SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a26'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC
(Leishmania
major) 		5 / 10 GLU A  19
GLU A 285
ALA A 281
ALA A  13
GLY A   9
 None
 1.33A 1mjqG-4a26A:
undetectable
1mjqH-4a26A:
undetectable		 1mjqG-4a26A:
19.93
1mjqH-4a26A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC
(Leishmania
major) 		4 / 4 ALA A  59
VAL A  63
ALA A  60
HIS A  57
 None
 1.10A 1q23A-4a26A:
undetectable		 1q23A-4a26A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC
(Leishmania
major) 		4 / 4 ALA A  59
VAL A  63
ALA A  60
HIS A  57
 None
 1.07A 1q23F-4a26A:
undetectable		 1q23F-4a26A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC
(Leishmania
major) 		4 / 4 ALA A  59
VAL A  63
ALA A  60
HIS A  57
 None
 1.07A 1q23K-4a26A:
undetectable		 1q23K-4a26A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC
(Leishmania
major) 		3 / 3 LEU A 103
PRO A 104
LEU A 107
 None
 0.42A 2qd5B-4a26A:
3.0		 2qd5B-4a26A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC
(Leishmania
major) 		5 / 11 MET A 161
ILE A 211
LEU A 182
LEU A 154
ILE A 151
 None
 1.41A 3a50B-4a26A:
undetectable		 3a50B-4a26A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC
(Leishmania
major) 		3 / 3 LEU A 103
PRO A 104
LEU A 107
 None
 0.48A 3w1wB-4a26A:
3.5		 3w1wB-4a26A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC
(Leishmania
major) 		4 / 8 ASN A 110
ASP A 123
LEU A 125
ILE A 174
 None
 1.06A 4k0bA-4a26A:
undetectable		 4k0bA-4a26A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC
(Leishmania
major) 		4 / 8 ASN A 110
ASP A 123
LEU A 125
ILE A 174
 None
 1.05A 4l7iA-4a26A:
undetectable		 4l7iA-4a26A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC
(Leishmania
major) 		3 / 3 ARG A 111
LYS A 115
GLU A  82
 None
 0.83A 5d0yA-4a26A:
undetectable		 5d0yA-4a26A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC
(Leishmania
major) 		4 / 8 ALA A 124
PRO A 141
LEU A 133
LEU A 132
 None
 1.00A 5dzkd-4a26A:
undetectable
5dzkr-4a26A:
undetectable		 5dzkd-4a26A:
22.56
5dzkr-4a26A:
1.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC
(Leishmania
major) 		6 / 12 ASP A 123
THR A 146
SER A 172
ILE A 174
VAL A 175
THR A 279
 None
 0.68A 6debB-4a26A:
39.2		 6debB-4a26A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC
(Leishmania
major) 		5 / 12 GLN A 100
ASP A 123
THR A 146
VAL A 175
THR A 279
 None
 0.66A 6debB-4a26A:
39.2		 6debB-4a26A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC
(Leishmania
major) 		5 / 12 GLN A 100
LEU A 101
PRO A 102
ASP A 123
THR A 279
 None
 0.62A 6debB-4a26A:
39.2		 6debB-4a26A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC
(Leishmania
major) 		5 / 12 GLN A 100
PRO A 102
ASP A 123
THR A 146
THR A 279
 None
 0.63A 6debB-4a26A:
39.2		 6debB-4a26A:
12.94