SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		4 / 5 LEU A 263
LEU A 267
LEU A 274
GLY A 285
 None
 1.07A 1a4lC-4a3sA:
undetectable		 1a4lC-4a3sA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 10 ARG A 266
GLY A 138
ASP A 129
GLY A 101
ILE A 100
 None
 0.96A 1sh9B-4a3sA:
undetectable		 1sh9B-4a3sA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 11 ALA A 173
ASP A 175
SER A  13
ILE A 137
ILE A 130
 None
 1.13A 2blaA-4a3sA:
undetectable		 2blaA-4a3sA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		4 / 7 ARG A 204
SER A 314
GLN A 312
GLU A 316
 None
 1.29A 2c8aA-4a3sA:
undetectable		 2c8aA-4a3sA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 12 ILE A 218
ILE A 217
ALA A 186
ALA A 177
LEU A 247
 None
 0.94A 2h79A-4a3sA:
undetectable		 2h79A-4a3sA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 12 GLU A 235
ILE A 201
LEU A 190
GLY A 231
ILE A 234
 None
 1.30A 2ogyA-4a3sA:
undetectable		 2ogyA-4a3sA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 12 GLU A 235
ILE A 201
LEU A 190
GLY A 231
ILE A 234
 None
 1.33A 2ogyB-4a3sA:
undetectable		 2ogyB-4a3sA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		6 / 12 ILE A 130
ALA A 142
GLY A 138
GLY A 124
ASN A 144
ASN A 128
 None
 1.38A 2okcB-4a3sA:
undetectable		 2okcB-4a3sA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		4 / 4 ARG A  82
GLY A  85
GLU A  83
SER A   9
 None
 1.08A 2xctS-4a3sA:
undetectable
2xctU-4a3sA:
undetectable		 2xctS-4a3sA:
19.91
2xctU-4a3sA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 11 SER A 105
SER A   9
GLY A 108
ALA A 109
PHE A  76
 None
 1.28A 2xh9A-4a3sA:
undetectable		 2xh9A-4a3sA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 10 SER A 105
SER A   9
GLY A 108
ALA A 109
PHE A  76
 None
 1.28A 2xh9B-4a3sA:
undetectable		 2xh9B-4a3sA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 11 ALA A 264
LEU A 267
PRO A 123
GLY A 124
SER A  13
 None
 0.99A 3bpxA-4a3sA:
undetectable
3bpxB-4a3sA:
undetectable		 3bpxA-4a3sA:
20.00
3bpxB-4a3sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 12 ILE A 218
ILE A 217
ALA A 186
ALA A 177
LEU A 247
 None
 0.92A 3gwsX-4a3sA:
undetectable		 3gwsX-4a3sA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 12 GLY A 138
ASP A 127
GLY A 101
ILE A 100
ALA A 264
 None
 0.88A 3n3iA-4a3sA:
undetectable		 3n3iA-4a3sA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 9 ILE A 286
LEU A 267
ILE A 130
MET A  16
GLY A  15
 None
 1.32A 3sj4X-4a3sA:
undetectable		 3sj4X-4a3sA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 12 GLY A 254
ILE A 100
GLY A 138
ALA A  18
ALA A  19
 None
 1.08A 3sueA-4a3sA:
undetectable		 3sueA-4a3sA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		4 / 6 GLY A 185
GLY A 184
GLU A 187
ILE A 217
 None
 0.84A 4fglD-4a3sA:
4.5		 4fglD-4a3sA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 12 ILE A 137
ASP A 260
THR A 145
ILE A 126
GLU A 222
 None
 1.30A 4i41A-4a3sA:
undetectable		 4i41A-4a3sA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		4 / 6 ARG A 171
ASP A 134
GLY A 285
THR A 125
 None
 0.90A 4l1aB-4a3sA:
undetectable		 4l1aB-4a3sA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 12 VAL A  20
