SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a3r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4a3r ENOLASE
(Bacillus
subtilis) 		4 / 5 HIS A 155
GLU A 164
ALA A 243
SER A 245
 None
 1.19A 1errA-4a3rA:
undetectable
1errB-4a3rA:
undetectable		 1errA-4a3rA:
22.44
1errB-4a3rA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 4a3r ENOLASE
(Bacillus
subtilis) 		5 / 12 THR A 372
ILE A 380
ILE A 365
ILE A 111
ALA A 108
 None
 1.24A 1jtxA-4a3rA:
undetectable		 1jtxA-4a3rA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4a3r ENOLASE
(Bacillus
subtilis) 		4 / 7 TYR A 403
ILE A 167
PRO A 169
ALA A 178
 None
 0.98A 1oniD-4a3rA:
undetectable
1oniE-4a3rA:
undetectable		 1oniD-4a3rA:
17.29
1oniE-4a3rA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 4a3r ENOLASE
(Bacillus
subtilis) 		3 / 3 ASP A 398
ARG A 396
ASP A  14
 None
 0.86A 1vptA-4a3rA:
undetectable		 1vptA-4a3rA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4a3r ENOLASE
(Bacillus
subtilis) 		4 / 5 PRO A 173
ILE A 422
GLY A 421
TYR A 419
 None
 1.18A 2jkjD-4a3rA:
undetectable		 2jkjD-4a3rA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4a3r ENOLASE
(Bacillus
subtilis) 		4 / 5 PRO A 173
ILE A 422
GLY A 421
TYR A 419
 None
 1.17A 2jkjF-4a3rA:
undetectable		 2jkjF-4a3rA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4a3r ENOLASE
(Bacillus
subtilis) 		4 / 8 LEU A 189
LEU A 219
VAL A 160
GLY A 152
 None
 0.96A 2po5A-4a3rA:
undetectable		 2po5A-4a3rA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 4a3r ENOLASE
(Bacillus
subtilis) 		4 / 7 LEU A 258
TRP A 273
GLY A 289
PHE A 248
 None
 0.86A 2wq5A-4a3rA:
undetectable		 2wq5A-4a3rA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4a3r ENOLASE
(Bacillus
subtilis) 		3 / 3 TYR A   8
GLU A  11
ASP A  55
 None
 0.74A 3bxoA-4a3rA:
undetectable		 3bxoA-4a3rA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4a3r ENOLASE
(Bacillus
subtilis) 		3 / 3 TYR A   8
GLU A  11
ASP A  55
 None
 0.78A 3bxoB-4a3rA:
undetectable		 3bxoB-4a3rA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 4a3r ENOLASE
(Bacillus
subtilis) 		5 / 12 PHE A 165
GLY A 392
ILE A 162
LEU A 219
TYR A 403
 None
 1.24A 3eeoA-4a3rA:
undetectable		 3eeoA-4a3rA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4a3r ENOLASE
(Bacillus
subtilis) 		4 / 7 VAL A  23
ILE A  90
THR A 347
GLY A 113
 None
 0.94A 3gssA-4a3rA:
undetectable		 3gssA-4a3rA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4a3r ENOLASE
(Bacillus
subtilis) 		4 / 7 VAL A  23
ILE A  90
THR A 347
GLY A 113
 None
 0.98A 3gssB-4a3rA:
undetectable		 3gssB-4a3rA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4a3r ENOLASE
(Bacillus
subtilis) 		4 / 4 LYS A 357
GLN A 388
ILE A 377
LEU A 134
 None
 1.47A 3qt0A-4a3rA:
undetectable		 3qt0A-4a3rA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 4a3r ENOLASE
(Bacillus
subtilis) 		4 / 4 ASP A 291
ASP A 294
GLY A 289
THR A 302
 None
 1.20A 3tl9B-4a3rA:
undetectable		 3tl9B-4a3rA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4a3r ENOLASE
(Bacillus
subtilis) 		3 / 3 LYS A 280
GLU A 216
TRP A 273
 None
 0.88A 3v4tH-4a3rA:
undetectable		 3v4tH-4a3rA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 4a3r ENOLASE
(Bacillus
subtilis) 		5 / 9 GLU A 205
GLY A 206
PRO A 394
TYR A 403
GLY A 182
 None
 1.47A 4fimA-4a3rA:
undetectable		 4fimA-4a3rA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4a3r ENOLASE
(Bacillus
subtilis) 		5 / 12 PHE A 425
ALA A 240
VAL A 312
LEU A 337
GLN A 310
 None
 1.12A 4j6dB-4a3rA:
undetectable		 4j6dB-4a3rA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4a3r ENOLASE
(Bacillus
subtilis) 		5 / 12 PHE A 425
