SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a2p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		4 / 6 SER A 413
VAL A 414
GLY A 415
GLU A 427
 None
 1.00A 1fduD-4a2pA:
2.4		 1fduD-4a2pA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		5 / 9 PHE A 369
LEU A 299
ILE A 327
VAL A 337
ILE A 341
 None
 1.02A 1gebA-4a2pA:
undetectable		 1gebA-4a2pA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		5 / 9 PHE A 369
LEU A 389
ILE A 353
VAL A 337
ILE A 341
 None
 1.33A 1gebA-4a2pA:
undetectable		 1gebA-4a2pA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		4 / 7 LEU A 299
VAL A 349
ILE A 341
VAL A 337
 None
 0.82A 1p2yA-4a2pA:
undetectable		 1p2yA-4a2pA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		5 / 11 PHE A 369
LEU A 299
VAL A 349
ILE A 341
VAL A 337
 None
 1.17A 1phgA-4a2pA:
undetectable		 1phgA-4a2pA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		5 / 12 VAL A 297
ILE A 347
ILE A 341
ILE A 368
LEU A 366
 None
 0.93A 1qhsA-4a2pA:
undetectable		 1qhsA-4a2pA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		5 / 12 VAL A 297
ILE A 347
ILE A 341
ILE A 368
LEU A 366
 None
 0.92A 1qhyA-4a2pA:
3.1		 1qhyA-4a2pA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		5 / 9 LEU A 598
LEU A 601
LEU A 565
ILE A 561
ILE A 476
 None
 1.25A 2f7aB-4a2pA:
undetectable		 2f7aB-4a2pA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		3 / 3 SER A 413
THR A 443
PHE A 777
 None
 0.72A 2x91A-4a2pA:
3.1		 2x91A-4a2pA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		3 / 3 ASP A 504
PHE A 505
LEU A 553
 None
 0.51A 2zi9A-4a2pA:
3.0		 2zi9A-4a2pA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		4 / 8 LYS A 261
ARG A 292
GLN A 439
GLU A 774
 None
 1.40A 3dh0A-4a2pA:
3.0		 3dh0A-4a2pA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		4 / 5 LEU A 371
ILE A 346
ALA A 294
PHE A 285
 None
 1.05A 4dc3B-4a2pA:
undetectable		 4dc3B-4a2pA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		5 / 11 LEU A 633
GLU A 614
LEU A 615
ALA A 622
LEU A 619
 None
 0.95A 4wg0B-4a2pA:
undetectable
4wg0C-4a2pA:
undetectable
4wg0D-4a2pA:
undetectable		 4wg0B-4a2pA:
2.34
4wg0C-4a2pA:
2.34
4wg0D-4a2pA:
2.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		5 / 11 ALA A 622
LEU A 619
GLU A 614
LEU A 615
LEU A 633
 None
 0.94A 4wg0C-4a2pA:
undetectable
4wg0D-4a2pA:
undetectable
4wg0E-4a2pA:
undetectable		 4wg0C-4a2pA:
2.34
4wg0D-4a2pA:
2.34
4wg0E-4a2pA:
2.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		5 / 11 LEU A 633
GLU A 614
LEU A 615
ALA A 622
LEU A 619
 None
 0.95A 4wg0F-4a2pA:
undetectable
4wg0G-4a2pA:
undetectable
4wg0H-4a2pA:
undetectable		 4wg0F-4a2pA:
2.34
4wg0G-4a2pA:
2.34
4wg0H-4a2pA:
2.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		5 / 11 ALA A 622
LEU A 619
GLU A 614
LEU A 615
LEU A 633
 None
 0.93A 4wg0E-4a2pA:
undetectable
4wg0F-4a2pA:
undetectable
4wg0G-4a2pA:
undetectable		 4wg0E-4a2pA:
2.34
4wg0F-4a2pA:
2.34
4wg0G-4a2pA:
2.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		5 / 11 ALA A 622
LEU A 619
GLU A 614
LEU A 615
LEU A 633
 None
 0.94A 4wg0G-4a2pA:
undetectable
4wg0H-4a2pA:
undetectable
4wg0I-4a2pA:
undetectable		 4wg0G-4a2pA:
2.34
4wg0H-4a2pA:
2.34
4wg0I-4a2pA:
2.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		4 / 7 LYS A 738
ARG A 463
ASP A 461
TYR A 625
 None
 1.47A 5a06A-4a2pA:
undetectable		 5a06A-4a2pA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		4 / 7 LYS A 738
ARG A 463
ASP A 461
TYR A 625
 None
 1.50A 5a06C-4a2pA:
undetectable		 5a06C-4a2pA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		4 / 7 LYS A 738
ARG A 463
ASP A 461
TYR A 625
 None
 1.47A 5a06D-4a2pA:
undetectable		 5a06D-4a2pA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		4 / 7 LYS A 738
ARG A 463
ASP A 461
TYR A 625
 None
 1.48A 5a06E-4a2pA:
undetectable		 5a06E-4a2pA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		4 / 7 LYS A 738
ARG A 463
ASP A 461
TYR A 625
 None
 1.45A 5a06F-4a2pA:
2.1		 5a06F-4a2pA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		4 / 4 GLU A 597
PRO A 596
ILE A 599
LEU A 598
 None
 1.28A 5m45A-4a2pA:
undetectable		 5m45A-4a2pA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		4 / 4 GLU A 597
PRO A 596
ILE A 599
LEU A 598
 None
 1.26A 5m45G-4a2pA:
undetectable		 5m45G-4a2pA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		6 / 11 PHE A 358
LEU A 354
GLY A 361
PHE A 369
ILE A 368
ILE A 341
 None
 1.41A 6gp2A-4a2pA:
2.1		 6gp2A-4a2pA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		6 / 11 PHE A 358
LEU A 354
GLY A 361
PHE A 369
ILE A 368
ILE A 341
 None
 1.38A 6gp2B-4a2pA:
undetectable		 6gp2B-4a2pA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4a2p RETINOIC ACID
INDUCIBLE PROTEIN I
(Anas
platyrhynchos) 		5 / 9 MET A 481
SER A 478
ILE A 555
ALA A 564
LEU A 568
 None
 1.49A 6hqbB-4a2pA:
0.5		 6hqbB-4a2pA:
9.01