SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a2i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		5 / 12 LEU V 206
LEU V 235
ILE V 170
VAL V 272
VAL V 137
 None
 1.22A 1hrkA-4a2iV:
4.0		 1hrkA-4a2iV:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		5 / 12 LEU V 206
LEU V 235
ILE V 170
VAL V 272
VAL V 137
 None
 1.25A 1hrkB-4a2iV:
3.4		 1hrkB-4a2iV:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		3 / 3 ILE V 219
ASP V 271
PHE V 266
 None
 0.59A 1uwjB-4a2iV:
undetectable		 1uwjB-4a2iV:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		5 / 12 LEU V 243
ASN V 233
LEU V 231
ALA V 234
LEU V 213
 None
 1.31A 1ya3A-4a2iV:
undetectable		 1ya3A-4a2iV:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		5 / 12 LEU V 243
LEU V 232
ASN V 233
LEU V 231
LEU V 213
 None
 1.11A 1zucB-4a2iV:
undetectable		 1zucB-4a2iV:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		5 / 12 LEU V 243
ASN V 233
LEU V 231
ALA V 234
LEU V 213
 None
 1.35A 2aa5B-4a2iV:
undetectable		 2aa5B-4a2iV:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		5 / 12 LEU V 232
ASN V 233
LEU V 231
ALA V 234
LEU V 213
 None
 1.18A 2aa6A-4a2iV:
undetectable		 2aa6A-4a2iV:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		5 / 12 LEU V 243
ASN V 233
LEU V 231
ALA V 234
LEU V 213
 None
 1.32A 2oaxB-4a2iV:
undetectable		 2oaxB-4a2iV:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		5 / 12 LEU V 243
ASN V 233
LEU V 231
ALA V 234
LEU V 213
 None
 1.34A 2oaxD-4a2iV:
undetectable		 2oaxD-4a2iV:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		5 / 12 LEU V 243
ASN V 233
LEU V 231
ALA V 234
LEU V 213
 None
 1.33A 2oaxE-4a2iV:
undetectable		 2oaxE-4a2iV:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		5 / 12 LEU V 206
LEU V 235
ILE V 170
VAL V 272
VAL V 137
 None
 1.12A 2po5A-4a2iV:
3.4		 2po5A-4a2iV:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		5 / 12 LEU V 206
LEU V 235
ILE V 170
VAL V 272
VAL V 137
 None
 1.16A 2po7A-4a2iV:
4.3		 2po7A-4a2iV:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		4 / 7 VAL V 135
TYR V 152
CYH V 156
ILE V 219
 None
 1.23A 2xz5B-4a2iV:
undetectable
2xz5E-4a2iV:
undetectable		 2xz5B-4a2iV:
21.09
2xz5E-4a2iV:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		5 / 12 GLY V 282
ARG V 216
ILE V 165
GLY V 222
ALA V 221
 None
 0.89A 3sudC-4a2iV:
undetectable		 3sudC-4a2iV:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		5 / 12 LEU V 206
LEU V 235
ILE V 170
VAL V 272
VAL V 137
 None
 1.25A 3w1wA-4a2iV:
3.4		 3w1wA-4a2iV:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		4 / 6 THR V 332
ASN V 336
ASP V 150
ILE V 149
 None
 1.16A 3w9tB-4a2iV:
undetectable		 3w9tB-4a2iV:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		4 / 8 VAL V 135
TYR V 152
CYH V 156
ILE V 219
 None
 1.02A 4bqtC-4a2iV:
undetectable
4bqtD-4a2iV:
undetectable		 4bqtC-4a2iV:
20.75
4bqtD-4a2iV:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		4 / 8 LEU V 231
VAL V 137
VAL V 135
GLN V 133
 None
 0.87A 4em2A-4a2iV:
undetectable		 4em2A-4a2iV:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		4 / 8 ALA V 261
ASP V 132
ILE V 131
ILE V 134
 None
 0.94A 5t8sA-4a2iV:
undetectable		 5t8sA-4a2iV:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA
(Salmonella
enterica) 		4 / 7 VAL V  52
VAL V  87
ILE V  78
ILE V  74
 None
 0.78A 5ywmX-4a2iV:
undetectable		 5ywmX-4a2iV:
13.83