SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 4a25 FERRITIN DPS FAMILY
PROTEIN
(Kineococcus
radiotolerans) 		5 / 10 GLU A 115
ALA A 119
LEU A 120
LEU A  63
GLU A 163
 None
 1.29A 1a29A-4a25A:
undetectable		 1a29A-4a25A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4a25 FERRITIN DPS FAMILY
PROTEIN
(Kineococcus
radiotolerans) 		5 / 12 HIS A 132
ILE A 128
LEU A  30
VAL A  77
ALA A  78
 None
 1.15A 1tlsA-4a25A:
undetectable		 1tlsA-4a25A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4a25 FERRITIN DPS FAMILY
PROTEIN
(Kineococcus
radiotolerans) 		5 / 12 ILE A 128
LEU A  30
GLY A  29
VAL A  77
ALA A  78
 None
 1.01A 1tlsA-4a25A:
undetectable		 1tlsA-4a25A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 4a25 FERRITIN DPS FAMILY
PROTEIN
(Kineococcus
radiotolerans) 		5 / 12 HIS A 132
ILE A 128
LEU A  30
VAL A  77
ALA A  78
 None
 1.15A 1tlsB-4a25A:
undetectable		 1tlsB-4a25A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4a25 FERRITIN DPS FAMILY
PROTEIN
(Kineococcus
radiotolerans) 		5 / 12 HIS A 132
ILE A 128
LEU A  30
VAL A  77
ALA A  78
 None
 1.16A 1tsnA-4a25A:
undetectable		 1tsnA-4a25A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 4a25 FERRITIN DPS FAMILY
PROTEIN
(Kineococcus
radiotolerans) 		5 / 12 HIS A 132
LEU A  30
GLY A  29
VAL A  77
ALA A  78
 None
 0.93A 2kceB-4a25A:
undetectable		 2kceB-4a25A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 4a25 FERRITIN DPS FAMILY
PROTEIN
(Kineococcus
radiotolerans) 		4 / 6 ASN A  27
SER A  23
ALA A  22
ASP A 139
 None
 1.18A 3aruA-4a25A:
undetectable		 3aruA-4a25A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4a25 FERRITIN DPS FAMILY
PROTEIN
(Kineococcus
radiotolerans) 		5 / 12 VAL A  33
ALA A  39
GLN A  43
LEU A 120
VAL A 131
 None
 0.98A 3fc6C-4a25A:
undetectable		 3fc6C-4a25A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4a25 FERRITIN DPS FAMILY
PROTEIN
(Kineococcus
radiotolerans) 		4 / 8 LEU A 145
VAL A  33
LEU A  37
ALA A  78
 None
 0.87A 3uniB-4a25A:
undetectable		 3uniB-4a25A:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4a25 FERRITIN DPS FAMILY
PROTEIN
(Kineococcus
radiotolerans) 		5 / 12 ILE A 128
LEU A  30
GLY A  29
VAL A  77
ALA A  78
 None
 1.03A 4foxD-4a25A:
undetectable		 4foxD-4a25A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4a25 FERRITIN DPS FAMILY
PROTEIN
(Kineococcus
radiotolerans) 		5 / 12 HIS A 132
ILE A 128
LEU A  30
VAL A  77
ALA A  78
 None
 1.11A 4fqsA-4a25A:
undetectable		 4fqsA-4a25A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4a25 FERRITIN DPS FAMILY
PROTEIN
(Kineococcus
radiotolerans) 		5 / 12 ILE A 128
LEU A  30
GLY A  29
VAL A  77
ALA A  78
 None
 1.09A 4fqsA-4a25A:
undetectable		 4fqsA-4a25A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4a25 FERRITIN DPS FAMILY
PROTEIN
(Kineococcus
radiotolerans) 		5 / 12 HIS A 132
ILE A 128
LEU A  30
VAL A  77
ALA A  78
 None
 1.12A 4fqsB-4a25A:
undetectable		 4fqsB-4a25A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4a25 FERRITIN DPS FAMILY
PROTEIN
(Kineococcus
radiotolerans) 		5 / 12 ILE A 128
LEU A  30
GLY A  29
VAL A  77
ALA A  78
 None
 1.10A 4fqsB-4a25A:
undetectable		 4fqsB-4a25A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 4a25 FERRITIN DPS FAMILY
PROTEIN
(Kineococcus
radiotolerans) 		3 / 3 HIS A  41
TRP A  49
SER A  74
 None
 1.08A 4lrhD-4a25A:
undetectable		 4lrhD-4a25A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4a25 FERRITIN DPS FAMILY
PROTEIN
(Kineococcus
radiotolerans) 		5 / 12 LEU A  40
LEU A  63
ALA A 116
VAL A 103
ALA A  47
 None
 1.19A 4x1kD-4a25A:
undetectable		 4x1kD-4a25A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4a25 FERRITIN DPS FAMILY
PROTEIN
(Kineococcus
radiotolerans) 		4 / 5 VAL A 114
ASN A  55
ASP A  58
LEU A  59
 None
MN  A1172 (-2.6A)
MN  A1172 (-2.8A)
None
 1.35A 5m0iB-4a25A:
3.9		 5m0iB-4a25A:
20.08