SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a2b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 11 SER A 193
HIS A 131
LEU A 177
LEU A 130
ILE A  81
 None
 1.38A 1ee2A-4a2bA:
undetectable		 1ee2A-4a2bA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 11 SER A 193
HIS A 131
LEU A 177
LEU A 130
ILE A  81
 None
 1.39A 1ee2B-4a2bA:
undetectable		 1ee2B-4a2bA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 SER A 183
VAL A  60
THR A  11
ILE A  13
 None
 0.63A 1gtnC-4a2bA:
undetectable
1gtnD-4a2bA:
undetectable		 1gtnC-4a2bA:
12.47
1gtnD-4a2bA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 11 THR A 335
THR A 358
ALA A 339
GLY A 197
ALA A 382
 None
 1.23A 2f162-4a2bA:
undetectable		 2f162-4a2bA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 11 THR A 335
THR A 358
ALA A 339
GLY A 197
ALA A 382
 None
 1.23A 2f16N-4a2bA:
undetectable		 2f16N-4a2bA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 11 ALA A  36
LEU A  71
SER A  38
VAL A 181
ILE A  13
 None
 1.25A 4claA-4a2bA:
undetectable		 4claA-4a2bA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 LEU A  64
ILE A  81
THR A  11
GLY A  22
 None
 0.74A 4eq4A-4a2bA:
undetectable		 4eq4A-4a2bA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 LEU A  64
ILE A  81
THR A  11
GLY A  22
 None
 0.75A 4eq4B-4a2bA:
undetectable		 4eq4B-4a2bA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 LEU A  64
ILE A  81
THR A  11
GLY A  22
 None
 0.74A 4eqlA-4a2bA:
undetectable		 4eqlA-4a2bA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 LEU A  64
ILE A  81
THR A  11
GLY A  22
 None
 0.72A 4eqlB-4a2bA:
undetectable		 4eqlB-4a2bA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		4 / 6 LEU A  64
ILE A  81
THR A  11
GLY A  22
 None
 0.72A 4l39A-4a2bA:
undetectable		 4l39A-4a2bA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 LEU A  64
ILE A  81
THR A  11
GLY A  22
 None
 0.79A 4l39B-4a2bA:
undetectable		 4l39B-4a2bA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 THR A 335
THR A 358
ALA A 339
GLY A 197
ALA A 382
 None
 1.18A 4qvnV-4a2bA:
undetectable
4qvnb-4a2bA:
undetectable		 4qvnV-4a2bA:
21.93
4qvnb-4a2bA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 THR A 335
THR A 358
ALA A 339
GLY A 197
ALA A 382
 None
 1.17A 4qvnH-4a2bA:
undetectable
4qvnN-4a2bA:
undetectable		 4qvnH-4a2bA:
21.93
4qvnN-4a2bA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 7 SER A 309
ARG A 357
GLY A 331
THR A 200
GLU A 203
 None
 1.41A 5btaA-4a2bA:
undetectable
5btaC-4a2bA:
undetectable
5btaD-4a2bA:
undetectable		 5btaA-4a2bA:
22.45
5btaC-4a2bA:
22.45
5btaD-4a2bA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 6 SER A 309
ARG A 357
GLY A 331
THR A 200
GLU A 203
 None
 1.44A 5btaA-4a2bA:
undetectable
5btaB-4a2bA:
undetectable
5btaC-4a2bA:
undetectable		 5btaA-4a2bA:
22.45
5btaB-4a2bA:
21.13
5btaC-4a2bA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 6 SER A 309
ARG A 357
GLY A 330
THR A 200
GLU A 203
 None
 1.49A 5btcA-4a2bA:
undetectable
