SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a1s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 4a1s PARTNER OF
INSCUTEABLE
(Drosophila
melanogaster) 		4 / 4 LYS A 122
LEU A 118
ALA A 121
LEU A 154
 None
 1.42A 1f86B-4a1sA:
undetectable		 1f86B-4a1sA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 4a1s PARTNER OF
INSCUTEABLE
(Drosophila
melanogaster) 		4 / 6 THR A 227
LEU A 224
GLY A 222
TYR A 201
 None
 1.17A 1gtiC-4a1sA:
1.4		 1gtiC-4a1sA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 4a1s PARTNER OF
INSCUTEABLE
RE60102P
(Drosophila
melanogaster) 		4 / 7 THR A 307
ALA C  20
ASN A 266
PHE A 270
 None
 1.14A 2hzqA-4a1sA:
undetectable		 2hzqA-4a1sA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 4a1s PARTNER OF
INSCUTEABLE
(Drosophila
melanogaster) 		4 / 5 GLU A 337
GLY A 336
TYR A 302
GLN A 299
 None
 1.47A 3w9tD-4a1sA:
undetectable		 3w9tD-4a1sA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 4a1s PARTNER OF
INSCUTEABLE
(Drosophila
melanogaster) 		4 / 5 GLU A 337
GLY A 336
TYR A 302
GLN A 299
 None
 1.43A 3w9tE-4a1sA:
undetectable		 3w9tE-4a1sA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 4a1s PARTNER OF
INSCUTEABLE
(Drosophila
melanogaster) 		4 / 5 GLU A 337
GLY A 336
TYR A 302
GLN A 299
 None
 1.40A 3w9tG-4a1sA:
undetectable		 3w9tG-4a1sA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 4a1s PARTNER OF
INSCUTEABLE
(Drosophila
melanogaster) 		3 / 3 ARG A 283
GLU A 257
ASN A 261
 None
 0.91A 4ip7D-4a1sA:
undetectable		 4ip7D-4a1sA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 4a1s PARTNER OF
INSCUTEABLE
RE60102P
(Drosophila
melanogaster;
Drosophila
melanogaster) 		3 / 3 PRO C   9
ASN A 306
HIS A 321
 None
 0.86A 4ma3H-4a1sC:
undetectable
4ma3L-4a1sC:
undetectable		 4ma3H-4a1sC:
11.76
4ma3L-4a1sC:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4a1s PARTNER OF
INSCUTEABLE
(Drosophila
melanogaster) 		3 / 3 ALA A 163
ASN A 166
LEU A 167
 None
 0.49A 5i1oA-4a1sA:
undetectable		 5i1oA-4a1sA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 4a1s PARTNER OF
INSCUTEABLE
(Drosophila
melanogaster) 		3 / 3 GLY A  57
CYH A  59
CYH A  54
 None
 0.92A 5inzB-4a1sA:
undetectable		 5inzB-4a1sA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 4a1s PARTNER OF
INSCUTEABLE
(Drosophila
melanogaster) 		3 / 3 GLY A  62
CYH A  54
CYH A  59
 None
 0.93A 5inzB-4a1sA:
undetectable		 5inzB-4a1sA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4a1s PARTNER OF
INSCUTEABLE
(Drosophila
melanogaster) 		3 / 3 ASN A  89
TYR A  93
CYH A  54
 None
 1.01A 5lsuB-4a1sA:
undetectable		 5lsuB-4a1sA:
20.71