SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		5 / 10 ALA A 128
SER A 154
PHE A 155
ALA A  77
ILE A  73
 None
 1.17A 1g5yC-4a27A:
undetectable		 1g5yC-4a27A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		4 / 6 PHE A 318
GLU A 174
LEU A 172
VAL A 197
 None
 0.94A 1hk1A-4a27A:
undetectable		 1hk1A-4a27A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		5 / 12 LEU A 251
TYR A 275
GLY A 194
GLY A 192
ALA A 196
 None
 1.27A 1httD-4a27A:
2.1		 1httD-4a27A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJY_H_BEZH306_0
(ANTIBODY 7A1 FAB')		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		4 / 4 ASN A 232
ALA A 213
ARG A 231
TYR A 235
 None
EDO  A1390 ( 3.9A)
None
None
 1.40A 2ajyH-4a27A:
undetectable		 2ajyH-4a27A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AK1_H_BEZH401_0
(ANTIBODY 7A1 FAB')		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		4 / 4 ASN A 232
ALA A 213
ARG A 231
TYR A 235
 None
EDO  A1390 ( 3.9A)
None
None
 1.43A 2ak1H-4a27A:
0.0		 2ak1H-4a27A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		5 / 12 ILE A 221
ALA A 196
GLY A 192
GLY A 190
PRO A 351
 None
None
None
EDO  A1390 (-3.4A)
None
 1.18A 2okcB-4a27A:
undetectable		 2okcB-4a27A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		5 / 12 GLY A 373
ASN A 374
PHE A 216
GLY A 376
ASP A 354
 None
EDO  A1390 (-3.8A)
None
None
None
 0.91A 2pkkA-4a27A:
undetectable		 2pkkA-4a27A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		5 / 12 GLY A 373
ASN A 374
PHE A 216
GLY A 376
ASP A 354
 None
EDO  A1390 (-3.8A)
None
None
None
 0.90A 2pkmA-4a27A:
2.4		 2pkmA-4a27A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		5 / 12 LEU A 321
PHE A 325
LEU A 320
LEU A 340
VAL A 336
 None
 1.14A 2po7B-4a27A:
3.6		 2po7B-4a27A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		5 / 12 LEU A 321
PHE A 325
LEU A 320
LEU A 340
VAL A 336
 None
 1.34A 2qd4A-4a27A:
2.9		 2qd4A-4a27A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		5 / 12 TYR A 169
LEU A 172
VAL A 197
ILE A 249
THR A 271
 None
None
None
None
EDO  A1387 (-3.9A)
 1.23A 3frqA-4a27A:
undetectable		 3frqA-4a27A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		5 / 10 GLY A 342
PHE A 161
GLU A 338
LEU A 343
ILE A 349
 None
 1.18A 3kvrA-4a27A:
undetectable		 3kvrA-4a27A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		5 / 10 GLY A 342
PHE A 161
GLU A 338
LEU A 343
ILE A 349
 None
 1.22A 3kvrB-4a27A:
undetectable		 3kvrB-4a27A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		5 / 12 GLY A 246
LYS A 267
VAL A 186
ASP A 248
LEU A 172
 None
 0.85A 3m6vA-4a27A:
5.4		 3m6vA-4a27A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		5 / 12 GLY A 246
LYS A 267
VAL A 186
ASP A 248
LEU A 172
 None
 0.77A 3m6vB-4a27A:
5.4		 3m6vB-4a27A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		3 / 3 LYS A 267
PRO A 268
LEU A 269
 None
 0.44A 3tpxE-4a27A:
undetectable		 3tpxE-4a27A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		5 / 11 VAL A 170
ALA A 168
SER A 319
PHE A 104
LEU A 324
 None
 1.02A 4eilE-4a27A:
2.6		 4eilE-4a27A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		5 / 12 GLY A 194
GLY A 191
GLY A 190
VAL A 186
VAL A 184
 None
EDO  A1390 (-3.8A)
EDO  A1390 (-3.4A)
None
None
 0.90A 4htfA-4a27A:
6.3		 4htfA-4a27A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		5 / 12 VAL A 170
SER A 319
PHE A 104
LEU A 324
VAL A 166
 None
 1.45A 4kyaB-4a27A:
undetectable		 4kyaB-4a27A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		5 / 12 VAL A 170
SER A 319
PHE A 104
LEU A 324
VAL A 166
 None
 1.43A 4kyaD-4a27A:
undetectable		 4kyaD-4a27A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		5 / 12 VAL A 170
SER A 319
PHE A 104
LEU A 324
VAL A 166
 None
 1.43A 4kyaF-4a27A:
undetectable		 4kyaF-4a27A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		5 / 12 VAL A 170
SER A 319
PHE A 104
LEU A 324
VAL A 166
 None
 1.42A 4kyaH-4a27A:
undetectable		 4kyaH-4a27A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE
(Homo
sapiens) 		3 / 3 LYS A 267
LYS A 240
SER A 243
 None
 1.41A 5odiA-4a27A:
3.2		 5odiA-4a27A:
20.19