1.15A 2p02A-4a1oA:
undetectable		 2p02A-4a1oA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 4 LYS A 143
LEU A  83
ALA A 142
LEU A  82
 None
 1.29A 2roxA-4a1oA:
undetectable		 2roxA-4a1oA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		5 / 10 THR A  73
VAL A  57
ASN A 109
VAL A 108
GLY A 134
 JLN  A1528 (-2.7A)
None
None
None
JLN  A1528 (-3.2A)
 1.42A 2x2iD-4a1oA:
1.7		 2x2iD-4a1oA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 108
VAL A  17
THR A  73
THR A 152
 None
None
JLN  A1528 (-2.7A)
None
 1.27A 3bjwD-4a1oA:
undetectable		 3bjwD-4a1oA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 347
ILE A 339
SER A 324
VAL A 325
ALA A 328
 None
 0.97A 3dcmX-4a1oA:
undetectable		 3dcmX-4a1oA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 5 ASN A 394
ARG A 419
HIS A 520
ALA A 518
 None
 1.22A 3frqA-4a1oA:
undetectable		 3frqA-4a1oA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 394
ARG A 419
HIS A 520
ALA A 518
 None
 1.20A 3frqB-4a1oA:
undetectable		 3frqB-4a1oA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  13
SER A  39
GLY A 159
ALA A 163
ILE A  10
 None
 1.28A 3lbdA-4a1oA:
undetectable		 3lbdA-4a1oA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  82
PHE A 103
ILE A  38
THR A  40
THR A  73
 None
None
None
JLN  A1528 (-4.0A)
JLN  A1528 (-2.7A)
 1.31A 3mdtA-4a1oA:
undetectable		 3mdtA-4a1oA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 312
ILE A 281
HIS A 301
VAL A 331
 None
 0.97A 3nneG-4a1oA:
undetectable		 3nneG-4a1oA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  22
ILE A  10
GLY A  29
ALA A  27
ALA A  13
 None
 1.02A 3sudC-4a1oA:
undetectable		 3sudC-4a1oA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 478
LEU A 482
ALA A 471
ASP A 470
SER A 469
 None
None
None
K  A1524 (-3.6A)
None
 0.89A 3tbgB-4a1oA:
undetectable		 3tbgB-4a1oA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 478
LEU A 482
ALA A 471
ASP A 470
SER A 469
 None
None
None
K  A1524 (-3.6A)
None
 0.91A 3tbgD-4a1oA:
undetectable		 3tbgD-4a1oA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 267
LEU A 361
THR A 336
ILE A 358
LEU A 352
 None
 1.02A 4i13A-4a1oA:
undetectable		 4i13A-4a1oA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		6 / 10 LEU A  82
PHE A 103
VAL A 106
ILE A  38
THR A  40
THR A  73
 None
None
None
None
JLN  A1528 (-4.0A)
JLN  A1528 (-2.7A)
 1.17A 4j14A-4a1oA:
1.2		 4j14A-4a1oA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 154
ASP A 153
SER A 114
ASP A  19
 None
 1.19A 4kttC-4a1oA:
undetectable		 4kttC-4a1oA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 154
ASP A 153
SER A 114
ASP A  19
 None
 1.18A 4ndnA-4a1oA:
undetectable		 4ndnA-4a1oA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 7 PRO A 154
ASP A 153
SER A 114
ASP A  19
 None
 1.20A 4ndnC-4a1oA:
undetectable		 4ndnC-4a1oA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 7 PRO A 154
ASP A 153
SER A 114
ASP A  19
 None
 1.26A 4odjA-4a1oA:
undetectable		 4odjA-4a1oA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 352
GLY A 315
ILE A 281
VAL A 360
ILE A 358
 None
 0.89A 4qgiB-4a1oA:
undetectable		 4qgiB-4a1oA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 478
LEU A 482
ALA A 471
ASP A 470
SER A 469
 None
None
None
K  A1524 (-3.6A)
None
 1.03A 4wnuC-4a1oA:
undetectable		 4wnuC-4a1oA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 478
LEU A 482
ASP A 470
VAL A 490
VAL A 440
 None
None
K  A1524 (-3.6A)
None
None
 1.00A 4wnwA-4a1oA:
undetectable		 4wnwA-4a1oA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 478
LEU A 482
ALA A 471
ASP A 470
VAL A 490
 None
None
None
K  A1524 (-3.6A)
None
 0.94A 4wnwB-4a1oA:
undetectable		 4wnwB-4a1oA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 478
LEU A 482
ASP A 470
VAL A 490
VAL A 440
 None
None
K  A1524 (-3.6A)
None
None
 1.06A 4wnwB-4a1oA:
undetectable		 4wnwB-4a1oA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 263
ILE A 282
THR A 262
LYS A 425
 None
 1.12A 4zxiA-4a1oA:
3.0		 4zxiA-4a1oA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 154
ASP A 153
SER A 114
ASP A  19
 None
 1.16A 5a1iA-4a1oA:
undetectable		 5a1iA-4a1oA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 7 PRO A 154
ASP A 153
SER A 114
ASP A  19
 None
 1.16A 5a1iA-4a1oA:
undetectable		 5a1iA-4a1oA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  82
THR A  73
GLY A  81
PHE A 103
LEU A  14
 None
JLN  A1528 (-2.7A)
None
None
None
 1.33A 5jo9A-4a1oA:
4.4		 5jo9A-4a1oA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 273
ARG A 269
ASP A 389
 None
 0.82A 5zvgA-4a1oA:
2.8		 5zvgA-4a1oA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 273
ARG A 269
ASP A 389
 None
 0.85A 5zvgB-4a1oA:
undetectable		 5zvgB-4a1oA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 455
LEU A 513
LEU A 479
THR A 512
GLY A 464
 None
 1.15A 6b0lB-4a1oA:
undetectable		 6b0lB-4a1oA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 154
ASP A 153
SER A 114
ASP A  19
 None
 1.22A 6fbnB-4a1oA:
undetectable		 6fbnB-4a1oA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 154
ASP A 153
SER A 114
ASP A  19
 None
 1.18A 6fboA-4a1oA:
undetectable		 6fboA-4a1oA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 154
ASP A 153
SER A 114
ASP A  19
 None
 1.18A 6fcbA-4a1oA:
undetectable		 6fcbA-4a1oA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 154
ASP A 153
SER A 114
ASP A  19
 None
 1.16A 6fcdA-4a1oA:
undetectable		 6fcdA-4a1oA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 7 PRO A 154
ASP A 153
SER A 114
ASP A  19
 None
 1.15A 6g6rA-4a1oA:
undetectable		 6g6rA-4a1oA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 4 LYS A 143
LEU A  83
ALA A 142
LEU A  82
 None
 1.23A 6gnrA-4a1oA:
undetectable		 6gnrA-4a1oA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Mycobacterium
tuberculosis) 		4 / 4 LYS A 143
LEU A  83
ALA A 142
LEU A  82
 None
 1.22A 6gnrB-4a1oA:
undetectable		 6gnrB-4a1oA:
14.31