SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 238
GLU A 192
ALA A 234
LEU A 240
 None
 1.19A 1eta1-4a22A:
undetectable		 1eta1-4a22A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 238
GLU A 192
ALA A 236
LEU A 240
 None
 1.20A 1eta1-4a22A:
undetectable		 1eta1-4a22A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 238
GLU A 192
ALA A 234
LEU A 240
 None
 1.15A 1eta2-4a22A:
undetectable		 1eta2-4a22A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		4 / 6 ALA A  36
LYS A  39
ASP A  43
ALA A  44
 None
 0.29A 1iwhA-4a22A:
undetectable		 1iwhA-4a22A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A 182
VAL A 165
GLY A 230
ILE A 191
TYR A 202
 None
 1.32A 1xvaA-4a22A:
undetectable		 1xvaA-4a22A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		5 / 12 SER A  31
VAL A  34
THR A  94
PHE A 125
PHE A  52
 None
None
NA  A1347 (-3.6A)
None
None
 1.35A 2vdyA-4a22A:
undetectable		 2vdyA-4a22A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		5 / 12 SER A  31
VAL A  34
THR A  94
PHE A 125
PHE A  52
 None
None
NA  A1347 (-3.6A)
None
None
 1.37A 2vdyB-4a22A:
undetectable		 2vdyB-4a22A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		4 / 5 ILE A   3
TYR A  86
ILE A  50
HIS A  93
 None
None
None
NA  A1346 (-4.3A)
 1.24A 3eteB-4a22A:
undetectable
3eteC-4a22A:
undetectable		 3eteB-4a22A:
22.01
3eteC-4a22A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		4 / 8 ILE A  26
ILE A  50
VAL A 328
ILE A  38
 None
 0.87A 3p4wC-4a22A:
undetectable		 3p4wC-4a22A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		5 / 12 SER A  31
VAL A  34
THR A  94
PHE A 125
PHE A  52
 None
None
NA  A1347 (-3.6A)
None
None
 1.32A 4c49B-4a22A:
undetectable		 4c49B-4a22A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		5 / 12 SER A  31
VAL A  34
THR A  94
PHE A 125
PHE A  52
 None
None
NA  A1347 (-3.6A)
None
None
 1.41A 4c49C-4a22A:
undetectable		 4c49C-4a22A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		5 / 12 SER A  31
VAL A  34
THR A  94
PHE A 125
PHE A  52
 None
None
NA  A1347 (-3.6A)
None
None
 1.44A 4c49D-4a22A:
undetectable		 4c49D-4a22A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		4 / 8 ALA A  84
ILE A  38
LYS A   2
ILE A  50
 None
 0.86A 4kttB-4a22A:
undetectable		 4kttB-4a22A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		4 / 8 ALA A  84
ILE A  38
LYS A   2
ILE A  50
 None
 0.86A 4kttD-4a22A:
undetectable		 4kttD-4a22A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 204
ILE A 137
THR A 182
GLY A 163
 None
 1.00A 4l39A-4a22A:
1.6		 4l39A-4a22A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 137
LEU A 141
LEU A 204
PHE A 247
 None
 0.91A 4qopC-4a22A:
undetectable		 4qopC-4a22A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 102
ILE A 143
ALA A 144
ALA A 151
 None
 0.70A 4zf8A-4a22A:
undetectable		 4zf8A-4a22A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		4 / 8 SER A  46
ALA A  44
PRO A  24
LEU A 335
 None
 1.15A 5dzkd-4a22A:
4.1
5dzkr-4a22A:
undetectable		 5dzkd-4a22A:
22.73
5dzkr-4a22A:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  37
ASP A  47
THR A 343
PHE A  41
THR A   5
 None
 1.29A 5hfjH-4a22A:
undetectable		 5hfjH-4a22A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  34
THR A  33
VAL A  73
ALA A  72
LEU A  75
 None
 1.08A 5kocA-4a22A:
undetectable		 5kocA-4a22A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 158
HIS A  96
HIS A 252
GLU A 161
 None
ZN  A1348 ( 3.4A)
ZN  A1348 (-3.2A)
None
 1.07A 6pahA-4a22A:
undetectable		 6pahA-4a22A:
21.96