SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a3p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1C4D_B_DVAB8_0 (GRAMICIDIN A)	4a3p	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15 (Homo sapiens)	3 / 3	TRP A 41 VAL A 60 TRP A 37	None	1.26A	1c4dA-4a3pA: undetectable 1c4dB-4a3pA: undetectable	1c4dA-4a3pA: 6.32 1c4dB-4a3pA: 6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QX3_A_EVPA1_1 (DNA TOPOISOMERASE 2-BETA)	4a3p	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15 (Homo sapiens)	4 / 5	GLY A 27 ASP A 28 ARG A 25 GLN A 120	None	1.26A	3qx3A-4a3pA: undetectable	3qx3A-4a3pA: 13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QX3_D_EVPD1_1 (DNA TOPOISOMERASE 2-BETA)	4a3p	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15 (Homo sapiens)	4 / 5	GLY A 27 ASP A 28 ARG A 25 GLN A 120	None	1.20A	3qx3B-4a3pA: undetectable	3qx3B-4a3pA: 13.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4A3P_A_ACTA1223_0 (UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15)	4a3p	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15 (Homo sapiens)	5 / 5	ASP A 15 THR A 18 LEU A 19 GLU A 95 LYS A 99	ACT A1223 (-3.2A) ACT A1223 ( 3.9A) ACT A1223 (-4.5A) ACT A1223 (-2.8A) ACT A1223 (-2.8A)	0.00A	4a3pA-4a3pA: 32.4	4a3pA-4a3pA: 100.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1C4D_B_DVAB8_0","GRAMICIDIN A","4a3p","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15","Homo sapiens",3,"TRP A  41;VAL A  60;TRP A  37","None","1.26A","1c4dA-4a3pA:undetectable;1c4dB-4a3pA:undetectable","1c4dA-4a3pA:6.32;1c4dB-4a3pA:6.32"],["3QX3_A_EVPA1_1","DNA TOPOISOMERASE 2-BETA","4a3p","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15","Homo sapiens",4,"GLY A  27;ASP A  28;ARG A  25;GLN A 120","None","1.26A","3qx3A-4a3pA:undetectable","3qx3A-4a3pA:13.82"],["3QX3_D_EVPD1_1","DNA TOPOISOMERASE 2-BETA","4a3p","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15","Homo sapiens",4,"GLY A  27;ASP A  28;ARG A  25;GLN A 120","None","1.20A","3qx3B-4a3pA:undetectable","3qx3B-4a3pA:13.82"],["4A3P_A_ACTA1223_0","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15","4a3p","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15","Homo sapiens",5,"ASP A  15;THR A  18;LEU A  19;GLU A  95;LYS A  99","ACT A1223 (-3.2A);ACT A1223 ( 3.9A);ACT A1223 (-4.5A);ACT A1223 (-2.8A);ACT A1223 (-2.8A)","0.00A","4a3pA-4a3pA:32.4","4a3pA-4a3pA:100.00"]]