SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4a2n ISOPRENYLCYSTEINE
CARBOXYL
METHYLTRANSFERASE
(Methanosarcina
acetivorans) 		4 / 6 LEU B 107
GLU B  42
PRO B  39
ARG B 163
 None
None
None
PLM  B1194 ( 4.6A)
 1.25A 3ltwA-4a2nB:
undetectable		 3ltwA-4a2nB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4a2n ISOPRENYLCYSTEINE
CARBOXYL
METHYLTRANSFERASE
(Methanosarcina
acetivorans) 		4 / 7 GLU B  42
GLU B 167
TYR B 129
HIS B 131
 None
SAH  B1193 (-3.5A)
SAH  B1193 (-3.4A)
None
 1.05A 4a97D-4a2nB:
2.6		 4a97D-4a2nB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4a2n ISOPRENYLCYSTEINE
CARBOXYL
METHYLTRANSFERASE
(Methanosarcina
acetivorans) 		4 / 5 GLU B  42
GLU B 167
TYR B 129
HIS B 131
 None
SAH  B1193 (-3.5A)
SAH  B1193 (-3.4A)
None
 1.16A 4a97J-4a2nB:
undetectable		 4a97J-4a2nB:
19.43