SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a3q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4a3q ALANINE RACEMASE 1
(Staphylococcus
aureus) 		4 / 7 VAL A 150
ILE A 154
HIS A 200
LEU A  83
 None
 0.93A 1j96B-4a3qA:
2.7		 1j96B-4a3qA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4a3q ALANINE RACEMASE 1
(Staphylococcus
aureus) 		3 / 3 LYS A 195
LYS A 187
VAL A 190
 None
 1.04A 3brfA-4a3qA:
undetectable		 3brfA-4a3qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4a3q ALANINE RACEMASE 1
(Staphylococcus
aureus) 		5 / 12 PHE A 166
ILE A 130
VAL A 165
LEU A 103
VAL A 150
 None
 1.19A 3fpjB-4a3qA:
undetectable		 3fpjB-4a3qA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 4a3q ALANINE RACEMASE 1
(Staphylococcus
aureus) 		5 / 11 GLU A 163
HIS A 129
VAL A 105
ALA A 114
LEU A 126
 None
 1.24A 3mdzA-4a3qA:
undetectable		 3mdzA-4a3qA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 4a3q ALANINE RACEMASE 1
(Staphylococcus
aureus) 		5 / 12 GLU A 152
VAL A 165
ILE A 130
TYR A 147
GLU A 192
 None
 1.49A 4a99A-4a3qA:
undetectable
4a99C-4a3qA:
undetectable		 4a99A-4a3qA:
24.16
4a99C-4a3qA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 4a3q ALANINE RACEMASE 1
(Staphylococcus
aureus) 		4 / 5 HIS A 369
LEU A 360
LEU A 331
ASP A 286
 None
 1.13A 4aqlA-4a3qA:
3.6		 4aqlA-4a3qA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 4a3q ALANINE RACEMASE 1
(Staphylococcus
aureus) 		5 / 12 LEU A 209
VAL A 237
ALA A 205
LEU A  28
LEU A 241
 None
None
None
None
SO4  A1383 (-4.9A)
 1.19A 4i1rA-4a3qA:
undetectable		 4i1rA-4a3qA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_C_QELC939_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4a3q ALANINE RACEMASE 1
(Staphylococcus
aureus) 		5 / 10 LEU A  83
ALA A 217
ILE A 218
PHE A  25
GLU A 163
 None
 1.48A 4pe5C-4a3qA:
undetectable
4pe5D-4a3qA:
undetectable		 4pe5C-4a3qA:
19.15
4pe5D-4a3qA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 4a3q ALANINE RACEMASE 1
(Staphylococcus
aureus) 		5 / 12 LEU A 128
LEU A  67
ALA A  70
ALA A  96
VAL A 101
 None
 0.99A 4rn6B-4a3qA:
undetectable		 4rn6B-4a3qA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4a3q ALANINE RACEMASE 1
(Staphylococcus
aureus) 		4 / 6 HIS A  29
ARG A 219
GLN A 202
HIS A 200
 SO4  A1387 (-4.4A)
PLP  A1039 (-3.7A)
None
None
 1.42A 5kkzA-4a3qA:
undetectable
5kkzG-4a3qA:
undetectable		 5kkzA-4a3qA:
21.91
5kkzG-4a3qA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4a3q ALANINE RACEMASE 1
(Staphylococcus
aureus) 		4 / 7 VAL A 251
VAL A 317
PRO A 320
ALA A 278
 None
 0.73A 5osrA-4a3qA:
undetectable		 5osrA-4a3qA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 4a3q ALANINE RACEMASE 1
(Staphylococcus
aureus) 		5 / 12 LEU A  54
ILE A  78
LEU A  15
VAL A  18
ALA A  19
 None
 0.97A 6ajiA-4a3qA:
undetectable		 6ajiA-4a3qA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4a3q ALANINE RACEMASE 1
(Staphylococcus
aureus) 		3 / 3 TYR A 198
HIS A 200
PHE A  61
 None
 1.06A 6esmA-4a3qA:
undetectable		 6esmA-4a3qA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 4a3q ALANINE RACEMASE 1
(Staphylococcus
aureus) 		4 / 6 LEU A 280
THR A 315
GLY A 283
ARG A   7
 None
 0.93A 6gtqB-4a3qA:
undetectable
6gtqD-4a3qA:
undetectable		 6gtqB-4a3qA:
17.11
6gtqD-4a3qA:
8.87