GLY A 124
SER A 265
GLY A 268
THR A   8
 None
 1.17A 4mm8A-4a3sA:
undetectable		 4mm8A-4a3sA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 12 VAL A 122
GLY A  15
GLY A  11
GLY A 138
ILE A 137
 None
 0.79A 4q5mA-4a3sA:
undetectable		 4q5mA-4a3sA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 9 ALA A  19
ALA A  18
GLY A 101
GLY A 124
ASP A 260
 None
 1.13A 4qwuK-4a3sA:
undetectable
4qwuL-4a3sA:
undetectable		 4qwuK-4a3sA:
21.41
4qwuL-4a3sA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 9 ALA A  19
ALA A  18
GLY A 101
GLY A 124
ASP A 260
 None
 1.16A 4qwuY-4a3sA:
undetectable
4qwuZ-4a3sA:
undetectable		 4qwuY-4a3sA:
21.41
4qwuZ-4a3sA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		4 / 4 GLY A 268
VAL A 284
PHE A 135
ILE A 286
 None
 0.97A 4xv2B-4a3sA:
undetectable		 4xv2B-4a3sA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		6 / 12 HIS A  62
ALA A 264
ALA A  18
VAL A  20
GLY A 138
THR A 141
 None
 1.24A 5igtA-4a3sA:
undetectable		 5igtA-4a3sA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 12 VAL A  23
ALA A  18
VAL A   6
GLY A   5
ILE A   4
 None
 0.80A 5j2tC-4a3sA:
undetectable		 5j2tC-4a3sA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		3 / 3 THR A 302
PRO A 131
ASP A 103
 None
 0.90A 5l8dB-4a3sA:
undetectable		 5l8dB-4a3sA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		3 / 3 THR A 302
PRO A 131
ASP A 103
 None
 0.90A 5mwuB-4a3sA:
undetectable		 5mwuB-4a3sA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 12 GLN A 312
LEU A 313
ASP A 175
ILE A 189
HIS A 304
 None
 1.25A 5uh6C-4a3sA:
undetectable		 5uh6C-4a3sA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 11 GLY A 268
ALA A  22
ALA A 264
ILE A 137
VAL A 122
 None
 1.03A 5yk2A-4a3sA:
undetectable		 5yk2A-4a3sA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 12 GLY A  15
PRO A 123
GLY A 124
ASN A  17
ASP A 260
 None
 1.36A 5yn6A-4a3sA:
undetectable		 5yn6A-4a3sA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		5 / 12 GLY A 268
ILE A 137
TYR A 106
CYH A 119
GLY A 101
 None
 1.01A 6bp4B-4a3sA:
undetectable		 6bp4B-4a3sA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		4 / 8 ASP A 295
ILE A 296
ARG A 282
TYR A 270
 None
 1.14A 6hisA-4a3sA:
undetectable
6hisB-4a3sA:
undetectable		 6hisA-4a3sA:
13.36
6hisB-4a3sA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		4 / 8 ASP A 295
ILE A 296
ARG A 282
TYR A 270
 None
 1.14A 6hisB-4a3sA:
undetectable
6hisC-4a3sA:
undetectable		 6hisB-4a3sA:
13.36
6hisC-4a3sA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		4 / 8 ASP A 295
ILE A 296
ARG A 282
TYR A 270
 None
 1.15A 6hisC-4a3sA:
undetectable
6hisD-4a3sA:
undetectable		 6hisC-4a3sA:
13.36
6hisD-4a3sA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		4 / 8 ASP A 295
ILE A 296
ARG A 282
TYR A 270
 None
 1.15A 6hisD-4a3sA:
undetectable
6hisE-4a3sA:
undetectable		 6hisD-4a3sA:
13.36
6hisE-4a3sA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4a3s 6-PHOSPHOFRUCTOKINAS
E
(Bacillus
subtilis) 		4 / 8 TYR A 270
ASP A 295
ILE A 296
ARG A 282
 None
 1.15A 6hisA-4a3sA:
undetectable
6hisE-4a3sA:
undetectable		 6hisA-4a3sA:
13.36
6hisE-4a3sA:
13.36