SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a35'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 4 ILE A 305
MET A 268
VAL A 225
GLY A 304
 None
 1.19A 1e06B-4a35A:
undetectable		 1e06B-4a35A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 8 LEU A 142
PHE A  92
GLY A  90
TRP A 127
 None
 1.07A 1fapB-4a35A:
undetectable		 1fapB-4a35A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 GLY A  28
GLY A  26
GLY A  25
ASP A  30
GLY A 362
 None
EDO  A1448 (-3.2A)
EDO  A1448 ( 4.9A)
None
None
 0.77A 1n2xB-4a35A:
undetectable		 1n2xB-4a35A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_1
(ORPHAN NUCLEAR
RECEPTOR PXR)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 VAL A 227
LEU A 298
CYH A 357
GLN A 330
ILE A 294
 None
 1.42A 1skxA-4a35A:
undetectable		 1skxA-4a35A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 7 TYR A  96
ASP A 155
TYR A 158
HIS A 116
 None
EDO  A1452 ( 4.9A)
None
None
 1.48A 2bytA-4a35A:
2.8		 2bytA-4a35A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 7 TYR A  96
ASP A 155
TYR A 158
HIS A 116
 None
EDO  A1452 ( 4.9A)
None
None
 1.49A 2bytD-4a35A:
undetectable		 2bytD-4a35A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 5 SER A 379
HIS A 371
ASP A 128
ASP A 144
 None
 1.15A 2oxtB-4a35A:
undetectable		 2oxtB-4a35A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 ALA A 121
GLY A  57
ASP A  17
VAL A  18
GLY A 364
 None
 0.88A 2qe6A-4a35A:
undetectable		 2qe6A-4a35A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 ALA A 121
GLY A  57
ASP A  17
VAL A  18
ARG A  19
 None
None
None
None
EDO  A1447 (-4.0A)
 0.96A 2qe6B-4a35A:
undetectable		 2qe6B-4a35A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 123
LEU A 129
GLN A 133
PHE A  95
CYH A 153
 None
 1.06A 2w8yA-4a35A:
undetectable		 2w8yA-4a35A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		5 / 8 VAL A  43
VAL A  44
GLY A  55
LYS A  54
ARG A  16
 None
 1.40A 3bjwA-4a35A:
undetectable		 3bjwA-4a35A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 TYR A 418
ALA A 360
GLY A 362
VAL A 363
GLY A 364
 None
 1.18A 3f8wA-4a35A:
undetectable		 3f8wA-4a35A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 TYR A 418
ALA A 360
GLY A 362
VAL A 363
GLY A 364
 None
 1.18A 3f8wC-4a35A:
undetectable		 3f8wC-4a35A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 4 GLY A 308
GLU A 281
ASP A 286
ASP A 332
 None
 0.98A 3mb5A-4a35A:
undetectable		 3mb5A-4a35A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		3 / 3 ASP A  17
GLY A  63
TYR A 432
 None
EDO  A1447 ( 4.1A)
EDO  A1447 (-4.2A)
 0.77A 3w9tC-4a35A:
undetectable		 3w9tC-4a35A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		3 / 3 ASP A  17
GLY A  65
TYR A 432
 None
None
EDO  A1447 (-4.2A)
 0.46A 3w9tC-4a35A:
undetectable		 3w9tC-4a35A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		3 / 3 ASP A  17
GLY A  63
TYR A 432
 None
EDO  A1447 ( 4.1A)
EDO  A1447 (-4.2A)
 0.77A 3w9tG-4a35A:
undetectable		 3w9tG-4a35A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		3 / 3 ASP A  17
GLY A  65
TYR A 432
 None
None
EDO  A1447 (-4.2A)
 0.46A 3w9tG-4a35A:
undetectable		 3w9tG-4a35A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		3 / 4 SER A 338
GLY A  55
GLU A 424
 None
 0.57A 4juoA-4a35A:
undetectable
4juoC-4a35A:
undetectable		 4juoA-4a35A:
21.48
4juoC-4a35A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		3 / 3 ARG A  19
ASP A  35
ASP A  30
 EDO  A1447 (-4.0A)
None
None
 0.67A 4kicB-4a35A:
2.3		 4kicB-4a35A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 6 SER A  14
GLU A  46
VAL A 427
ARG A  16
 None
 1.26A 4lnxA-4a35A:
undetectable		 4lnxA-4a35A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 7 ILE A 316
GLN A 319
ILE A 159
ASP A 161
 None
 1.02A 4w5oA-4a35A:
undetectable		 4w5oA-4a35A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 6 ILE A 316
GLN A 319
ILE A 159
ASP A 161
 None
 1.01A 4w5qA-4a35A:
undetectable		 4w5qA-4a35A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 6 ILE A 316
GLN A 319
ILE A 159
ASP A 161
 None
 1.16A 4w5tA-4a35A:
undetectable		 4w5tA-4a35A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 6 ILE A 316
GLN A 319
ILE A 159
ASP A 161
 None
 0.99A 4z4cA-4a35A:
undetectable		 4z4cA-4a35A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 6 ILE A 316
GLN A 319
ILE A 159
ASP A 161
 None
 0.99A 4z4dA-4a35A:
undetectable		 4z4dA-4a35A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 7 ILE A 316
GLN A 319
ILE A 159
ASP A 161
 None
 1.03A 4z4eA-4a35A:
undetectable		 4z4eA-4a35A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 7 ILE A 316
GLN A 319
ILE A 159
ASP A 161
 None
 0.99A 4z4gA-4a35A:
2.1		 4z4gA-4a35A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A  76
ALA A  77
VAL A  80
ILE A  58
ALA A 120
 None
 1.14A 5n5dB-4a35A:
3.4		 5n5dB-4a35A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 8 ASP A  37
THR A  22
HIS A 396
LEU A 441
 EDO  A1449 (-2.9A)
None
None
EDO  A1449 ( 4.7A)
 1.18A 5w97A-4a35A:
undetectable
5w97C-4a35A:
undetectable
5w97c-4a35A:
undetectable		 5w97A-4a35A:
19.28
5w97C-4a35A:
19.24
5w97c-4a35A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 7 LEU A 441
ASP A  37
THR A  22
HIS A 396
 EDO  A1449 ( 4.7A)
EDO  A1449 (-2.9A)
None
None
 1.16A 5w97C-4a35A:
undetectable
5w97a-4a35A:
undetectable
5w97c-4a35A:
undetectable		 5w97C-4a35A:
19.24
5w97a-4a35A:
19.28
5w97c-4a35A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 8 ASP A  37
THR A  22
HIS A 396
LEU A 441
 EDO  A1449 (-2.9A)
None
None
EDO  A1449 ( 4.7A)
 1.18A 5x19A-4a35A:
undetectable
5x19C-4a35A:
undetectable
5x19P-4a35A:
undetectable		 5x19A-4a35A:
19.28
5x19C-4a35A:
19.24
5x19P-4a35A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 7 ASP A  37
THR A  22
HIS A 396
LEU A 441
 EDO  A1449 (-2.9A)
None
None
EDO  A1449 ( 4.7A)
 1.20A 5x1fA-4a35A:
undetectable
5x1fC-4a35A:
undetectable
5x1fP-4a35A:
undetectable		 5x1fA-4a35A:
19.28
5x1fC-4a35A:
19.24
5x1fP-4a35A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 6 ILE A 316
GLN A 319
ILE A 159
ASP A 161
 None
 1.09A 6cbdA-4a35A:
undetectable		 6cbdA-4a35A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens) 		4 / 6 LEU A 326
TYR A 194
ASP A 254
GLU A 280
 None
None
MG  A1445 (-2.6A)
MG  A1445 (-3.0A)
 1.48A 6djzC-4a35A:
undetectable		 6djzC-4a35A:
18.90