5btcC-4a2bA:
undetectable
5btcD-4a2bA:
undetectable		 5btcA-4a2bA:
22.45
5btcC-4a2bA:
22.45
5btcD-4a2bA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 6 SER A 309
ARG A 357
GLY A 331
THR A 200
GLU A 203
 None
 1.36A 5btcA-4a2bA:
undetectable
5btcC-4a2bA:
undetectable
5btcD-4a2bA:
undetectable		 5btcA-4a2bA:
22.45
5btcC-4a2bA:
22.45
5btcD-4a2bA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 6 SER A 309
ARG A 357
GLY A 330
THR A 200
GLU A 203
 None
 1.46A 5btcA-4a2bA:
undetectable
5btcB-4a2bA:
undetectable
5btcC-4a2bA:
undetectable		 5btcA-4a2bA:
22.45
5btcB-4a2bA:
21.13
5btcC-4a2bA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 6 SER A 309
ARG A 357
GLY A 331
THR A 200
GLU A 203
 None
 1.38A 5btcA-4a2bA:
undetectable
5btcB-4a2bA:
undetectable
5btcC-4a2bA:
undetectable		 5btcA-4a2bA:
22.45
5btcB-4a2bA:
21.13
5btcC-4a2bA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 7 SER A 309
ARG A 357
GLY A 330
THR A 200
GLU A 203
 None
 1.46A 5btfA-4a2bA:
undetectable
5btfB-4a2bA:
undetectable
5btfC-4a2bA:
undetectable		 5btfA-4a2bA:
22.45
5btfB-4a2bA:
21.13
5btfC-4a2bA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 7 SER A 309
ARG A 357
GLY A 331
THR A 200
GLU A 203
 None
 1.43A 5btfA-4a2bA:
undetectable
5btfB-4a2bA:
undetectable
5btfC-4a2bA:
undetectable		 5btfA-4a2bA:
22.45
5btfB-4a2bA:
21.13
5btfC-4a2bA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 7 SER A 309
ARG A 357
GLY A 331
THR A 200
GLU A 203
 None
 1.44A 5btfA-4a2bA:
undetectable
5btfC-4a2bA:
undetectable
5btfD-4a2bA:
undetectable		 5btfA-4a2bA:
22.45
5btfC-4a2bA:
22.45
5btfD-4a2bA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 10 LEU A  63
PHE A  79
PHE A   9
LEU A  35
ALA A  36
 None
 1.28A 5y7pD-4a2bA:
undetectable		 5y7pD-4a2bA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		4 / 5 TYR A  19
LYS A  21
GLY A 264
ILE A 261
 AGS  A1393 (-4.8A)
AGS  A1393 (-2.3A)
None
AGS  A1393 ( 4.3A)
 1.31A 6debB-4a2bA:
undetectable		 6debB-4a2bA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 10 THR A 335
GLY A 337
LEU A 213
PHE A 217
VAL A 241
 None
AGS  A1393 (-3.4A)
None
AGS  A1393 ( 4.3A)
None
 1.41A 6gnfC-4a2bA:
undetectable		 6gnfC-4a2bA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 10 THR A 335
GLY A 338
LEU A 213
PHE A 217
VAL A 241
 None
AGS  A1393 ( 4.5A)
None
AGS  A1393 ( 4.3A)
None
 1.25A 6gnfC-4a2bA:
undetectable		 6gnfC-4a2bA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 10 THR A 335
GLY A 338
LEU A 213
SER A 189
VAL A 241
 None
AGS  A1393 ( 4.5A)
None
None
None
 1.47A 6gnfC-4a2bA:
undetectable		 6gnfC-4a2bA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 THR A 335
THR A 358
ALA A 339
GLY A 197
ALA A 382
 None
 1.16A 6hwdV-4a2bA:
undetectable
6hwdb-4a2bA:
undetectable		 6hwdV-4a2bA:
11.47
6hwdb-4a2bA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 THR A 335
THR A 358
ALA A 339
GLY A 197
ALA A 382
 None
 1.17A 6hwdH-4a2bA:
undetectable
6hwdN-4a2bA:
undetectable		 6hwdH-4a2bA:
11.47
6hwdN-4a2bA:
11.49