SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a39'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		5 / 10 GLU A 174
HIS A 171
ALA A 212
PHE A 213
GLY A 215
 None
 1.44A 1cmcA-4a39A:
undetectable
1cmcB-4a39A:
undetectable		 1cmcA-4a39A:
13.59
1cmcB-4a39A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		4 / 7 HIS A  40
GLY A  10
ALA A   5
GLU A  44
 None
 0.75A 1dmaA-4a39A:
undetectable		 1dmaA-4a39A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 196
MET A 192
LEU A 364
VAL A 150
ILE A 181
 None
 1.29A 1ee2A-4a39A:
undetectable		 1ee2A-4a39A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 230
THR A 326
TYR A 327
 None
 1.27A 2a3aA-4a39A:
undetectable		 2a3aA-4a39A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 230
THR A 326
TYR A 327
 None
 1.21A 2a3aB-4a39A:
undetectable		 2a3aB-4a39A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 230
THR A 326
TYR A 327
 None
 1.28A 2a3bA-4a39A:
undetectable		 2a3bA-4a39A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		4 / 7 TYR A  64
GLU A 170
HIS A 260
GLY A 261
 None
ZN  A1376 ( 2.0A)
ZN  A1376 ( 3.2A)
GEM  A1377 (-4.8A)
 1.21A 2ha4B-4a39A:
3.4		 2ha4B-4a39A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 263
HIS A 167
GLU A 170
 None
ZN  A1376 ( 3.1A)
ZN  A1376 ( 2.0A)
 0.76A 2x45B-4a39A:
undetectable		 2x45B-4a39A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 335
HIS A 167
GLU A 170
 GEM  A1377 (-2.7A)
ZN  A1376 ( 3.1A)
ZN  A1376 ( 2.0A)
 0.82A 2x45B-4a39A:
undetectable		 2x45B-4a39A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 263
HIS A 167
GLU A 170
 None
ZN  A1376 ( 3.1A)
ZN  A1376 ( 2.0A)
 0.77A 2x45C-4a39A:
undetectable		 2x45C-4a39A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 335
HIS A 167
GLU A 170
 GEM  A1377 (-2.7A)
ZN  A1376 ( 3.1A)
ZN  A1376 ( 2.0A)
 0.84A 2x45C-4a39A:
undetectable		 2x45C-4a39A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 334
ALA A 164
LEU A 180
GLN A 361
LEU A 367
 None
 1.02A 3ix9A-4a39A:
undetectable		 3ix9A-4a39A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 364
ARG A 186
ILE A 181
LEU A 184
LEU A 201
 None
 1.09A 3k2hA-4a39A:
undetectable		 3k2hA-4a39A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A   8
SER A   9
GLU A 174
HIS A 171
 None
 1.26A 4aq7A-4a39A:
undetectable		 4aq7A-4a39A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 117
TRP A  82
GLY A  79
 None
 0.91A 4e7cA-4a39A:
undetectable		 4e7cA-4a39A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  94
LEU A  98
PHE A 107
PRO A  86
GLN A  72
 None
 1.42A 4hwkD-4a39A:
undetectable		 4hwkD-4a39A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 147
LEU A 201
GLN A 166
GLU A 174
 None
 1.22A 4i41A-4a39A:
undetectable		 4i41A-4a39A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  94
LEU A  98
PHE A 107
PRO A  86
GLN A  72
 None
 1.47A 4j7xJ-4a39A:
undetectable		 4j7xJ-4a39A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 360
VAL A 363
ILE A 259
LEU A 203
LEU A 255
 None
 1.01A 4pd4C-4a39A:
undetectable		 4pd4C-4a39A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 107
ALA A  17
MET A   1
MET A  46
 None
 0.91A 4rjdB-4a39A:
undetectable		 4rjdB-4a39A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		5 / 9 VAL A 105
ILE A  23
LEU A  56
PRO A 100
MET A   1
 None
 1.35A 5og9A-4a39A:
undetectable		 5og9A-4a39A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		4 / 5 HIS A 118
ASP A 210
GLY A 211
ASN A 206
 None
 1.36A 5x7pB-4a39A:
undetectable		 5x7pB-4a39A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		4 / 5 PRO A 100
VAL A 105
GLY A 348
VAL A  85
 None
 1.09A 6ak3B-4a39A:
undetectable		 6ak3B-4a39A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 151
LYS A 159
TYR A 202
 None
 1.19A 6gnaA-4a39A:
1.7		 6gnaA-4a39A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4a39 METALLO-CARBOXYPEPTI
DASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 151
LYS A 159
TYR A 202
 None
 1.19A 6gnbA-4a39A:
1.7		 6gnbA-4a39A:
21.39