SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a34'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 4a34 RBSD/FUCU TRANSPORT
PROTEIN FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ILE A  85
PRO A  83
GLY A  87
MET A  92
TYR A  89
 None
 1.45A 1g60B-4a34A:
undetectable		 1g60B-4a34A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 4a34 RBSD/FUCU TRANSPORT
PROTEIN FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 THR A 102
ILE A  57
ASP A  64
THR A 104
 None
 0.94A 3q70A-4a34A:
undetectable		 3q70A-4a34A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4a34 RBSD/FUCU TRANSPORT
PROTEIN FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 ILE A 103
ILE A  93
THR A  98
THR A 102
 None
 0.87A 4em2A-4a34A:
undetectable		 4em2A-4a34A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4a34 RBSD/FUCU TRANSPORT
PROTEIN FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 TRP A  86
ALA A 131
ILE A  50
ASP A  30
ILE A 134
 None
None
None
FUL  A1142 (-2.8A)
None
 1.10A 4km0B-4a34A:
undetectable		 4km0B-4a34A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4a34 RBSD/FUCU TRANSPORT
PROTEIN FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 ILE A 134
TYR A 105
THR A 104
ILE A 103
 None
 0.83A 5mzrE-4a34A:
undetectable		 5mzrE-4a34A:
18.37