ALA A 240
VAL A 312
LEU A 337
GLN A 310
 None
 1.08A 4jbtA-4a3rA:
undetectable		 4jbtA-4a3rA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 4a3r ENOLASE
(Bacillus
subtilis) 		5 / 12 GLY A 392
ASN A 148
MET A 147
ILE A 389
LEU A 337
 None
 1.06A 4kosA-4a3rA:
undetectable		 4kosA-4a3rA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		 4a3r ENOLASE
(Bacillus
subtilis) 		5 / 12 GLY A 392
ASN A 148
MET A 147
SER A 366
LEU A 337
 None
 1.16A 4kowA-4a3rA:
undetectable		 4kowA-4a3rA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOY_A_CSCA214_1
(UNCHARACTERIZED
PROTEIN)		 4a3r ENOLASE
(Bacillus
subtilis) 		5 / 11 GLY A 392
ASN A 148
MET A 147
ILE A 389
LEU A 337
 None
 1.02A 4koyA-4a3rA:
undetectable		 4koyA-4a3rA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4a3r ENOLASE
(Bacillus
subtilis) 		4 / 7 LEU A 277
VAL A 278
PRO A 282
GLU A 216
 None
 1.11A 4lb2A-4a3rA:
undetectable		 4lb2A-4a3rA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4a3r ENOLASE
(Bacillus
subtilis) 		5 / 12 ALA A 156
ALA A 218
LEU A 212
LEU A 189
ILE A 222
 None
 1.16A 4lnwA-4a3rA:
undetectable		 4lnwA-4a3rA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4a3r ENOLASE
(Bacillus
subtilis) 		5 / 12 ALA A 156
ALA A 218
LEU A 212
LEU A 189
ILE A 222
 None
 1.16A 4lnxA-4a3rA:
undetectable		 4lnxA-4a3rA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4a3r ENOLASE
(Bacillus
subtilis) 		5 / 12 VAL A  21
ILE A 111
LEU A  79
VAL A  25
ALA A 117
 None
 1.11A 4m11C-4a3rA:
undetectable		 4m11C-4a3rA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4a3r ENOLASE
(Bacillus
subtilis) 		5 / 12 VAL A  21
ILE A 111
LEU A  79
VAL A  25
ALA A 117
 None
 1.12A 4m11D-4a3rA:
undetectable		 4m11D-4a3rA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4a3r ENOLASE
(Bacillus
subtilis) 		6 / 12 GLY A 107
GLY A 104
LEU A 112
ASN A 109
ILE A 343
THR A 349
 None
 1.45A 4n49A-4a3rA:
undetectable		 4n49A-4a3rA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4a3r ENOLASE
(Bacillus
subtilis) 		4 / 6 LEU A 346
ASP A 374
VAL A 382
ALA A 381
 None
 1.14A 4nkvC-4a3rA:
undetectable		 4nkvC-4a3rA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 4a3r ENOLASE
(Bacillus
subtilis) 		5 / 12 LEU A 112
THR A 376
ILE A 380
GLN A  87
THR A 349
 None
 1.17A 4o5fA-4a3rA:
undetectable
4o5fB-4a3rA:
undetectable		 4o5fA-4a3rA:
20.79
4o5fB-4a3rA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4a3r ENOLASE
(Bacillus
subtilis) 		6 / 12 THR A 141
ILE A 422
GLY A 421
PRO A 169
ALA A 178
ILE A 284
 None
 1.24A 4rvgA-4a3rA:
undetectable		 4rvgA-4a3rA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4a3r ENOLASE
(Bacillus
subtilis) 		5 / 12 ASP A 379
TYR A 131
THR A 416
ALA A 414
ALA A 417
 None
 1.08A 4u15A-4a3rA:
undetectable		 4u15A-4a3rA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 4a3r ENOLASE
(Bacillus
subtilis) 		5 / 12 LEU A 112
THR A 376
ILE A 380
GLN A  87
THR A 349
 None
 1.21A 5b8hA-4a3rA:
undetectable
5b8hB-4a3rA:
undetectable		 5b8hA-4a3rA:
22.69
5b8hB-4a3rA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4a3r ENOLASE
(Bacillus
subtilis) 		5 / 12 GLN A  87
THR A 349
LEU A 112
THR A 376
ILE A 380
 None
 1.22A 5b8hA-4a3rA:
undetectable
5b8hB-4a3rA:
undetectable		 5b8hA-4a3rA:
22.69
5b8hB-4a3rA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4a3r ENOLASE
(Bacillus
subtilis) 		5 / 9 ILE A 167
THR A 221
LEU A 189
ASN A 148
LEU A 212
 None
 1.38A 5fhzB-4a3rA:
undetectable		 5fhzB-4a3rA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 4a3r ENOLASE
(Bacillus
subtilis) 		4 / 8 HIS A 298
GLY A 333
LEU A 305
GLY A 306
 None
 0.78A 6mdqA-4a3rA:
2.1		 6mdqA-4a3rA:
11.97